Chemical components and antioxidant activities of methanol extract of Syzygium polycephalum Miq. stem bark (Myrtaceae)

This study aimed to reveal chemical components and screen antioxidant activity of methanolic extract of Syzygium polycephalum stem bark. The chemical components were isolated by using column chromatographic techniques and determined by spectroscopic methods (UV-Vis, FTIR, MS, and NMR) and comparison with literature data, in which the antioxidant activity was performed using 2,2’-diphenyl-1-picrylhydrazyl (DPPH). The present investigation resulted in four compounds involving gallic acid, pinostrobin, 3,4,3’-tri-O-methylellagic acid, and 3,3’-di-O-methylellagic acid. The four compounds were all in the form of phenolic compounds found from the extract whereas 3,4,3’-tri-O-methylellagic acid and 3,3’-di-O-methylellagic acid were ellagic acid derivatives. The methanolic extract, the four compounds, and vitamin C (as positive control) showed antioxidant activity against DPPH with the IC50 value of 99.9; 10.0; 183.2; 72.1; 63.3; and 13.9 µg/mL, respectively. The antioxidant activity of gallic acid was more active than that of vitamin C. The present study confirms that Syzygium polycephalumis rich in phenolic compounds and natural antioxidants

Chemical components and antioxidant activities of methanol extract of Syzygium polycephalum Miq. stem bark (Myrtaceae)

127-136This study aimed to reveal chemical components and screen antioxidant activity of methanolic extract of Syzygium polycephalum stem bark. The chemical components were isolated by using column chromatographic techniques and determined by spectroscopic methods (UV-Vis, FTIR, MS, and NMR) and comparison with literature data, in which the antioxidant activity was performed using 2,2’-diphenyl-1-picrylhydrazyl (DPPH). The present investigation resulted in four compounds involving gallic acid, pinostrobin, 3,4,3’-tri-O-methylellagic acid, and 3,3’-di-O-methylellagic acid. The four compounds were all in the form of phenolic compounds found from the extract whereas 3,4,3’-tri-O-methylellagic acid and 3,3’-di-O-methylellagic acid were ellagic acid derivatives. The methanolic extract, the four compounds, and vitamin C (as positive control) showed antioxidant activity against DPPH with the IC50 value of 99.9; 10.0; 183.2; 72.1; 63.3; and 13.9 µg/mL, respectively. The antioxidant activity of gallic acid was more active than that of vitamin C. The present study confirms that Syzygium polycephalumis rich in phenolic compounds and natural antioxidants

Phenolic Compounds Isolated from The Fern Chingia sakayensis (Zeiller) Holtt

Four known phenolic compounds namely kaemferol, matteucinol, farrerol, and matteucinol-7-O-β-D-glucoside were isolated for the first time from the fern Chingia sakayensis (Zeiller) Holtt’s. All substances were separated by chromatographic techniques, purified by recrystalization, elucidated on the basis of spectroscopic evidence and by comparation with those reported data in literature. These results were very important to study the phytochemicals of the other fern in Chingia genus based on the chemotaxonomic approach

Aktivitas Antioksidan Senyawa yang berasal dari Kayu Artocarpus heterophyllus

Isoprenoid-substituted flavonoids were isolated from the wood of Artocarpus heterophyllus bybiologically activity-guided fractionation, namely antioxidant. The isolated compounds are cudraflavoneC, kuwanon C, norartocarpin, albanin A and artocarpanone have more hydroxyl groups seem to bespecifically to scavenge H2O2. These experimental results demonstrated that each scavenging compounddifferent in its scavenge capacity toward different form of radicals.Beberapa senyawa flavonoid yang mengandung isoprenoid telah diisolasi dari kayu tanamanArtocarpus heterophyllus melalui fraksinasi yang dipandu oleh aktifitas antioksidan. Senyawa-senyawaseperti cudraflavone C, kuwanon C, norartocarpin, albanin A dan artocarpanone memiliki gugushidroksil yang lebih banyak dan terlihat sangat spesifik dalam menangkap H2O2. Hasil-hasil penelitianini menunjukkan bahwa terdapat perbedaan kapasitas aktifitas antiosidannya terhadap sumber radikalbebasnya

Ekstrak Heksana Kulit Satang Tumbuhan Pacar Cina (Aglaia odorata Lour) (Meliaceae)

ABSTRACT A long chain alcohol, 1-eicosanol together with two sterols, {3-sitosteroland stigmasterol had been isolated from hexane extract of stem bark of pacar cina (Aglaia odorata Lour) (Meliaceae). These structures had been established based on spectroscopic data (lR and NMR) and by comparisonto those of standard compounds. Keywords: Aglaia odorata Lour. Alcohol, Meliaceae, Stero

Neuropeptide Yのイヌ冠動脈に対する作用: 摘出血管標本による検討

取得学位 : 博士（医学）, 学位授与番号 : 医博乙第1111号, 学位授与年月日：平成2年12月19日,学位授与年：199

AN ESTER OF 4-METHOXY CYNNAMIC ACID ISOLATED FROM <i>Xylocarpus moluccencis</i> (Lamk) M. Roem (MELIACEAE)

An ester derivative of 4-methoxycynnamic acid, i.e. 2-ethylhexyl 4-methoxy cynnamate was isolated for the first time from the chloroform extract of stem bark of Xylocarpus moluccencis (Lamk) M. Roem) (Meliaceae) along with β-sitosterol and stigmasterol. The first structure was elucidated with the help of various spectroscopic techniques, including IR, GC-MS, and NMR spectra. Two last structures were determined by comparison with the reported compounds in literature. These compounds were also found in the hexane extract of the plant

The Effect of Eucalyptol on Nursing Home Residents

Cognitive impairments such as dementia are common in later life, and have been suggested to occur via a range of mechanisms, including oxidative stress, age-related changes to cellular metabolism, and a loss of phospholipids (PLs) from neuronal membranes. PLs are a class of amphipathic lipids that form plasma membrane lipid bilayers, and that occur at high concentrations in neuronal membranes. Our previous study suggested that a porcine liver decomposition product (PLDP) produced via protease treatment may improve cognitive function at older ages, by acting as a rich source of PLs and lysophospholipids (LPLs); however, its specific composition remains unclear. Thus, the present study used a novel liquid chromatography electrospray ionization tandem mass spectrometric (LC-MS/MS) protocol to identify the major PLs and LPLs in PLDP. Furthermore, it assessed the effect of identified LPLs on microglial activation in vitro, including cell shape, proliferation, and cell morphology. The results of the conducted analyses showed that PLDP and PLDP-derived LPLs concentration-dependently modulate microglial activation in vitro. In particular, lysophosphatidylcholine (LPC) concentration-dependently promotes cell morphology, likely via effects mediated by the enzyme autotaxin (ATX), since inhibiting ATX also promoted cell morphology, while conversely, increasing ATX production (via treatment with high levels of LPC) abolished this effect. These findings suggest that LPC is likely neuroprotective, and thus, support the importance of further research to assess its use as a therapeutic target to treat age-related cognitive impairments, including dementia