Near-Infrared and Visible Photoactivation to Uncage Carbon Monoxide from an Aqueous-Soluble PhotoCORM.

Multiphoton excitation allows one to access high energy excited states and perform valuable tasks in biological systems using tissue penetrating near-infrared (NIR) light. Here, we describe new photoactive manganese tricarbonyl complexes incorporating the ligand 4'-p-N,N-bis(2-hydroxyethyl)amino-benzyl-2,2':6',2″-terpyridine (TPYOH), which can serve as an antenna for two photon NIR excitation. Solutions of Mn(CO)3(TPYOH)X (X = Br- or CF3SO3-) complexes are very photoactive toward CO release under visible light excitation (405 nm, 451 nm). The same responses were also triggered by multiphoton excitation at 750 and 800 nm. In this context, we discuss the potential applications of these complexes as visible/NIR light photoactivated carbon monoxide releasing moieties (photoCORMs). We also report the isolation and crystal structures of the TPYOH complexes Mn(TPYOH)Cl2 and [Mn(TPYOH)2](CF3SO3)2, to illustrate a possible photolysis product(s)

Tris[tris­(1,10-phenanthroline-κ2 N,N′)iron(II)] dodeca­tungstoferrate dihydrate

The title compound, [Fe(C12H8N2)3]3[FeW12O40]·2H2O, was prepared under hydro­thermal conditions. The discrete Keggin-type [FeW12O40]6− heteropolyoxoanion has threefold symmetry, with the FeII atom located on the threefold rotation axis. The central FeO4 tetra­hedron in the anion shares its O atoms with four W3O13 trinuclear units, each of which is made up of three edge-shared WO6 octa­hedral units. The FeII atom in the complex cation, viz [Fe(phen)3]2+ (phen is 1,10-phen­anthroline), shows a slightly distorted octa­hedral geometry defined by six N atoms from three phen ligands. The polyoxoanions pack together with the cations, with the disordered water mol­ecules located in voids; the site occupancy factor for each water O atom is 0.33

Influence of acupuncture on cognitive function and markers of oxidative DNA damage in patients with vascular dementia

AbstractObjectiveTo test the influence of acupuncture on cognitive function and a marker of oxidative DNA damage in patients with vascular dementia (VD).MethodsSixteen VD patients were evaluated before and after acupuncture, using the Folstein Mini-Mental State Examination-Revised (MMSE-R) to assess cognitive function, and the ADL-R scale to assess independence in activities of daily living (ADL). Life quality was evaluated using the DEMQOL (Dementia quality of life questionnaire) questionnaire, and syndromes and expression of vascular dementia were evaluated with the Scale for the Differentiation of Syndromes of Vascular Dementia (SDSVD). In addition, the urine concentration of 8-hydroxy-2′-deoxyguanosine (8-OHdG) —a marker of oxidative damage—was quantified with enzyme-linked immunosorbent assay.ResultsThe MMSE-R and DEMQOL scores were higher after acupuncture than before (P<0.05), while there were no obvious differences in the ADL-R or SDSVD scores (P>0.05). The 8-OHdG content in urine significantly decreased after acupuncture (P<0.05).ConclusionAcupuncture reduces the levels of 8-OHdG and improves cognitive function and quality of life in VD patients, suggesting that acupuncture is beneficial at least in part by preventing oxidative damage

2-(1-Methyl­ethoxy)-5-nitro­phenyl N-methyl­carbamate

In the title compound, C11H14N2O5, the nitro group is approximately coplanar with the benzene ring, making a dihedral angle of 4.26 (17)°. The dihedral angle between the methyl­carbamate group and the benzene ring is 72.47 (6)°. There is a strong inter­molecular N—H⋯O hydrogen bond between the N and O atoms from adjacent methyl­carbamate groups, forming a one-dimensional network along the a axis