80 research outputs found
Supersymmetric Chern-Simons Theories with Vector Matter
In this paper we discuss SU(N) Chern-Simons theories at level k with both
fermionic and bosonic vector matter. In particular we present an exact
calculation of the free energy of the N=2 supersymmetric model (with one chiral
field) for all values of the 't Hooft coupling in the large N limit. This is
done by using a generalization of the standard Hubbard-Stratanovich method
because the SUSY model contains higher order polynomial interactions.Comment: 46 pages, 24 figures, v2: comments and references added, v3: a
footnote in Section 3.5 adde
Phases of one dimensional large N gauge theory in a 1/D expansion
We consider large N Yang Mills theory with D adjoint scalar fields in d
dimensions for d=0 or 1. We show the existence of a non-trivial saddle point of
the functional integral at large D which is characterized by a mass gap for the
adjoint scalars. We integrate out the adjoint scalars in a 1/D expansion around
the saddle point. In case of one dimension which is regarded as a circle, this
procedure leads to an effective action for the Wilson line. We find an analogue
of the confinement/deconfinement transition which consists of a second order
phase transition from a uniform to a non-uniform eigenvalue distribution of the
Wilson line, closely followed by a Gross-Witten-Wadia transition where a gap
develops in the eigenvalue distribution. The phase transition can be regarded
as a continuation of a Gregory-Laflamme transition. Our methods involve large
values of the dimensionless 'tHooft coupling. The analysis in this paper is
quantitatively supported by earlier numerical work for D=9.Comment: 27 pages + 21 pages of Appendix; 8 figures, v2:some comments are
added in sec.4.3, minor corrections, one reference added, v3: minor
corrections, one reference added, version to be published in JHE
Thermodynamics of Large N Gauge Theories with Chemical Potentials in a 1/D Expansion
In order to understand thermodynamical properties of N D-branes with chemical
potentials associated with R-symmetry charges, we study a one dimensional large
N gauge theory (bosonic BFSS type model) as a first step. This model is
obtained through a dimensional reduction of a 1+D dimensional SU(N) Yang-Mills
theory and we use a 1/D expansion to investigate the phase structure. We find
three phases in the \mu-T plane. We also show that all the adjoint scalars
condense at large D and obtain a mass dynamically. This dynamical mass protects
our model from the usual perturbative instability of massless scalars in a
non-zero chemical potential. We find that the system is at least meta-stable
for arbitrary large values of the chemical potentials in D \to \infty limit. We
also explore the existence of similar condensation in higher dimensional gauge
theories in a high temperature limit. In 2 and 3 dimensions, the condensation
always happens as in one dimensional case. On the other hand, if the dimension
is higher than 4, there is a critical chemical potential and the condensation
happens only if the chemical potentials are below it.Comment: 37 pages, 4 figures; v2: minor corrections, references added; v3:
minor corrections, to appear in JHE
QCD with Chemical Potential in a Small Hyperspherical Box
To leading order in perturbation theory, we solve QCD, defined on a small
three sphere in the large N and Nf limit, at finite chemical potential and map
out the phase diagram in the (mu,T) plane. The action of QCD is complex in the
presence of a non-zero quark chemical potential which results in the sign
problem for lattice simulations. In the large N theory, which at low
temperatures becomes a conventional unitary matrix model with a complex action,
we find that the dominant contribution to the functional integral comes from
complexified gauge field configurations. For this reason the eigenvalues of the
Polyakov line lie off the unit circle on a contour in the complex plane. We
find at low temperatures that as mu passes one of the quark energy levels there
is a third-order Gross-Witten transition from a confined to a deconfined phase
and back again giving rise to a rich phase structure. We compare a range of
physical observables in the large N theory to those calculated numerically in
the theory with N=3. In the latter case there are no genuine phase transitions
in a finite volume but nevertheless the observables are remarkably similar to
the large N theory.Comment: 44 pages, 18 figures, jhep3 format. Small corrections and
clarifications added in v3. Conclusions cleaned up. Published versio
Weak coupling large-N transitions at finite baryon density
We study thermodynamics of free SU(N) gauge theory with a large number of
colours and flavours on a three-sphere, in the presence of a baryon number
chemical potential. Reducing the system to a holomorphic large-N matrix
integral, paying specific attention to theories with scalar flavours (squarks),
we identify novel third-order deconfining phase transitions as a function of
the chemical potential. These transitions in the complex large-N saddle point
configurations are interpreted as "melting" of baryons into (s)quarks. They are
triggered by the exponentially large (~ exp(N)) degeneracy of light baryon-like
states, which include ordinary baryons, adjoint-baryons and baryons made from
different spherical harmonics of flavour fields on the three-sphere. The phase
diagram of theories with scalar flavours terminates at a phase boundary where
baryon number diverges, representing the onset of Bose condensation of squarks.Comment: 38 pages, 7 figure
In Vivo Imaging of HIF-Active Tumors by an Oxygen-Dependent Degradation Protein Probe with an Interchangeable Labeling System
Hypoxia-inducible factor (HIF) functions as a master transcriptional regulator for adaptation to hypoxia by inducing adaptive changes in gene expression for regulation of proliferation, angiogenesis, apoptosis and energy metabolism. Cancers with high expression of the alpha subunit of HIF (HIFα) are often malignant and treatment-resistant. Therefore, the development of a molecular probe that can detect HIF activity has great potential value for monitoring tumor hypoxia. HIF prolyl hydroxylases (HPHDs) act as oxygen sensors that regulate the fate of HIFα protein through its oxygen-dependent degradation (ODD) domain. We constructed a recombinant protein PTD-ODD-HaloTag (POH) that is under the same ODD regulation as HIFα and contains protein transduction domain (PTD) and an interchangeable labeling system. Administration of near-infrared fluorescently labeled POH (POH-N) to mouse models of cancers allowed successful monitoring of HIF-active regions. Immunohistochemical analysis for intratumoral localization of POH probe revealed its specificity to HIF-active cells. Furthermore, lack of the PTD domain or a point mutation in the ODD domain abrogated the specificity of POH-N to HIF-active cells. Overall results indicate that POH is a practical probe specific to HIF-active cell in cancers and suggest its large potential for imaging and targeting of HIF-related diseases
What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?
The human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription protein Tat is an important factor in viral pathogenesis. In addition to its function as the key trans-activator of viral transcription, Tat is also secreted by the infected cell and taken up by neighboring cells where it has an effect both on infected and uninfected cells. In this review we will focus on the relationship between the structure of the Tat protein and its function as a secreted factor. To this end we will summarize some of the exogenous functions of Tat that have been implicated in HIV-1 pathogenesis and the impact of structural variations and viral subtype variants of Tat on those functions. Finally, since in some patients the presence of Tat-specific antibodies or CTL frequencies are associated with slow or non-progression to AIDS, we will also discuss the role of Tat as a potential vaccine candidate, the advances made in this field, and the importance of using a Tat protein capable of eliciting a protective or therapeutic immune response to viral challenge
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