An additional 2'-ribofuranose residue at a specific position of the DNA primer prevents its elongation by HIV-1 reverse transcriptase

Oligodeoxynucleotides containing 2'-O-beta-D-ribofuranosyladenosine were prepared and used as modified primers in RNA-templated DNA synthesis catalyzed by HIV reverse transcriptase. It was shown that the additional 2'-ribofuranose residue in specific position of primer prevents its elongation.status: publishe

Interaction of HIV-1 reverse transcriptase with modified oligonucleotide primers containing 2'-O-beta-D-ribofuranosyladenosine

Modified synthetic oligodeoxyribonucleotides containing 2'-O-beta-D-ribofuranosyladenosine were used as primers in the RNA-dependent DNA synthesis catalyzed by HIV-1 reverse transcriptase. The degree of elongation of the primers depends on the position of the additional ribose unit, its presence in the specific position of the primer (-4) (and only in it) completely preventing elongation. Computer-modeled binding of the modified primers to the active site of reverse transcriptase demonstrated that steric hindrances arising from the interaction of the additional ribose residue with the reverse transcriptase region 262-270 interacting with the minor groove of the DNA substrate prevents elongation in the above mentioned case.status: publishe

Intermediate mass dimuons in NA38/NA50

The NA38/NA50 experiments have measured, at the CERN SPS, the dimuon production in proton-nucleus and nucleus-nucleus collisions. In this paper it is shown that the mass continuum between the phi and the J/psi can be satisfactorily described, after having removed the combinatorial background due to uncorrelated pi and K decays, as a sum of two contributions, namely the Drell-Yan process and the semi-leptonic decay of pairs of charmed mesons, whose mass shape in the acceptance of the experiment has been evaluated using PYTHIA. However, in order to describe the A-B (namely S-U and Pb-Pb) mass spectra, the dimuon yield from open charm decays, which in p-A collisions is found to be consistent with direct open charm measurements from other CERN and FNAL experiments, has to be enhanced with respect to a linear extrapolation of p-A results. The size of the enhancement smoothly increases from peripheral S-U to central Pb-Pb interactions, reaching a factor similar to 3 in central Pb-Pb collisions. The pr distributions of the events in the mass continuum are also compatible with the hypothesis of open charm enhancement in A-B collisions. RI Alexa, Calin/F-6345-2010; Rato Mendes, Pedro/F-8827-201

Measurements of hadron production in π++C and π++Be interactions at 60 GeV/c

Precise knowledge of hadron production rates in the generation of neutrino beams is necessary for accelerator-based neutrino experiments to achieve their physics goals. NA61/SHINE, a large-acceptance hadron spectrometer, has recorded hadron+nucleus interactions relevant to ongoing and future long-baseline neutrino experiments at Fermi National Accelerator Laboratory. This paper presents three analyses of interactions of 60  GeV/c π+ with thin, fixed carbon and beryllium targets. Integrated production and inelastic cross sections were measured for both of these reactions. In an analysis of strange, neutral hadron production, differential production multiplicities of K0S, Λ and ¯Λ were measured. Lastly, in an analysis of charged hadron production, differential production multiplicities of π+, π−, K+, K− and protons were measured. These measurements will enable long-baseline neutrino experiments to better constrain predictions of their neutrino flux in order to achieve better precision on their neutrino cross section and oscillation measurements

Measurements of π± , K± and proton double differential yields from the surface of the T2K replica target for incoming 31 GeV/c protons with the NA61/SHINE spectrometer at the CERN SPS

Measurements of the π±, K±, and proton double differential yields emitted from the surface of the 90-cm-long carbon target (T2K replica) were performed for the incoming 31 GeV/c protons with the NA61/SHINE spectrometer at the CERN SPS using data collected during 2010 run. The double differential π± yields were measured with increased precision compared to the previously published NA61/SHINE results, while the K± and proton yields were obtained for the first time. A strategy for dealing with the dependence of the results on the incoming proton beam profile is proposed. The purpose of these measurements is to reduce significantly the (anti)neutrino flux uncertainty in the T2K long-baseline neutrino experiment by constraining the production of (anti)neutrino ancestors coming from the T2K target

ALICE: Physics Performance Report, Volume II

ALICE is a general-purpose heavy-ion experiment designed to study the physics of strongly interacting matter and the quark-gluon plasma in nucleus-nucleus collisions at the LHC. It currently involves more than 900 physicists and senior engineers, from both the nuclear and high-energy physics sectors, from over 90 institutions in about 30 countries. The ALICE detector is designed to cope with the highest particle multiplicities above those anticipated for Pb-Pb collisions (dN(ch)/dy up to 8000) and it will be operational at the start-up of the LHC. In addition to heavy systems, the ALICE Collaboration will study collisions of lower-mass ions, which are a means of varying the energy density, and protons (both pp and pA), which primarily provide reference data for the nucleus-nucleus collisions. In addition, the pp data will allow for a number of genuine pp physics studies. The detailed design of the different detector systems has been laid down in a number of Technical Design Reports issued between mid-1998 and the end of 2004. The experiment is currently under construction and will be ready for data taking with both proton and heavy-ion beams at the start-up of the LHC. Since the comprehensive information on detector and physics performance was last published in the ALICE Technical Proposal in 1996, the detector, as well as simulation, reconstruction and analysis software have undergone significant development. The Physics Performance Report (PPR) provides an updated and comprehensive summary of the performance of the various ALICE subsystems, including updates to the Technical Design Reports, as appropriate. The PPR is divided into two volumes. Volume I, published in 2004 (CERN/LHCC 2003-049, ALICE Collaboration 2004 J. Phys. G: Nucl. Part. Phys. 30 1517-1763), contains in four chapters a short theoretical overview and an extensive reference list concerning the physics topics of interest to ALICE, the experimental conditions at the LHC, a short summary and update of the subsystem designs, and a description of the offline framework and Monte Carlo event generators. The present volume, Volume II, contains the majority of the information relevant to the physics performance in proton-proton, proton-nucleus, and nucleus-nucleus collisions. Following an introductory overview, Chapter 5 describes the combined detector performance and the event reconstruction procedures, based on detailed simulations of the individual subsystems. Chapter 6 describes the analysis and physics reach for a representative sample of physics observables, from global event characteristics to hard processes