A Prospective study on the assessment of risk factors for type 2 diabetes mellitus in outpatients department of a south Indian tertiary care hospital: A case-control study

Background: Type 2 diabetes mellitus (T2DM) is the most general type of diabetes. In India, the risk factors (modifiable and nonmodifiable) for diabetes are seen more frequently and there is lack of perception about this problem.Objective: The objective of the study was to assess the incidence and risk factors for T2DM in a south Indian tertiary care hospital.Materials and Methods: A prospective study was conducted on 1161 subjects (with or without T2DM) from November 2014 to April 2015 in general medicine department of Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Andhra Pradesh, south India. Chi-square test was used to evaluate the incidence of T2DM and odds ratios were calculated in univariate logistic regression analysis for risk factors.Results: T2DM was significantly higher in the subjects of age above 41 years (86.3%, P<0.0001), married (95.4%, P=0.002), educators (degree and above, 13.2%, P<0.0001), known family history (50.8%, P<0.0001), BMI (>25 kg/m2,58.7%; P<0.0001), Govt. job holders (5.5%, P<0.0001), business people (12%, P<0.0001), house wives (38.3%, P<0.0001), high economic status (34.9%, P<0.0004), preexisting hypertension (40.2%, P<0.0001), urban residence (50.4%, P<0.0001), physical inactivity (45.3%, P<0.001), stress (61.0%, P=0.01), consumption of tea and coffee (daily thrice or more, 6.3%, P=0.0003), soft drinks (weekly thrice or more, 4%, P=0.0008) and junk foods (weekly thrice or more 2.6%, P=0.025) than non-diabetic subjects. Univariate logistic regression analysis showed that the age (above 41 years), marital status, education, family history, BMI (>25 kg/m2), high economic status, co-morbidities (hypertension and thyroid disorders) urban residence, physical inactivity, stress, consumption of tea and coffee (daily thrice or more), soft drinks (weekly thrice or more) and junk foods are the significantly risk factors for T2DM.Conclusion: The present study results suggested that beware of hypertension, thyroids disorders, physical inactivity, stress, soft drinks and junk foods, which are major risk factors of T2DM.Â

Quercetin declines plasma exposure of metoprolol tartrate in the rat model

The study was undertaken to evaluate the effect of quercetin on the pharmacokinetics of Metoprolol tartrate. A single dose in vivo pharmacokinetic study was carried out in rat models. In this study, rats were treated with quercetin (10 mg/kg) and metoprolol tartrate (20 mg/kg) orally and blood samples were collected 0, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 8, 12 h post treatment. Plasma concentration of metoprolol tartrate was estimated using reverse phase-high-performance liquid chromatography method. Area under the plasma concentration-time curve (AUC 0-12 ) of metoprolol has significantly (P < 0.001) decreased by 9.8 times in the metoprolol and quercetin combination group (9434.65 ± 3525.02) when compared with AUC 0-12 metoprolol of metoprolol-alone treated group (962.17 ± 242.81). AUC 0-∞ of metoprolol has significantly (P < 0.001) decreased by 14.9 times in the combination group (16670.79 ± 12129.06) in comparison to AUC 0-∞ of metoprolol of metoprolol-alone treated group (1113.68 ± 441.83). the results obtained herein indicate that quercetin remarkably declines the plasma exposure of metoprolol when concomitantly administered by oral route

Analysis of Attacks and Security Requirements for Wireless Body Area Networks-A Systematic Literature Review

Wireless Body Area Networks are gaining popularity in healthcare applications due to recent advances in sensor technology, integrated circuits, and wireless communication. These systems need to ensure that data is protected during collection, transmission, processing and storage. Currently, no complete solution exists for ensuring data is protected while also meeting regulatory security requirements for wireless body area network applications. To develop effective solutions, it is necessary to explore the attacks and security requirements of wireless body area network applications. There is no comprehensive list of attacks and security requirements. This paper will present a systematic literature review of potential attacks and security requirements for ensuring data security in wireless body area networks