4 research outputs found
Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic protease
We have extended a highly flexible method for rapidly assembling aspartic protease inhibitors to produce symmetric and
asymmetric monohydroxyethylene peptidomimetics. This method is based on the prior synthesis of the central non-cleavable peptide-
bond isostere [NH2\u2013P1cP10\u2013NH2; c=hydroxyethylene isostere, HNCH(Bz)CHOHCH2CH(Bz)NH], with the possibility of
accurately controlling its stereochemistry (S,S,S or S,R,S), and subsequently adding appropriate flanking units, chosen from commercially
available amino acids, aromatic carboxylic acids, or phenoxyacetic acid (Poa) derivatives. The method was used to make
asymmetric inhibitors of general formula Kyn-Xaa-PhecPhe-dmPoa, (Kyn=kynurenic acid, Xaa=Val, Thr or d-thienylglycine,
Mr=716\u2013754) and symmetric inhibitors of formula xPoa-PhecPhe-xPoa (xPoa=Poa or dimethyl-, hydroxy-, formyl- or acetyl-
Poa, Mr=553\u2013609), with logPo/w values ranging from 4.1 to 7.6. Inhibition of HIV-PR did not depend on the stereochemistry of
the hydroxyl group, while it depended markedly on the substituents present on the Poa residues, with dmPoa being preferred over
Poa or its more hydrophilic derivatives. Conversely, inhibition of Candida albicans Sap2 was higher for the S,S,S epimers, and Poa
or its hydrophilic derivatives were preferred over dmPoa
Solid double microemulsions for improved absorption of scarcely bioavailable drugs
Solid double microemulsions for improved absorption of scarcely bioavailable drug