Synthetic Geopolymers for Controlled Delivery of Oxycodone: Adjustable and Nanostructured Porosity Enables Tunable and Sustained Drug Release

In this article we for the first time present a fully synthetic mesoporous geopolymer drug carrier for controlled release of opioids. Nanoparticulate precursor powders with different Al/Si-ratios were synthesized by a sol-gel route and used in the preparation of different geopolymers, which could be structurally tailored by adjusting the Al/Si-ratio and the curing temperatures. In particular, it was shown that the pore sizes of the geopolymers decreased with increasing Al/Si ratio and that completely mesoporous geopolymers could be produced from precursor particles with the Al/Si ratio 2∶1. The mesoporosity was shown to be associated with a sustained and linear in vitro release profile of the opioid oxycodone. A clinically relevant release period of about 12 h was obtained by adjusting the size of the pellets. The easily fabricated and tunable geopolymers presented in this study constitute a novel approach in the development of controlled release formulations, not only for opioids, but whenever the clinical indication is best treated with a constant supply of drugs and when the mechanical stability of the delivery vehicle is crucial

Effects of sintering time on translucency and color of translucent zirconia ceramics.

OBJECTIVE To investigate the effect of sintering time on translucency and color of translucent zirconia ceramics. MATERIALS AND METHODS Sixty translucent zirconia (5Y-TZP) specimens (12 × 1.6 mm, Katana (KAT) and NexxZr (NEX)) were divided into six groups (n = 10) according to sintering time; 1, 2 (specified by manufacturer-control), and 3 hs. Color differences (ΔEab) within same material when sintered using different times and between materials when same sintering time was used were calculated, as well as translucency parameters (TP) after the use of each sintering time. Data for ΔEab and TP were analyzed with two-way ANOVAs, pairwise comparisons, and Fisher's LSD Test (Post-hoc). RESULTS When 1 or 3 h were used, color difference from the color of specimens when manufacturer-specified time (2 h) was used was similar for both KAT and NEX. ΔEab values of NEX were significantly higher than KAT when sintered for 1 or 3 h (P < 0.001). TP increased for KAT when sintered for 1 h, and was higher than NEX. TP for NEX increased when sintered for 3 h (P < 0.001), but was not significantly different than that of KAT. CONCLUSIONS Effect of 1 or 3-h sintering on color was similar for both zirconias. For NEX, this effect resulted in greater differences from the color of specimens when manufacturer-specified time was used. Sintering for 1 h increased the translucency of KAT. CLINICAL SIGNIFICANCE When high translucency is desired, clinicians may prefer 1-h sintering for KAT zirconia. When lower translucency is desired, 3-h sintering for NEX can be used. However, for NEX, the color after 1- or 3-h sintering was different than the color obtained with manufacturer-specified time, and this difference may affect the final color of restoration compared to the final color when manufacturer-specified time is used