KDM1A microenvironment, its oncogenic potential, and therapeutic significance

The lysine-specific histone demethylase 1A (KDM1A) was the first demethylase to challenge the concept of the irreversible nature of methylation marks. KDM1A, containing a flavin adenine dinucleotide (FAD)-dependent amine oxidase domain, demethylates histone 3 lysine 4 and histone 3 lysine 9 (H3K4me1/2 and H3K9me1/2). It has emerged as an epigenetic developmental regulator and was shown to be involved in carcinogenesis. The functional diversity of KDM1A originates from its complex structure and interactions with transcription factors, promoters, enhancers, oncoproteins, and tumor-associated genes (tumor suppressors and activators). In this review, we discuss the microenvironment of KDM1A in cancer progression that enables this protein to activate or repress target gene expression, thus making it an important epigenetic modifier that regulates the growth and differentiation potential of cells. A detailed analysis of the mechanisms underlying the interactions between KDM1A and the associated complexes will help to improve our understanding of epigenetic regulation, which may enable the discovery of more effective anticancer drugs

Research Trend of Aging Biochar for Agro-environmental Applications: a Bibliometric Data Analysis and Visualization of the Last Decade (2011-2023)

The copious amounts of data generated through publications play a pivotal role in advancing Science, Technology, and Policy. Additionally, they provide valuable and detailed information on research topics, emerging thematic trends, and critical issues that demand increased focus and attention. Over the last few decades, biochar has produced an extensive body of high-quality papers and played a crucial part in achieving the long-term Sustainable Development Goals of the 2030 agenda of the United Nations about "Climate Change," "Sustainable Agriculture," "Environmental Sustainability," "Zero Hunger," "Human Wellbeing," and "Circular Bioeconomy". However, most of the research is on biochar that has been modified or functionalized using various chemical reagents or catalysts and reported widely in peer-reviewed, high-quality journals. No prior work analyzed the bibliometric data on aging biochar with (a)biotic processes. This study presents an innovative data-driven bibliometric analysis technique and paradigm for extracting the essence of the available peer-reviewed literature data to offer new perspectives on the research opportunities and potential of aged biochar for agro-environmental applications. The bibliometric data analysis indicates that aging biochar research for agro-environmental applications received attention, advanced, and resulted in 165 high-quality publications in reputed journals between 2011 and 2023. However, it is evident that there is still a considerable need for further attention in this area. The identification of the research trends/frontiers shows that biochar production effectively employs various biomass resources, aging with different (a)biotic factors, characterization, effects on global climate change, long-term carbon sequestration in soil, soil nutrient dynamics, restoration of multi-polluted soils and sediments, and plant growth all require continuous attention both now and in the future

Biogas production from corn bioethanol whole stillage: Evaluation of two different inocula

According to EU Strategy for the Baltic Sea Region, Lithuania obligates to ensure sustainable growth, gain and maintain good condition of marine environment until 2020. In accordance with the sustainability approach, every potential cost and energy cutting as well as social sustainability measure for wastewater treatment should be explored. Nonetheless, Lithuania wastewater treatment plants (WWTP) in the sustainability context have never been evaluated before. A comprehensive set of 30 sustainable development indicators (SDI) (9 functional, 11 environmental, 5 economical and 6 socio-cultural) in connection with functional unit were applied to medium-sized Jurbarkas WWTP (with a capacity of 2,540 m³/d). Sustainability evaluation involved life cycle of WWTP maintenance phase as well as water inlet, outlet and manufacturing. Results revealed that in the general context of sustainability the stability of plant varied greatly. Nine SDI haven't reached the sustainability approach. Graphically systemized results in the four sustainability categories have shown that relatively highest environmental impact regarding the maximum covered plot is caused due to an economical unsustainability. Operational and maintenance costs per volume of wastewater treated were approximately 2.23 higher than the cost to consumers per one cubic meter of wastewater treated, therefore depreciation, repairs, material costs and wastewater treatment costs accounted to 87%. Methodology by using SDI for estimating sustainability of WWTP is adaptable to different capacity or technology of WWTP, comparable, simple to develop and improve