The Effect of two Different Doses of Propofol Infusion on Cardiovascular Responses in Patients Candidate for Nasal Septoplastic Surgery

Background & aim: There is no general consensus on the minimum dose of propofol for maintenance of anesthesia. The purpose of this study was to determine the effect(s) of two different doses of propofol on cardiovascular responses in patients undergoing Septoplasty surgery. Methods: In the present clinical-trial study, fifty-eight patients (15 to 55 years) candidate for nasal Septoplasty were randomly divided into two groups of A (propofol infusion dose 50µg/kg/min) and B (propofol infusion dose 100µg/kg/min). After induction of anesthesia and intubation, propofol infusion was started with two different doses. Systolic, diastolic and mean arterial blood pressures were measured at 0, 2, 5, 10, 15, 20, 30, 45 and 60 minutes after initiation of infusion. The depth of anesthesia during the surgery and wake-up time was evaluated. The data were analyzed by independent sample t-test, Mann-Whitney U test, repeated measure and Freidman. Results: Wake up time in group A and B was (28.71±3.19) and (31.00±5.29) min respectively which no significant differences were observed between the two groups. Changes in heart rate and systolic blood pressure, diastolic and mean arterial at different minutes in each group compared with the other two groups showed no significant difference (p> 0.05). Conclusions: Increasing dose of propofol from 50µ/kg/min to 100µ/kg/min does not affect the depth of anesthesia, cardiovascular responses and wake up time, so a lower dose of propofol infusions is recommended during general anesthesia

Comparing the Incidence of Pulmonary Edema in Anesthesia (with or without use of morphine and lasix) in Children Undergoing PDA Surgery

Abstract: Introduction: Patent ductus arteriosus (PDA) is a congenital cardiovascular disorder found in patients of all ages, from tiny premature infants to older adults (1). Persistent patent ducts arteriosus often cause hemodynamic and respiratory disorders, which require use of inotropic drugs and respiratory support in the full term infants.. Surgical ligation should be considered for patients when medical therapy fails (2). The aim of this study was two anesthesia techniques evaluation for pulmonary edemas reduce in PDA surgery . Methods and Materials: In this study, 120 patients underwent PDA surgery, Patients were divided into two groups of 60, the patients in first group received morphine and lasix during anesthesia but second group received nothing. Results: The average age of the patients in the case and control groups was 32.8 and 31.36 months. Frequency of Male and female in case and control groups was 38.3%, 61.7% and 45%, 55%, respectively. In control group, from 60 patients, 18.3% had pulmonary edema and 5% of them had loss of consciousness. There was significant difference between case and control groups about patients with pulmonary edema. Also, RR (0.001), Pao2 (p=0.005), PH (p=0.01) and PR (P= 0.003) had significant difference in cases and controls. Conclusion: The findings of this study suggest that the use of morphine and Lasix is useful for reduction of pulmonary edema after PDA surgery. Further studies are needed to find the better management method