Parkinson\u27s Disease, Amantadine Hydrochloride Therapy and Dopa Metabolites

In an attempt to clarify the effect of amantadine hydrochloride therapy in Parkinson\u27s disease, dopa metabolites were measured in the urine of 15 patients who were taking this medication. The results indicated that patients on amantadine therapy had lower urinary levels of epinephrine plus norepinephrine than either normal individuals or parkinsonian patients not receiving amantadine. Patients who developed livedo reticularis during amantadine therapy showed a small but significant increase in urinary dopamine levels and a similar decrease in dopac levels, when compared to other patients on amantadine who did not develop livedo reticularis

Optimization of Process Parameters Influencing Biogas Production from Rumen and municipal waste: Analytical Approach

 Rumen waste with high carbohydrate, protein, and lipid content is considered as a suitable substrate for fermentation for methane gas. In this study, direct substrate and co-digestion of rumen waste (RW) and municipal waste (MW) were used. Samples (fresh cow rumen and food waste) were dried, grinded, and blended with water into a semi-solid to facilitate digestion. Central composite design (CCD) was applied to optimize parameters of co-digestion of RW and MW at a different temperature (29 – 33oC), initial pH values, agitation time (AGT), and carbon-nitrogen ratio (C/N). A comparative analysis was done using RSM in a predictive model of the experimental data obtained in accordance with the CCD. The combined effects of temperature, pH, AGT, and C/N as methane production by fermentation of RW and MW were investigated. Optimization using RSM showed a good fit between the experimental and the predicted data as elucidated by the coefficient of determination with R2 values of 0.9214. Quadratic RSM predicted the maximum yield to be 7764 mL CH4/g volatile solid (VS) at optimal conditions of 31°C; pH 7.05; 6s and C/N ratio 20.33. The maximum methane yield was 8550 mL CH4/g VS, at the optimal conditions for the experimental response obtained. The verification experiment successfully produced 8550 mL CH4/g VS within 30 days of incubation. This experiment indicated that the developed model was successfully and can be used for methane production from animal and municipal waste

Calculation of Densities of States and Spectral Functions by Chebyshev Recursion and Maximum Entropy

We present an efficient algorithm for calculating spectral properties of large sparse Hamiltonian matrices such as densities of states and spectral functions. The combination of Chebyshev recursion and maximum entropy achieves high energy resolution without significant roundoff error, machine precision or numerical instability limitations. If controlled statistical or systematic errors are acceptable, cpu and memory requirements scale linearly in the number of states. The inference of spectral properties from moments is much better conditioned for Chebyshev moments than for power moments. We adapt concepts from the kernel polynomial approximation, a linear Chebyshev approximation with optimized Gibbs damping, to control the accuracy of Fourier integrals of positive non-analytic functions. We compare the performance of kernel polynomial and maximum entropy algorithms for an electronic structure example.Comment: 8 pages RevTex, 3 postscript figure

LP 133-373: A New Chromospherically Active Eclipsing dMe Binary with a Distant, Cool White Dwarf Companion

We report the discovery of the partially eclipsing binary LP 133-373. Nearly identical eclipses along with observed photometric colors and spectroscopy indicate that it is a pair of chromospherically active dM4 stars in a circular 1.6 day orbit. Light and velocity curve modeling to our differential photometry and velocity data show that each star has a mass and radius of 0.340+/-0.014 Msolar and 0.33+/-0.02 Rsolar. The binary is itself part of a common proper motion pair with LP 133-374, a cool DC or possible DA white dwarf with a mass of 0.49-0.82 Msolar, which would make the system at least 3 Gyr ol

Cardiac output during cardiopulmonary resuscitation at various compression rates and durations

Cardiac output during cardiopulmonary resuscitation (CPR) was measured by a modified indicator-dilution technique in 20 anesthetized dogs (6-12 kg) during repeated 1- to 2-min episodes of electrically induced ventricular fibrillation and CPR, produced by a mechanical chest compressor and ventilator. With compression rates from 20 to 140/min and compression durations (duty cycles) from 10 to 90% of cycle time, cardiac output (CO) was predicted by the equation: , where CR is compression rate, DC is duty cycle, SVmax (19 ml) is the effective capacity of the pumping chamber, and kl (0.00207 min) and k2 (0.00707 min) are ejection and filling constants. This expression predicts maximal CO for DC = 0.40 and CR = 126/min as well as 90-100% of maximal CO for 0.3 \u3c DC \u3c 0.5 and 70 \u3c CR \u3c 150/min. Such mathematical analysis may prove useful in the optimization of CPR

Electric field gradients in s-, p- and d-metal diborides and the effect of pressure on the band structure and Tc_c in MgB2_2

Results of FLMTO-GGA (full-potential linear muffin-tin orbital -- generalized gradient approximation) calculations of the band structure and boron electric field gradients (EFG) for the new medium-T$_c$ superconductor (MTSC), MgB$_2$, and related diborides MB$_2$, M=Be, Al, Sc, Ti, V, Cr, Mo and Ta are reported. The boron EFG variations are found to be related to specific features of their band structure and particularly to the M-B hybridization. The strong charge anisotropy at the B site in MgB$_2$ is completely defined by the valence electrons - a property which sets MgB$_2$ apart from other diborides. The boron EFG in MgB$_2$ is weakly dependent of applied pressure: the B p electron anisotropy increases with pressure, but it is partly compensated by the increase of core charge assymetry. The concentration of holes in bonding $\sigma$ bands is found to decrease slightly from 0.067 to 0.062 holes/B under a pressure of 10 GPa. Despite a small decrease of N(E$_F$), the Hopfield parameter increases with pressure and we believe that the main reason for the reduction under pressure of the superconducting transition temperature, T$_c$, is the strong pressure dependence of phonon frequencies, which is sufficient to compensate the electronic effects.Comment: 12 pages, 3 figure

Polaron band formation in the Holstein model

We present numerical exact results for the polaronic band structure of the Holstein molecular crystal model in one and two dimensions. The use of direct Lanczos diagonalization technique, preserving the full dynamics and quantum nature of phonons, allows us to analyze in detail the renormalization of both quasiparticle bandwidth and dispersion by the electron-phonon interaction. For the two-dimensional case some of our exact data are compared with the results obtained in the framework of a recently developed finite cluster strong-coupling perturbation theory.Comment: 10 pages (LaTeX), 6 figures (ps), submitted to Phys. Rev.

Institutional Model of Decentralization in Action

Applying the Institutional Model of Decentralization, the paper argues that the presumption that local democracy will impose accountability pressure on elected officials does not always hold. Even in a democratic system like in Indonesia, decentralization policy is welfare-enhancing only for the developed regions, not for all, exacerbating interregional welfare disparity. This "captured democracy" is largely due to the presence of "negative local capture". Where welfare has not improved, limited participation, low initial welfare combined with poor quality of local leaders are found to be the most critical determinants