A preliminary review of the uses of chlorpromazine in psychiatric diseases

Amongst the recent advances in psychiatric treatmentby means of drugs, chlorpromazine is playing an ever increasing and important role. It was first used clinically by Laborit and Hugenard in 1951 in relation to anaesthetics and' later (1953) by ,Delay and Denikerl in psychiatry. It has been adopted generally for virtually every known psychiatric illness and varying opinions have been expressed concerning its efficacy. At the Oranje Hospital it has been in active use for the past 8 months with varying-sometimes startling-results. It has been tried alone or in combination with other drugs or electroconvulsive therapy (etc.)

A bifibrational reconstruction of Lawvere's presheaf hyperdoctrine

Combining insights from the study of type refinement systems and of monoidal closed chiralities, we show how to reconstruct Lawvere's hyperdoctrine of presheaves using a full and faithful embedding into a monoidal closed bifibration living now over the compact closed category of small categories and distributors. Besides revealing dualities which are not immediately apparent in the traditional presentation of the presheaf hyperdoctrine, this reconstruction leads us to an axiomatic treatment of directed equality predicates (modelled by hom presheaves), realizing a vision initially set out by Lawvere (1970). It also leads to a simple calculus of string diagrams (representing presheaves) that is highly reminiscent of C. S. Peirce's existential graphs for predicate logic, refining an earlier interpretation of existential graphs in terms of Boolean hyperdoctrines by Brady and Trimble. Finally, we illustrate how this work extends to a bifibrational setting a number of fundamental ideas of linear logic.Comment: Identical to the final version of the paper as appears in proceedings of LICS 2016, formatted for on-screen readin

The molecular structure of isocyanic acid from microwave and infra-red absorption spectra

Experimental investigations of the infra-red and microwave spectra of the slightly asymmetric rotor, HNCO, have been made, and the structure of the molecule has been determined

Behavioural clusters and predictors of performance during recovery from stroke

We examined the patterns and variability of recovery post-stroke in multiple behavioral domains. A large cohort of first time stroke patients with heterogeneous lesions was studied prospectively and longitudinally at 1-2 weeks, 3 months and one year post-injury with structural MRI to measure lesion anatomy and in-depth neuropsychological assessment. Impairment was described at all timepoints by a few clusters of correlated deficits. The time course and magnitude of recovery was similar across domains, with change scores largely proportional to the initial deficit and most recovery occurring within the first three months. Damage to specific white matter tracts produced poorer recovery over several domains: attention and superior longitudinal fasciculus II/III, language and posterior arcuate fasciculus, motor and corticospinal tract. Finally, after accounting for the severity of the initial deficit, language and visual memory recovery/outcome was worse with lower education, while the occurrence of multiple deficits negatively impacted attention recovery

Teachers of Substance: Subject Matter Knowledge for Teaching

In this paper they are put forward, in the first place, a overview of the reasons why, in the american context, teacher education must share the responsability for the transmission of subject matter knowledge to prospective teachers. They move to a discussion of the research that has been done in this area, getting into focus in your research program about “Growth of Knowledge in Teaching”. Finally, they explore four prominent dimensions of the knowledge for the teaching: subject matter knowledge, substantive knowledge, syntactic knowledge, and beliefs about subject matter

Zero bias anomaly out of equilibrium

The non-equilibrium zero bias anomaly (ZBA) in the tunneling density of states of a diffusive metallic film is studied. An effective action describing virtual fluctuations out-of-equilibrium is derived. The singular behavior of the equilibrium ZBA is smoothed out by real processes of inelastic scattering.Comment: 4 page

Structural Disconnections Explain Brain Network Dysfunction after Stroke

Stroke causes focal brain lesions that disrupt functional connectivity (FC), a measure of activity synchronization, throughout distributed brain networks. It is often assumed that FC disruptions reflect damage to specific cortical regions. However, an alternative explanation is that they reflect the structural disconnection (SDC) of white matter pathways. Here, we compare these explanations using data from 114 stroke patients. Across multiple analyses, we find that SDC measures outperform focal damage measures, including damage to putative critical cortical regions, for explaining FC disruptions associated with stroke. We also identify a core mode of structure-function covariation that links the severity of interhemispheric SDCs to widespread FC disruptions across patients and that correlates with deficits in multiple behavioral domains. We conclude that a lesion\u27s impact on the structural connectome is what determines its impact on FC and that interhemispheric SDCs may play a particularly important role in mediating FC disruptions after stroke