7,006 research outputs found
Current fluctuations near to the 2D superconductor-insulator quantum critical point
Systems near to quantum critical points show universal scaling in their
response functions. We consider whether this scaling is reflected in their
fluctuations; namely in current-noise. Naive scaling predicts low-temperature
Johnson noise crossing over to noise power at strong
electric fields. We study this crossover in the metallic state at the 2d z=1
superconductor/insulator quantum critical point. Using a Boltzmann-Langevin
approach within a 1/N-expansion, we show that the current noise obeys a scaling
form with . We recover
Johnson noise in thermal equilibrium and at strong
electric fields. The suppression from free carrier shot noise is due to strong
correlations at the critical point. We discuss its interpretation in terms of a
diverging carrier charge or as out-of-equilibrium Johnson
noise with effective temperature .Comment: 5 page
Coulomb screening in mesoscopic noise: a kinetic approach
Coulomb screening, together with degeneracy, is characteristic of the
metallic electron gas. While there is little trace of its effects in transport
and noise in the bulk, at mesoscopic scales the electronic fluctuations start
to show appreciable Coulomb correlations. Within a strictly standard Boltzmann
and Fermi-liquid framework, we analyze these phenomena and their relation to
the mesoscopic fluctuation-dissipation theorem, which we prove. We identify two
distinct screening mechanisms for mesoscopic fluctuations. One is the
self-consistent response of the contact potential in a non-uniform system. The
other couples to scattering, and is an exclusively non-equilibrium process.
Contact-potential effects renormalize all thermal fluctuations, at all scales.
Collisional effects are relatively short-ranged and modify non-equilibrium
noise. We discuss ways to detect these differences experimentally.Comment: Source: REVTEX. 16 pp.; 7 Postscript figs. Accepted for publication
in J. Phys.: Cond. Ma
High-field noise in metallic diffusive conductors
We analyze high-field current fluctuations in degenerate conductors by
mapping the electronic Fermi-liquid correlations at equilibrium to their
semiclassical non-equilibrium form. Our resulting Boltzmann description is
applicable to diffusive mesoscopic wires. We derive a non-equilibrium
connection between thermal fluctuations of the current and resistive
dissipation. In the weak-field limit this is the canonical fluctuation-
dissipation theorem. Away from equilibrium, the connection enables explicit
calculation of the excess ``hot-electron'' contribution to the thermal
spectrum. We show that excess thermal noise is strongly inhibited by Pauli
exclusion. This behaviour is generic to the semiclassical metallic regime.Comment: 13 pp, one fig. Companion paper to cond-mat/9911251. Final version,
to appear in J. Phys.: Cond. Ma
Thalamic deep brain stimulation may relieve breathlessness in COPD
The cerebral mechanisms of dyspnoea (breathlessness) are not well understood. Neuroimaging studies of experimentally induced dyspnoea in healthy individuals have identified several cortical areas that might form a neural network for perception of dyspnoea [1], much like those identified for pain perception [2]. However, functional imaging studies alone do not reveal neurophysiological pathways and may miss putative targets for dyspnoea relief. The objective of this study was to assess the effects of Deep Brain Stimulation (DBS) of four different brain nuclei on the sensation of dyspnoea in an individual with Chronic Obstructive Pulmonary Disease (COPD) using an established multidimensional dyspnoea tool [3]
Late effects of cancer in children, teenagers and young adults: Population-based study on the burden of 183 conditions, in-patient and critical care admissions and years of life lost
Background: Children, teenagers and young adults who survived cancer are prone to developing late effects. The burden of late effects across a large number of conditions, in-patient hospitalisation and critical care admissions have not been described using a population-based dataset. We aim to systematically quantify the cumulative burden of late effects across all cancer subtypes, treatment modalities and chemotherapy drug classes. // Methods: We employed primary care records linked to hospitals, the death registry and cancer registry from 1998–2020. CTYA survivors were 25 years or younger at the time of cancer diagnosis had survived ≥5 years post-diagnosis. Year-of-birth and sex-matched community controls were used for comparison. We considered nine treatment types, nine chemotherapy classes and 183 physical and mental health late effects. Cumulative burden was estimated using mean cumulative count, which considers recurring events. Multivariable logistic regression was used to investigate the association between treatment exposures and late effects. Excess years of life lost (YLL) attributable to late effects were estimated. // Findings: Among 4,063 patients diagnosed with cancer, 3,466 survived ≥ 5 years (85%); 13,517 matched controls were identified. The cumulative burden of late effects at age 35 was the highest in survivors of leukaemia (23.52 per individual [95% CI:19.85–29.33]) and lowest in survivors of germ cell tumours (CI:6.04 [5.32–6.91]). In controls, the cumulative burden was 3.99 (CI:3.93–4.08) at age 35 years. When survivors reach age 45, the cumulative burden for immunological conditions and infections was the highest (3.27 [CI:3.01–3.58]), followed by cardiovascular conditions (3.08 [CI:1.98–3.29]). Survivors who received chemotherapy and radiotherapy had the highest disease burden compared to those who received surgery only. These patients also had the highest burden of hospitalisation (by age 45: 10.43 [CI:8.27–11.95]). Survivors who received antimetabolite chemotherapy had the highest disease and hospitalisation burden, while the lowest burden is observed in those receiving antitumour antibiotics. Regression analyses revealed that survivors who received only surgery had lower odds of developing cardiovascular (adjusted odds ratio 0.73 [CI:0.56–0.94]), haematological (aOR 0.51 [CI:0.37–0.70]), immunology and infection (aOR 0.84 [CI:0.71–0.99]) and renal (aOR 0.51 [CI:0.39–0.66]) late effects. By contrast, the opposite trend was observed in survivors who received chemo-radiotherapy. High antimetabolite chemotherapy cumulative dose was associated with increased risks of subsequent cancer (aOR 2.32 [CI:1.06–4.84]), metastatic cancer (aOR 4.44 [CI:1.29–11.66]) and renal (aOR 3.48 [CI:1.36–7.86]) conditions. Patients who received radiation dose of ≥50 Gy experienced higher risks of developing metastatic cancer (aOR 5.51 [CI:2.21–11.86]), cancer (aOR 3.77 [CI:2.22–6.34]), haematological (aOR 3.43 [CI:1.54–6.83]) and neurological (aOR 3.24 [CI:1.78–5.66]) conditions. Similar trends were observed in survivors who received more than three teletherapy fields. Cumulative burden analyses on 183 conditions separately revealed varying dominance of different late effects across cancer types, socioeconomic deprivation and treatment modalities. Late effects are associated with excess YLL (i.e., the difference in YLL between survivors with or without late effects), which was the most pronounced among survivors with haematological comorbidities. // Interpretation: To our knowledge, this is the first study to dissect and quantify the importance of late morbidities on subsequent survival using linked electronic health records from multiple settings. The burden of late effects is heterogeneous, as is the risk of premature mortality associated with late effects. We provide an extensive knowledgebase to help inform treatment decisions at the point of diagnosis, future interventional trials and late-effects screening centred on the holistic needs of this vulnerable population
Constrained Analysis of Topologically Massive Gravity
We quantize the Einstein gravity in the formalism of weak gravitational
fields by using the constrained Hamiltonian method. Special emphasis is given
to the 2+1 spacetime dimensional case where a (topological) Chern-Simons term
is added to the Lagrangian.Comment: 15 pages, IF-UFRJ-21/9
Counterflow dielectrophoresis for trypanosome enrichment and detection in blood
Human African trypanosomiasis or sleeping sickness is a deadly disease endemic in sub-Saharan Africa, caused by single-celled protozoan parasites. Although it has been targeted for elimination by 2020, this will only be realized if diagnosis can be improved to enable identification and treatment of afflicted patients. Existing techniques of detection are restricted by their limited field-applicability, sensitivity and capacity for automation. Microfluidic-based technologies offer the potential for highly sensitive automated devices that could achieve detection at the lowest levels of parasitemia and consequently help in the elimination programme. In this work we implement an electrokinetic technique for the separation of trypanosomes from both mouse and human blood. This technique utilises differences in polarisability between the blood cells and trypanosomes to achieve separation through opposed bi-directional movement (cell counterflow). We combine this enrichment technique with an automated image analysis detection algorithm, negating the need for a human operator
The Merging of a Coronal Dimming and the Southern Polar Coronal Hole
We report on the merging between the southern polar coronal hole and an adjacent coronal dimming induced by a coronal mass ejection on 2022 March 18, resulting in the merged region persisting for at least 72 hr. We use remote sensing data from multiple co-observing spacecraft to understand the physical processes during this merging event. The evolution of the merger is examined using Extreme-UltraViolet (EUV) images obtained from the Atmospheric Imaging Assembly on board the Solar Dynamic Observatory and Extreme Ultraviolet Imager, which is on board the Solar Orbiter spacecraft. The plasma dynamics are quantified using spectroscopic data obtained from the EUV Imaging Spectrometer on board Hinode. The photospheric magnetograms from the Helioseismic and Magnetic Imager are used to derive the magnetic field properties. To our knowledge, this work is the first spectroscopical analysis of the merging of two open-field structures. We find that the coronal hole and the coronal dimming become indistinguishable after the merging. The upflow speeds inside the coronal dimming become more similar to that of a coronal hole, with a mixture of plasma upflows and downflows observable after the merging. The brightening of the bright points and the appearance of coronal jets inside the merged region further imply ongoing reconnection processes. We propose that component reconnection between the coronal hole and coronal dimming fields plays an important role during this merging event because the footpoint switching resulting from the reconnection allows the coronal dimming to intrude onto the boundary of the southern polar coronal hole
Mapping 6D N = 1 supergravities to F-theory
We develop a systematic framework for realizing general anomaly-free chiral
6D supergravity theories in F-theory. We focus on 6D (1, 0) models with one
tensor multiplet whose gauge group is a product of simple factors (modulo a
finite abelian group) with matter in arbitrary representations. Such theories
can be decomposed into blocks associated with the simple factors in the gauge
group; each block depends only on the group factor and the matter charged under
it. All 6D chiral supergravity models can be constructed by gluing such blocks
together in accordance with constraints from anomalies. Associating a geometric
structure to each block gives a dictionary for translating a supergravity model
into a set of topological data for an F-theory construction. We construct the
dictionary of F-theory divisors explicitly for some simple gauge group factors
and associated matter representations. Using these building blocks we analyze a
variety of models. We identify some 6D supergravity models which do not map to
integral F-theory divisors, possibly indicating quantum inconsistency of these
6D theories.Comment: 37 pages, no figures; v2: references added, minor typos corrected;
v3: minor corrections to DOF counting in section
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