2,179 research outputs found
X-Ray Diffraction and structural studies of Cu(II) complex with Gliclazide(N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide),and its hypoglycemic activity
Synthesis and characterization by spectroscopic, X-ray and hypoglycemic activity study of copper complex with gliclazide (N-(hexahydrocyclopenta[c]-pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide) an oral antidiabetic drugs. The conductometric titration using monovariation method indicate that complex are non-ionic and L2M (2:1) type. Analytical data agree with the molecular formula (C15H20N3O3S)2Cu. of complex for gliclazide. The structure of complex was assigned square planner supported by IR, 1H-NMR, X-Ray, mass studies and propose structure (I) for complex.Alloxan induced model have been used to compare hypoglycemic activity of gliclazide complex. Keywords: Gliclazide, Oral antidiabetic drugs, Complexes, IR, NMR. X-Ray, Hypoglycemic activity
Making Maps Available for Play: Analyzing the Design of Game Cartography Interfaces.
Maps in video games have grown into complex interactive systems alongside video games themselves. What
map systems have done and currently do have not been cataloged or evaluated. We trace the history of
game map interfaces from their paper-based inspiration to their current smart phone-like appearance. Read-
only map interfaces enable players to consume maps, which is sufficient for wayfinding. Game cartography
interfaces enable players to persistently modify maps, expanding the range of activity to support planning and
coordination. We employ thematic analysis on game cartography interfaces, contributing a near-exhaustive
catalog of games featuring such interfaces, a set of properties to describe and design such interfaces, a
collection of play activities that relate to cartography, and a framework to identify what properties promote
the activities. We expect that designers will find the contributions enable them to promote desired play
experiences through game map interface design
SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus
10.1371/journal.pone.0019436PLoS ONE65
Simulation of the Magnetothermal Instability
In many magnetized, dilute astrophysical plasmas, thermal conduction occurs
almost exclusively parallel to magnetic field lines. In this case, the usual
stability criterion for convective stability, the Schwarzschild criterion,
which depends on entropy gradients, is modified. In the magnetized long mean
free path regime, instability occurs for small wavenumbers when (dP/dz)(dln
T/dz) > 0, which we refer to as the Balbus criterion. We refer to the
convective-type instability that results as the magnetothermal instability
(MTI). We use the equations of MHD with anisotropic electron heat conduction to
numerically simulate the linear growth and nonlinear saturation of the MTI in
plane-parallel atmospheres that are unstable according to the Balbus criterion.
The linear growth rates measured from the simulations are in excellent
agreement with the weak field dispersion relation. The addition of isotropic
conduction, e.g. radiation, or strong magnetic fields can damp the growth of
the MTI and affect the nonlinear regime. The instability saturates when the
atmosphere becomes isothermal as the source of free energy is exhausted. By
maintaining a fixed temperature difference between the top and bottom
boundaries of the simulation domain, sustained convective turbulence can be
driven. MTI-stable layers introduced by isotropic conduction are used to
prevent the formation of unresolved, thermal boundary layers. We find that the
largest component of the time-averaged heat flux is due to advective motions as
opposed to the actual thermal conduction itself. Finally, we explore the
implications of this instability for a variety of astrophysical systems, such
as neutron stars, the hot intracluster medium of galaxy clusters, and the
structure of radiatively inefficient accretion flows.Comment: Accepted for publication in Astrophysics and Space Science as
proceedings of the 6th High Energy Density Laboratory Astrophysics (HEDLA)
Conferenc
Exact analytical expression for magnetoresistance using quantum groups
We obtain an exact analytical expression for magnetoresistance using
noncommutative geometry and quantum groups.Then we will show that there is a
deep relationship between magnetoresistance and the quantum group ,
from which we understand the quantum interpretation of the quantum corrections
to the conductivity.Comment: 8 pages, 3 figures, replaced with the version published in Physics
Letters
Diversity of human lip prints: a collaborative study of ethnically distinct world populations
Background: Cheiloscopy is a comparatively recent counterpart to the long established dactyloscopic studies. Ethnic variability of these lip groove patterns has not yet been explored. Aim: This study was a collaborative effort aimed at establishing cheiloscopic variations amongst modern human populations from four geographically and culturally far removed nations: India, Saudi Arabia, Spain and Nigeria. Subjects and methods: Lip prints from a total of 754 subjects were collected and each was divided into four equal quadrants. The patterns were classified into six regular types (A?F), while some patterns which could not be fitted into the regular ones were segregated into G groups (G-0, G-1, G-2). Furthermore, co-dominance of more than one pattern type in a single quadrant forced us to identify the combination (COM, G-COM) patterns. Results and conclusion: The remarkable feature noted after compilation of the data included pattern C (a bifurcate/branched prototype extending the entire height of the lip) being a frequent feature of the lips of all the populations studied, save for the Nigerian population in which it was completely absent and which showed a tendency for pattern A (a vertical linear groove) and a significantly higher susceptibility for combination (COM) patterns. Chi-square test and correspondence analysis applied to the frequency of patterns appearing in the defined topographical areas indicated a significant variation for the populations studied
Gravitational Charged Perfect Fluid Collapse in Friedmann Universe Models
This paper is devoted to study the gravitational charged perfect fluid
collapse in the Friedmann universe models with cosmological constant. For this
purpose, we assume that the electromagnetic field is so weak that it does not
introduce any distortion into the geometry of the spacetime. The results
obtained from the junction conditions between the Friedmann and the
Reissner-Nordstrm de-Sitter spacetimes are used to solve the field
equations. Further, the singularity structure and mass effects of the
collapsing system on time difference between the formation of apparent horizons
and singularity have been studied. This analysis provides the validity of
Cosmic Censorship Hypothesis. It is found that the electric field affects the
area of apparent horizons and their time of formation.Comment: 17 pages, accepted for publication in Astrophys. Space Sc
An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma
The incidence of human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is increasing and implicated in more than 60% of all oropharyngeal carcinomas (OPSCCs). Although whole-genome, transcriptome, and proteome analyses have identified altered signaling pathways in HPV-induced HNSCCs, additional tools are needed to investigate the unique pathobiology of OPSCC. Herein, bioinformatics analyses of human HPV(+) HNSCCs revealed that all tumors express full-length E6 and identified molecular subtypes based on relative E6 and E7 expression levels. To recapitulate the levels, stoichiometric ratios, and anatomic location of E6/E7 expression, we generated a genetically engineered mouse model whereby balanced expression of E6/E7 is directed to the oropharyngeal epithelium. The addition of a mutant PIK3CAE545K allele leads to the rapid development of pre-malignant lesions marked by immune cell accumulation, and a subset of these lesions progress to OPSCC. This mouse provides a faithful immunocompetent model for testing treatments and investigating mechanisms of immunosuppression
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