25 research outputs found
Chemical, morphological, structural, optical, and magnetic properties of Zn1−xNdxO nanoparticles
Frequency of rare and multi viral high-risk HPV types infection in cervical high grade squamous intraepithelial lesions in a non-native dominant middle eastern country: a polymerase chain reaction-based pilot study
Preparation of Co2TiO4/CoTiO3/Polyaniline ternary nano-hybrids for enhanced destruction of agriculture poison and organic dyes under visible-light irradiation
Statistical Modeling of Strain-Hardening Exponent and Grain Size of Nb-Microalloyed Steels Using a Two-Level Factorial Design of Experiment
Pathophysiology and epidemiology of peripartum cardiomyopathy
Cardiovascular diseases are a major cause of complications in pregnancy worldwide, and the number of patients who develop cardiac problems during pregnancy is increasing. Peripartum cardiomyopathy (PPCM) is a potentially life-threatening heart disease that emerges towards the end of pregnancy or in the first months postpartum, in previously healthy women. Symptoms and signs of PPCM are similar to those in patients with idiopathic dilated cardiomyopathy. The incidence varies geographically, most likely because of socioeconomic and genetic factors. The syndrome is associated with a high morbidity and mortality, and diagnosis is often delayed. Various mechanisms have been investigated, including the hypothesis that unbalanced peripartum or postpartum oxidative stress triggers the proteolytic cleavage of the nursing hormone prolactin into a potent antiangiogenic, proapoptotic, and proinflammatory 16 kDa fragment. This theory provides the basis for the discovery of disease-specific biomarkers and promising novel therapeutic targets. In this Review, we describe the latest understanding of the epidemiology, pathophysiology, and novel treatment strategies for patients with PPCM