19 research outputs found
Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis
Endometriosis is a common chronic inflammatory condition in which endometrial tissue appears outside the uterine cavity. Because ectopic endometriosis cells express both estrogen and progesterone (P4) receptors, they grow and undergo cyclic proliferation and breakdown similar to the endometrium. This debilitating gynecological disease affects up to 15% of reproductive aged women. Despite many years of research, the etiopathogenesis of endometrial lesions remains unclear. Retrograde transport of the viable menstrual endometrial cells with retained ability for attachment within the pelvic cavity, proliferation, differentiation and subsequent invasion into the surrounding tissue constitutes the rationale for widely accepted implantation theory. Accordingly, the most abundant cells in the endometrium are endometrial stromal cells (EnSCs). These cells constitute a particular population with clonogenic activity that resembles properties of mesenchymal stem/stromal cells (MSCs). Thus, a significant role of stem cell-based dysfunction in formation of the initial endometrial lesions is suspected. There is increasing evidence that the role of epigenetic mechanisms and processes in endometriosis have been underestimated. The importance of excess estrogen exposure and P4 resistance in epigenetic homeostasis failure in the endometrial/endometriotic tissue are crucial. Epigenetic alterations regarding transcription factors of estrogen and P4 signaling pathways in MSCs are robust in endometriotic tissue. Thus, perspectives for the future may include MSCs and EnSCs as the targets of epigenetic therapies in the prevention and treatment of endometriosis. Here, we reviewed the current known changes in the epigenetic background of EnSCs and MSCs due to estrogen/P4 imbalances in the context of etiopathogenesis of endometriosis
Evaluating time between birth to cry or bag and mask ventilation using mobile delivery room timers in India: the NICHD Global Network’s Helping Babies Breathe Trial
Use of Rolling Circle Amplification to Rapidly Identify Species of Cladophialophora Potentially Causing Human Infection
A Five-Year Survey of Dematiaceous Fungi in a Tropical Hospital Reveals Potential Opportunistic Species
In Vitro Investigation of Antifungal Activity of Allicin Alone and in Combination with Azoles Against Candida Species
Measuring Inequality of Opportunity for the Backward Communities:Regional Evidence from the Indian Labour Market
Le quartier Graslin et ses acteurs.
Le plan de Nantes signé en 1789 par Nicolas Sauzeau, exprime bien la dualité essentielle du quartier dont Jean-Joseph-Louis Graslin s’est fait le promoteur depuis une dizaine d’années : un lotissement privé articulé avec le plan de la ville (fig. 48). La pleine valeur de l’opération de Graslin ne pouvait éviter une concertation avec la communauté de ville qui prenne en considération son projet annoncé comme « vues patriotiques ». Si, dans plusieurs mémoires justificatifs et défensifs, l’écono..