Synthesis and bioactivity evaluation of new phenyl <i>N,N′-</i>phenylphosphorodiamidates

<p></p> <p>A series of new biologically active phenyl N,N<b>^′-</b>phenyl phosphorodiamidates were synthesized by reacting phenyl phenylphosphoramidochoridate with various amines. All the newly synthesized compounds <b>3a-j</b> were tested for their antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H₂O₂) and nitric oxide (NO) methods. In all the three methods the compounds <b>3c</b> (phenyl N-(6-methoxy-1,3-benzothiazol-2-yl)-N′-phenyl-phosphorodiamidate) and <b>3e</b> (phenyl N-(5-ethyl-1,3,4-thiadiazol-2-yl)-N′-phenylphosphorodiamidate) showed good radical scavenging activity.</p