Interpreting interpolation: the pattern of interpolation errors in digital surface models derived from laser scanning data

Errors within height models have, in the past, been communicated in terms of global measures ofaccuracy for the model. Such quantification ignores the spatial structure of errors across thesurface, hindering subsequent analysis. This paper demonstrates the importance ofunderstanding the spatial structure of error using, as an example, the creation of a DigitalSurface Model (DSM) from laser scanner data

Etiology and Pharmacology of Neuropathic Pain

Injury to or disease of the nervous system can invoke chronic and sometimes intractable neuropathic pain. Many parallel, interdependent, and time-dependent processes, including neuroimmune interactions at the peripheral, supraspinal, and spinal levels, contribute to the etiology of this "disease of pain." Recent work emphasizes the roles of colony-stimulating factor 1, ATP, and brain-derived neurotrophic factor. Excitatory processes are enhanced, and inhibitory processes are attenuated in the spinal dorsal horn and throughout the somatosensory system. This leads to central sensitization and aberrant processing such that tactile and innocuous thermal information is perceived as pain (allodynia). Processes involved in the onset of neuropathic pain differ from those involved in its long-term maintenance. Opioids display limited effectiveness, and less than 35% of patients derive meaningful benefit from other therapeutic approaches. We thus review promising therapeutic targets that have emerged over the last 20 years, including Na+, K+, Ca2+, hyperpolarization-activated cyclic nucleotide-gated channels, transient receptor potential channel type V1 channels, and adenosine A3 receptors. Despite this progress, the gabapentinoids retain their status as first-line treatments, yet their mechanism of action is poorly understood. We outline recent progress in understanding the etiology of neuropathic pain and show how this has provided insights into the cellular actions of pregabalin and gabapentin. Interactions of gabapentinoids with theα2δ-1 subunit of voltage-gated Ca2+channels produce multiple and neuron type-specific actions in spinal cord and higher centers. We suggest that drugs that affect multiple processes, rather than a single specific target, show the greatest promise for future therapeutic development

The Anti-Allodynic Gabapentinoids: Myths, Paradoxes, and Acute Effects

The gabapentinoids (pregabalin and gabapentin) are first line treatments for neuropathic pain. They exert their actions by binding to the α2δ accessory subunits of voltage-gated Ca2+ channels. Because these subunits interact with critical aspects of the neurotransmitter release process, gabapentinoid binding prevents transmission in nociceptive pathways. Gabapentinoids also reduce plasma membrane expression of voltage-gated Ca2+ channels but this may have little direct bearing on their therapeutic actions. In animal models of neuropathic pain, gabapentinoids exert an anti-allodynic action within 30 minutes but most of their in vitro effects are 30-fold slower, taking at least 17 hours to develop. This difference may relate to increased levels of α2δ expression in the injured nervous system. Thus, in situations where α2δ is experimentally upregulated in vitro, gabapentinoids act within minutes to interrupt trafficking of α2δ subunits to the plasma membrane within nerve terminals. When α2δ is not up-regulated, gabapentinoids act slowly to interrupt trafficking of α2δ protein from cell bodies to nerve terminals. This improved understanding of the mechanism of gabapentinoid action is related to their slowly developing actions in neuropathic pain patients, to the concept that different processes underlie the onset and maintenance of neuropathic pain and to the use of gabapentinoids in management of postsurgical pain

Detection of high levels of congenital transmission of toxoplasma gondii in natural urban populations of mus domesticus

The relative importance of different transmission routes of Toxoplasma gondii has been a matter for debate. This ubiquitous parasite is generally thought to be transmitted by infective oocysts excreted by the definitive host, the cat. Ingestion of undercooked meat has also been considered an important route of transmission in many mammals while congenital transmission has generally been considered relatively rare. Experimental studies demonstrate the ability of T. gondii to be transmitted congenitally, but few studies have investigated the frequency of this transmission route in natural populations. We use PCR amplification of the SAG1 gene to investigate the frequency of congenital transmission in a wild population of mice (Mus domesticus) and show that congenital transmission is occurring in 75% of pregnancies in this population. Furthermore, for infected pregnant mice, transmission occurs to at least one foetus in 100% of cases while variable penetrance of congenital infection is observed. These high levels of congenital transmission in this wild population of mice, taken together with other recent data on congenital transmission in sheep, suggests that this phenomenon might be more widespread than previously thought

Experimental techniques for ductile damage characterisation

Ductile damage in metallic materials is caused by the nucleation, growth and coalesce of voids and micro-cracks in the metal matrix when it is subjected to plastic strain. A considerable number of models have been proposed to represent ductile failure focusing on the ultimate failure conditions; however, only some of them study in detail the whole damage accumulation process. The aim of this work is to review experimental techniques developed by various authors to measure the accumulation of ductile damage under tensile loads. The measurement methods reviewed include: stiffness degradation, indentation, microstructure analysis, ultrasonic waves propagation, X-ray tomography and electrical potential drop. Stiffness degradation and indentation techniques have been tested on stainless steel 304L hourglass-shaped samples. A special interest is placed in the Continuum Damage Mechanics approach (CDM) as its equations incorporate macroscopic parameters that can represent directly the damage accumulation measured in the experiments. The other main objective lies in identifying the strengths and weaknesses of each technique for the assessment of materials subjected to different strain-rate and temperature conditions

Luminosities of AGB Variables

The prevailing evidence suggests that most large-amplitude AGB variables follow the period luminosity (PL) relation that has been established for Miras in the LMC and galactic globular clusters. Hipparcos observations indicate that most Miras in the solar neighbourhood are consistent with such a relation. There are two groups of stars with luminosities that are apparently greater than the PL relation would predict: (1) in the LMC and SMC there are large amplitude variables, with long periods, P> 420 days, which are probably undergoing hot bottom burning, but which are very clearly more luminous than the PL relation (these are visually bright and are likely to be among the first stars discovered in more distant intermediate age populations); (2) in the solar neighbourhood there are short period, P<235 days, red stars which are probably more luminous than the PL relation. Similar short-period red stars, with high luminosities, have not been identified in the Magellanic Clouds.Comment: 8 pages, 2 figure, to be published in Mass-Losing Pulsating Stars and their Circumstellar Matter, Y. Nakada & M. Honma (eds) Kluwer ASSL serie

Energy Performance Contracting - Is it time to check the small print?

Energy Performance Contracting has been suggested as a key strategy to increase energy efficiency retrofits of existing building stock: reducing the uncertainty of returns on the investment by guaranteeing the level of energy savings that will result and thus making energy efficiency investment significantly more attractive. However, in order for this potential to be realised, investors need to have confidence in the level of protection offered by the guarantee. This study explores the consequences of alternative approaches to measuring and verifying savings due to a lighting retrofit project in a hypothetical UK school. It finds that the hours of lighting use can significantly affect the final savings. In most cases a significant increase in gas consumption is seen which is ignored by several of the measurement options leading to the potential for a loss of confidence in the value of the savings guarantee if a more transparent approach is not taken by the contractor

Braking characteristics during cutting and pivoting in female soccer players

Biomechanical studies into changing direction focus on final contact (FC), whilst limited research has examined penultimate contact (PEN). The aim of this study was to explore the kinematic and kinetic differences between PEN and FC of cutting and pivoting in 22 female soccer players (mean ± SD; age: 21 ± 3.1 years, height: 1.68 ± 0.07 m, mass: 58.9 ± 7.3 kg). Furthermore, the study investigated whether horizontal force-time characteristics during PEN were related to peak knee abduction moments during FC. Three dimensional motion analyses of cutting and pivoting on the right leg were performed using Qualysis ‘Pro-reflex’ infrared cameras (240Hz). Ground reaction forces (GRF) were collected from two AMTI force platforms (1200Hz) to examine PEN and FC. Both manoeuvres involved significantly (P < 0.05) greater knee joint flexion angles, peak horizontal GRF, but lower average horizontal GRF during PEN compared to FC. Average horizontal GRF during PEN (R = -0.569, R2 = 32%, P = 0.006) and average horizontal GRF ratio (R = 0.466, R2 = 22%, P = 0.029) were significantly related to peak knee abduction moments during the FC of cutting and pivoting, respectively. The results indicate PEN during pre-planned changing direction helps reduce loading on the turning leg where there is greater risk of injuries to knee ligaments