Level Crossing Analysis of the Stock Markets

We investigate the average frequency of positive slope $\nu_{\alpha}^{+}$, crossing for the returns of market prices. The method is based on stochastic processes which no scaling feature is explicitly required. Using this method we define new quantity to quantify stage of development and activity of stocks exchange. We compare the Tehran and western stock markets and show that some stocks such as Tehran (TEPIX) and New Zealand (NZX) stocks exchange are emerge, and also TEPIX is a non-active market and financially motivated to absorb capital.Comment: 6 pages and 4 figure

JUMPING STRATEGIES IN A VOLLEYBALL AND A BALLET SPECIFIC JUMP

INTRODUCTION The performance of a maximal vertical jump fram a static preparatory position (SQJ) or starting with a counter movement (CMJ) implies transformation of rotation about the hip, knee and ankle joints to a maximal translatory movement. Different strategies have been proposed for this transformation. Previously both sequential and simullaneous strategies have been proposed as optimal for maximal vertical jumping (1 & 2). The purpose of this study was to analyze ]umping strategies in a sport and dance specific maximal vertical jump. The hypothesis was that the technical demands of the Jumps would preset the strategy. Six male subjects participated in the study three professional ballet dancers and three elite volleyball players. In the ballet specific jump (BSJ) the legs were outward rotated, one foot was placed in front of and close to the other foot and the upper body kept upright. Three elite volleyball players performed the jump used for the smash (VSJ) including a three step preliminary run up and a farcefull arm swing. Afterwards all six subjects performed SQJ and CMJ. The ]umps were recorded on high speed film (500Hz) combined with registrations trom an AMTI force platform and EMG recordings from the major lower extremity muscles Net joint moments and joint work ware calculated by inverse dynamics. The strategy of the jumps was determined on the basis of angular kinematics and the pattern of nel joint moments of the two dominant joints RESULTS For BSJ the jumping height (h) was 0.22O.28m.The war!< contribution from the knee and ankle joint were 50-70% and 47-63% of the total work respectively while the work at the hip joint showed a negative contribution of 13-17% caused by a net hip flexor moment. Because of the specific ballet position the hip extension took place in the frontal plane and mgluteus maximus could not contribute to the extension. The concentric activity in mrectus femoris could partly explain the hip flexor moment. The knee and ankle joint initiated the extension phase simultaneously and the net joint moments peaked also simultaneously Therefore, the strategy could be defined as simultaneous. For VSJ h was 0.310.45m. The work contribution fram the knee and hip joints were 22-60% and 35-62% of the total work respectively. The hip joint began the extension phase before the body center of mass had reached its lowest position (sn The knee extension began 40-100ms after s.j. The peaks of the net joint moments of the hip and knee showed a similar pattern. Accordingly, the strategy could be defined as sequentiaL The sequential joint extension could partly be explained by the forcefull armswing pressing down and giving negative momentum in the downward phase and by this delaying the knee extension. In SQJ and CMJ h was 0.22-0.36m and 0.33-0AOm. The work contribution from the knee was 64.5%(SE 5.9) and 76.0% (SE 9.2) and from the hip 18.8% (SE 5.8) and 133% (SE 8.7). One ballet dancer and one volleyball player performed SQJ and CMJ with a simultaneous strategy while the otller four subjects used a sequential strategy. CONCLUSION In a maximal vertical jump fram ballet and from volleyball the technical demands preset the jumping strategy. When the subjects were asked to perform SQJ and CMJ the choice of strategy seemed individual and not connected to the training background. REFERENCES (1) Hudson, J.L. (1986). Med Sci. Sports Exerc, 18,242-251 (2) Babbert, M.F. & van lngen Schenau, G.J. (1986). J Biomechanics, 21, 249•26

Transport methods and interactions for space radiations

A review of the program in space radiation protection at the Langley Research Center is given. The relevant Boltzmann equations are given with a discussion of approximation procedures for space applications. The interaction coefficients are related to solution of the many-body Schroedinger equation with nuclear and electromagnetic forces. Various solution techniques are discussed to obtain relevant interaction cross sections with extensive comparison with experiments. Solution techniques for the Boltzmann equations are discussed in detail. Transport computer code validation is discussed through analytical benchmarking, comparison with other codes, comparison with laboratory experiments and measurements in space. Applications to lunar and Mars missions are discussed

Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors : a new toolbox to study the role of IL-1 in health and disease

The pro-inflammatory cytokine interleukin-1 (IL-1) plays a key role in many physiological processes and during the inflammatory and immune response to most common diseases. IL-1 exists as two agonists, IL-1α and IL-1β that bind to the only signaling IL-1 type 1 receptor (IL-1R1), while a second decoy IL-1 type 2 receptor (IL-1R2) binds both forms of IL-1 without inducing cell signaling. The field of immunology and inflammation research has, over the past 35 years, unraveled many mechanisms of IL-1 actions, through in vitro manipulation of the IL-1 system or by using genetically engineered mouse models that lack either member of the IL-1 family in ubiquitous constitutive manner. However, the limitation of global mouse knockout technology has significantly hampered our understanding of the precise mechanisms of IL-1 actions in animal models of disease. Here we report and review the recent generation of new conditional mouse mutants in which exons of Il1a, Il1b, Il1r1, and Il1r2 genes flanked by loxP sites (fl/fl) can be deleted in cell-/tissue-specific constitutive or inducible manner by Cre recombinase expression. Hence, IL-1αfl/fl, IL-1βfl/fl, IL-1R1fl/fl, and IL-1R2fl/fl mice constitute a new toolbox that will provide a step change in our understanding of the cell-specific role of IL-1 and its receptor in health and disease and the potential development of targeted IL-1 therapies

Enzyme prodrug therapy achieves site-specific, personalized physiological responses to the locally produced nitric oxide

Nitric oxide (NO) is a highly potent but short-lived endogenous radical with a wide spectrum of physiological activities. In this work, we developed an enzymatic approach to the site-specific synthesis of NO mediated by biocatalytic surface coatings. Multilayered polyelectrolyte films were optimized as host compartments for the immobilized β-galactosidase (β-Gal) enzyme through a screen of eight polycations and eight polyanions. The lead composition was used to achieve localized production of NO through the addition of β-Gal–NONOate, a prodrug that releases NO following enzymatic bioconversion. The resulting coatings afforded physiologically relevant flux of NO matching that of the healthy human endothelium. The antiproliferative effect due to the synthesized NO in cell culture was site-specific: within a multiwell dish with freely shared media and nutrients, a 10-fold inhibition of cell growth was achieved on top of the biocatalytic coatings compared to the immediately adjacent enzyme-free microwells. The physiological effect of NO produced via the enzyme prodrug therapy was validated ex vivo in isolated arteries through the measurement of vasodilation. Biocatalytic coatings were deposited on wires produced using alloys used in clinical practice and successfully mediated a NONOate concentration-dependent vasodilation in the small arteries of rats. The results of this study present an exciting opportunity to manufacture implantable biomaterials with physiological responses controlled to the desired level for personalized treatment