Adenylate cyclase activity in the fetal and the early postnatal inner ear of the mouse

The adenylate cyclase activity was analyzed in fetal, early postnatal and adult inner ears of the CBA/CBA mouse and also in approximately one month old inner ears from Shaker -1 and Shaker -2 mice. A comparison was made with the maturation of potassium levels in endolymph as investigated with the X-ray energy dispersive technique.Adenylate cyclase activity in the developing normal inner ear shows two significant periods of increases: from the 16th to the 19th gestational day in both the cochlear and vestibular parts of the labyrinth, and from birth to day 6 after birth in the lateral wall tissues of the scala media. During the first period the anatomical boundaries of the secretory epithelia are developing. The postnatal rise in adenylate cyclase activity correlates with the morphological maturation of stria vascularis at the cellular and subcellular levels and the rise in potassium content of endolymph. The rise of enzyme activity in the cochlea during the maturation of endolymph supports a link between adenylate cyclase and the control of inner ear fluids. Adenylate cyclase activity in stria vascularis/spiral ligament of Shaker -1 and Shaker -2 mice were at normal levels and correlated better with the rather normal morphology of the tissues than the abnormal composition of endolymph in these mutants.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24431/1/0000703.pd

Principles of Hand Fracture Management

The hand is essential in humans for physical manipulation of their surrounding environment. Allowing the ability to grasp, and differentiated from other animals by an opposing thumb, the main functions include both fine and gross motor skills as well as being a key tool for sensing and understanding the immediate surroundings of their owner

In vitro study of the toxicity of a composite resin, silver amalgam, and Cavit.

Cytotoxicity of a composite resin (Restodent), suggested for use as a retrograde endodontic filling material, was evaluated in vitro and compared with silver amalgam and Cavit. Materials were evaluated freshly prepared and after 1 and 7 days setting at 37°C and 100% humidity. Results showed that Restodent was more toxic than silver amalgam. Cavit had no toxic effect. Although Restodent was reported to have better sealing properties than silver amalgam in vitro, the latter, due to its lower toxicity, is still the material of choice for retrograde root canal filling.King Saud Universit