Letter from Daniel Muir [Sr.] to Daniel and Emma [Muir], 1882 Apr 1.

[4]Paul could not get of the way of righteousness by the law of Moses till Jesus Christ stoped him saying Paul why persecutest thou me then he Paul preached Christ crucified for the Sins of all men for he tasted death for all men. though mercy & free grace. not of works least any man should boast. So the apostles and those who believed through their ministry was commanded to go into all the world & preach Christ crucified for the Sins of all men for their original and actual Sins from their birth untill their death. No wonder at the true believers loving the [3?] one god for he tasted death for every man so that none need fear about having been missed or lost sight of by god. Gods word is all true it says cursed is the man that trusteth in man. Kings. or guids. but if man believes all gods word and obeysit by gods grace he shall never die. God says it. —I think god has sent me here being suitable for my old age & infirmities. my health is very good Please write me soon. give my love to the family. Yours in Christ Jesus. Daniel Muir.[1]Jefferson Arkansas 1882 April 1stDear Daniel and Emma my childrenMargret told me you wished me to write you a letter. when Jesus Christ our dear Saviour asked water to drink of the Samariten woman at the well. She said the jews have no dealings with the Samaritens. So why askest thou water of me. Jesus Said If thou hadest known who it is that asketh water of thee thou woudst have asked of him living water and thou would not thirst again. bu[illegible] would have been a well of water springing up in your heart to eternal life. For water is a figure of the Holy Ghost which is given to true believers yea a love to god which no water can quench throughout the countless ages of time and throughout eternity also. For Jesus Christ is made of God unto us wisdom. righteousness. Sanctification. and redemption that is the gift of god to us poor Sinners. it is all we need &[Page 2][2]We have all his Wisdom righteousness. Sanctification & redemption from Sin. Yea Jesus Christ is gifted to us with all his fullness of grace to Save us and preserve us eternally. [yea?] by that gift we are made heirs of god & joint heirs with Christ. yea we are made clean from Sin and Kept clean from it ever more and not by the work of the law. the law is fulfilled in us who walk not after the flesh but after the Spirit, for the law of the Spirit of life in Christ Jesus hath made me free from the law of Sin and death. First he Jesus. cleanses us from Sin and then keeps us from Sin ever more by his own power. while he was Suffering for our Sins on the cross he was brusing the Serpent the devils head yea it was then he conquered our bodies of the flesh Sin and the world. If it were possible our enemies would deceive the very elect.[3]If I did not believe gods Standard with all my heart I could not love god and the things of god with all my heart but thanks be to god I do believe every word in it. Seeing I can do nothing good of my Self. at any time when my mind is drawn away with the things of time the fire of love to god loses its heat. and the degree of joy is lessend then I soon perceive my loss & suddenly I cry out Lord come to thy place in my heart again fore I fear all things else but loss compared with thee then I get to my good treashure again and my Soul is Safe and [happy?] again. I cannot be happy with out constant fellowship with god I like Christian Christian fellowship but there is very little of it. But thank god he hath made the way clear for those who loves to walk wherein [Straite?] is the gate and [narrow?] the way that leadeth unto life & few there is that walk therein

Letter from Daniel Muir Sr. to Daniel H. Muir, 1865 ? 18

[1]Town of Buffalo 18th 1865. Dear Daniel I recieved yours of the 3d that we were thinking you were long of writing but we were glad to hear you were both well in body. I should like to give you a good advice but it is god only that can by his Spirit through the attonement of Jesus Christ accompanying my pray and advice & that can make it profitable unto you, for you know by the three first chapters of Romans what man is of himself and what he may be by grace Rom 3 - Rom 1:25-52 Now your earthly fathers advice is that you take your heavenly Fathers I John 3-23. advice and Seek first the kingdom of heaven and his righteousness and all other things shall be added. I should like better to hear you saying to me that doing the will of your heavenly fathers will on earth [deleted was the] as it is done in heaven by Angles was your element exactly instead of saying to put new idias of your own into form would your element exactly. O what a difference of mans ideas when god by his spirit lets light into his mind by faith regenerating grace. My Son may god for Christs sake incline you to ask for light of him and you will understand the Scriptures when you read them. And he will change your Idias wonderfully, would you be perfictly ready to meet your god were you as quickly & unexpectedly cut off from this world by death as president Lincoln was If you do not live in Christ you cannot die Christ my Son your mother & I are daily praying for all our children meet us my children at 2 o\u27clock & pray for us also. [2]We are much revived in our little church and we are all praying for each other digly read the Isa 55. prayerfully read the Bible much we cannot be benefited by it if we do not know it. And having food & raiment let us their with be content, mind not high things but condisend to man of low estates do not seek the honour that comes of man but that which comes of god. Their is nothing in the world but vanity and vexation of Spirit and the love of money is root of all evil which some have coveted & have thereby [illegible]ced themselves through with many sorrows, Try to mix with good company as much as possible & keep out of bad thing. Keep Faith & a good conscience for Christ hath died for us leaving us a good example that we should follow his steps. Keep all his commandments give up all rash gudging evil speaking, back biting whispering and do to others as you would like them to do unto you, Trust not to anything you can do or have done for Salvation but only to what Christ hath done & to what he has promised to do in you by his Sirit in Subdincing an your corruptions keep always humbling views of yourself & seek all your goodness in Christ black with sin in yourself but white by Christ impated righteousness in him, let him work all your works in you by his Spirits power and then your works will be well for there is imperfection in our own wisdom. righteous sanctification etc but all perfection in Christs I think if you had Christ and a good farm to make your bread upon you would be supplied the best I will either have to sell my farm or let it, there is nothing doing on it now receive all our loves & write soon (all well) love to [illegible]) Daniel Muir

Letter from Daniel Muir [Sr.] to Daniel [H. Muir], 1872 Jan 7.

Hickory hill, Jan. 1872.Dear Daniel. Though I seldom write to you it is no sign of want of love to you, for I do love you & your very best interests, which is the things that concern your Souls everlasting peace in Jesus for which I often pray and I would be most happy & most thankful to God, were I always sure of your Safe Keeping in Jesus in that respect, & may God grant that we may all as an unbroken family appe- ar before Him in glory at last for His Dear Sons sake and I shall praise Him for ever for it. Inclosed in this letter you will find a little Trout, it is from the repository of Dr. Charles [illegible] of Boston. God has made him the Steward of a consumpt- ives home there, where a great many poor consumptives & their children are kept free of expense, the Lord Sends in enough to Support them in answer to the Doctors prayers. There is from 40 to 50 dies annually in a converted state. it commenced about 7 years ago we have got all the annual reports, & 12 of last years reports, which along with 20 reports of the last year from George Mullers Orphan home at [Bristol?] I have Circulated along with Tracts from both places [amo?] ngst] the churches in portage, & friends & churches in the country, also. They are read with very great intrest, they have done us a deal of good, Your Mother, Anne Joanna & myself are all entred upon a life of trust. Trusting Jesus Christ as given of God & made of God unto us Wisdom, righteousness, sanctification, & redemption. We have cast the care of our Souls & our bodies upon Jesus. Who has promised to save us to the uttermost even all that call upon his name. We have taken Him as our ever- lasting place of rest, & none else & he is enough. He is the rock of ages, & our rock, we can trust him without fear of disappoint- ment for ever. For all we need for time & eternity. Christ is a fullness we cannot exhaust, & He links us to Himself & that fullness by the link of faith which He gifts to us. That on inheritance that is, and we enter upon it the moment we believe. My Dear child you may have trusted Jesus Christ to Save you from hell, but have you trusted Him with your Salvation from reigning Sin within, do you [illegible] like Paul feel your inability to conquer that sin & cry out with him, who shall deliver me from this body of death, He even Jesus can deliver us none else, O then trust Him to deliver you, callupon him then to fulfill His promise to you. For he says who so ever shall call upon the Lord Shall be Saved [illegible] this day is the day of Salvation, not [illegible] this moment not the next, We cannot abide in Jesus Christ without condemnation & follow his Spirit only until we come to Jesus, & receive of Him by our faith that power, even Himself as our deliverer. But as soon as he conquers our enemies, as our Substitute then we can abide in him at peace, & safe, without condemnation and like a grafted branch draw nourishment out of Christ Jesus always, every moment, even to great fruitfulness. Except the branch abide in the vine it cannot bring forth fruit, no more can ye except ye abide in me, for without me ye can do nothing. Your Mother & Anna joins me in kind live to you, we are glad to hear you are well, hoping you will write soon I remain yours affectionately Daniel Mui

The design of a purpose-built exergame for fall prediction and prevention for older people

Background Falls in older people represent a major age-related health challenge facing our society. Novel methods for delivery of falls prevention programs are required to increase effectiveness and adherence to these programs while containing costs. The primary aim of the Information and Communications Technology-based System to Predict and Prevent Falls (iStoppFalls) project was to develop innovative home-based technologies for continuous monitoring and exercise-based prevention of falls in community-dwelling older people. The aim of this paper is to describe the components of the iStoppFalls system. Methods The system comprised of 1) a TV, 2) a PC, 3) the Microsoft Kinect, 4) a wearable sensor and 5) an assessment and training software as the main components. Results The iStoppFalls system implements existing technologies to deliver a tailored home-based exercise and education program aimed at reducing fall risk in older people. A risk assessment tool was designed to identify fall risk factors. The content and progression rules of the iStoppFalls exergames were developed from evidence-based fall prevention interventions targeting muscle strength and balance in older people. Conclusions The iStoppFalls fall prevention program, used in conjunction with the multifactorial fall risk assessment tool, aims to provide a comprehensive and individualised, yet novel fall risk assessment and prevention program that is feasible for widespread use to prevent falls and fall-related injuries. This work provides a new approach to engage older people in home-based exercise programs to complement or provide a potentially motivational alternative to traditional exercise to reduce the risk of falling

Incorporating tumour pathology information into breast cancer risk prediction algorithms.

INTRODUCTION: Mutations in BRCA1 and BRCA2 confer high risks of breast cancer and ovarian cancer. The risk prediction algorithm BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm) may be used to compute the probabilities of carrying mutations in BRCA1 and BRCA2 and help to target mutation screening. Tumours from BRCA1 and BRCA2 mutation carriers display distinctive pathological features that could be used to better discriminate between BRCA1 mutation carriers, BRCA2 mutation carriers and noncarriers. In particular, oestrogen receptor (ER)-negative status, triple-negative (TN) status, and expression of basal markers are predictive of BRCA1 mutation carrier status. METHODS: We extended BOADICEA by treating breast cancer subtypes as distinct disease end points. Age-specific expression of phenotypic markers in a series of tumours from 182 BRCA1 mutation carriers, 62 BRCA2 mutation carriers and 109 controls from the Breast Cancer Linkage Consortium, and over 300,000 tumours from the general population obtained from the Surveillance Epidemiology, and End Results database, were used to calculate age-specific and genotype-specific incidences of each disease end point. The probability that an individual carries a BRCA1 or BRCA2 mutation given their family history and tumour marker status of family members was computed in sample pedigrees. RESULTS: The cumulative risk of ER-negative breast cancer by age 70 for BRCA1 mutation carriers was estimated to be 55% and the risk of ER-positive disease was 18%. The corresponding risks for BRCA2 mutation carriers were 21% and 44% for ER-negative and ER-positive disease, respectively. The predicted BRCA1 carrier probabilities among ER-positive breast cancer cases were less than 1% at all ages. For women diagnosed with breast cancer below age 50 years, these probabilities rose to more than 5% in ER-negative breast cancer, 7% in TN disease and 24% in TN breast cancer expressing both CK5/6 and CK14 cytokeratins. Large differences in mutation probabilities were observed by combining ER status and other informative markers with family history. CONCLUSIONS: This approach combines both full pedigree and tumour subtype data to predict BRCA1/2 carrier probabilities. Prediction of BRCA1/2 carrier status, and hence selection of women for mutation screening, may be substantially improved by combining tumour pathology with family history of cancer.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

The use of evidence in public governmental reports on health policy: an analysis of 17 Norwegian official reports (NOU)

<p>Abstract</p> <p>Background</p> <p>Governments increasingly require policy documents to be evidence-based. This paper analyses the use of scientific evidence in such documents by reviewing reports from government-appointed committees in Norway to assess the committees' handling of questions of effect.</p> <p>Methods</p> <p>This study uses the 'Index of Scientific Quality' (ISQ) to analyse all Norwegian official reports (NOUs) that were: (1) published by the Norwegian Ministry of Health and Care Services during 1994-1998 (N = 20); and (2) concerned with questions of effect either because these were included in the mandate or as a result of the committee's interpretation of the mandate. The ISQ is based on scientific criteria common in all research concerning questions of effect. The primary outcome measure is an ISQ score on a five-point scale.</p> <p>Results</p> <p>Three reports were excluded because their mandates, or the committees' interpretations of them, did not address questions of effect. For the remaining 17 NOUs in our study, overall ISQ scores were low for systematic literature search and for explicit validation of research. Two reports had an average score of three or higher, while scores for five other reports were not far behind. How committees assessed the relevant factors was often unclear.</p> <p>Conclusion</p> <p>The reports' evaluations of health evidence in relation to questions of effect lacked transparency and, overall, showed little use of systematic processes. A systematic, explicit and transparent approach, following the standards laid down in the ISQ, may help generate the evidence-based decision-making that Norway, the UK, the EU and the WHO desire and seek. However, policy-makers may find the ISQ criteria for assessing the scientific quality of a report too narrow to adequately inform policy-making.</p

Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

The inclusive and dijet production cross-sections have been measured for jets containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The measurements use data corresponding to an integrated luminosity of 34 pb^-1. The b-jets are identified using either a lifetime-based method, where secondary decay vertices of b-hadrons in jets are reconstructed using information from the tracking detectors, or a muon-based method where the presence of a muon is used to identify semileptonic decays of b-hadrons inside jets. The inclusive b-jet cross-section is measured as a function of transverse momentum in the range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet cross-section is measured as a function of the dijet invariant mass in the range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets and the angular variable chi in two dijet mass regions. The results are compared with next-to-leading-order QCD predictions. Good agreement is observed between the measured cross-sections and the predictions obtained using POWHEG + Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet cross-section. However, it does not reproduce the measured inclusive cross-section well, particularly for central b-jets with large transverse momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final version published in European Physical Journal

Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV

The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration