9 research outputs found
How Do User Groups Cope with Delay in Real-Time Collaborative Note Taking
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
International audienceA property of general interest of real-time collaborative editors is delay. Delays exist between the execution of one user's modification and the visibility of this modification to the other users. Such delays are in part fundamental to the network, as well as arising from the consistency maintenance algorithms and underlying architecture of collaborative editors. Existing quantitative research on collaborative document editing does not examine either concern for delay or the efficacy of compensatory strategies. We studied an artificial note taking task in French where we introduced simulated delay. We found out a general effect of delay on performance related to the ability to manage redundancy and errors across the document. We interpret this finding as a compromised ability to maintain awareness of team member activity, and a reversion to independent work. Measures of common ground in accompanying chat indicate that groups with less experienced team members attempt to compensate for the effect of delay. In contrast, more experienced groups do not adjust their communication in response to delay, and their performance remains sensitive to the delay manipulation
Biogeographical patterns and speciation of the genus Pinguicula (Lentibulariaceae) inferred by phylogenetic analyses
- Author
- A Fleischmann
- A Slack
- A Stamatakis
- BE Juniper
- BG Hall
- BJ Whitfield
- C Darwin
- CD Bell
- CI Ortega-Rosas
- CW Birky
- D Bryant
- DE Soltis
- DH Huson
- EJP Douzery
- F Conti
- F Tammaro
- FE Lloyd
- FT Ledig
- G Blanca
- G Turesson
- GV Degtjareva
- H Luhrs
- H Shimai
- H Shimai
- HL Mason
- HT Imai
- I Schubert
- J Contandriopoulos
- J Mallet
- J Mallet
- J Shaw
- JF Smith
- JH Barnhart
- JL Revell
- K Kondo
- K Müller
- K Tamura
- KM Neubig
- L Legendre
- M Cheek
- M Mangy
- M Sun
- N Nomura
- O Hidalgo
- PS Soltis
- PS Soltis
- PS Soltis
- R Lanfear
- R Zamora
- R Zamora
- RD Piperno
- Royal Horticultural Society
- RW Jobson
- S Fior
- S Lozano-García
- S Zamudio
- S Zamudio
- S Zamudio
- S Zamudio
- S Zamudio
- S Zamudio
- S Zamudio
- S Zamudio
- S Zamudio
- S Zamudio
- S Zamudio
- SE Metcalfe
- SG Beck
- SJ Casper
- SJ Casper
- SJ Casper
- SJ Casper
- SJ Casper
- SJ Casper
- ST Malcomber
- T Alm
- T Cieslak
- T Yamanaka
- TJ Givnish
- TJ White
- W Pennington
- Y Heslop-Harrison
- Y Heslop-Harrison
- Y Mitsui
- Y Okuyama
- Z-L Nie
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2021
- Field of study
Earlier phylogenetic studies in the genus Pinguicua (Lentibulariaceae) suggested that the species within a geographical region was rather monophyletic, although the sampling was limited or was restricted to specific regions. Those results conflicted with the floral morphology-based classification, which has been widely accepted to date. In the current study, one nuclear ribosomal DNA (internal transcribed spacer; ITS) and two regions of chloroplast DNA (matK and rpl32-trnL), from up to ca. 80% of the taxa in the genus Pinguicula, covering all three subgenera, were sequenced to demonstrate the inconsistency and explore a possible evolutionary history of the genus. Some incongruence was observed between nuclear and chloroplast topologies and the results from each of the three DNA analyses conflicted with the morphology-based subgeneric divisions. Both the ITS tree and network, however, corresponded with the biogeographical patterns of the genus supported by life-forms (winter rosette or hibernaculum formation) and basic chromosome numbers (haploidy). The dormant strategy evolved in a specific geographical region is a phylogenetic constraint and a synapomorphic characteristic within a lineage. Therefore, the results denied the idea that the Mexican group, morphologically divided into the three subgenera, independently acquired winter rosette formations. Topological incongruence among the trees or reticulations, indicated by parallel edges in phylogenetic networks, implied that some taxa originated by introgressive hybridisation. Although there are exceptions, species within the same geographical region arose from a common ancestor. Therefore, the classification by the floral characteristics is rather unreliable. The results obtained from this study suggest that evolution within the genus Pinguicula has involved; 1) ancient expansions to geographical regions with gene flow and subsequent vicariance with genetic drift, 2) acquirement of a common dormant strategy within a specific lineage to adapt a local climate (i.e., synapomorphic characteristic), 3) recent speciation in a short time span linked to introgressive hybridisation or multiplying the ploidy level (i.e., divergence), and 4) parallel evolution in floral traits among lineages found in different geographical regions (i.e., convergence). As such, the floral morphology masks and obscures the phylogenetic relationships among species in the genus
Cognitive Dysfunction and Depression May Decrease Activities in Daily Life More Strongly Than Pain in Community-Dwelling Elderly Adults Living With Persistent Pain
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Chemical Composition and Antifungal Activity of Essential Oils and Supercritical CO2 Extracts of Apium nodiflorum (L.) Lag.
- Author
- A Maxia
- A Pérez-Parra
- AC Tavares
- Alessandra Piras
- Andrea Maxia
- Bruno Marongiu
- C Cavaleiro
- CA Pereira
- Carlos Cavaleiro
- Council of Europe
- Célia Cabral
- D Joulain
- D Vidic
- Danilo Falconieri
- DG Ferris
- E Pinto
- EB Fuente
- EP Lichtenstein
- EP Lichtenstein
- F Bakkali
- F Lentini
- F Tammaro
- G-D Zhou
- H Laouer
- H Zhang
- I Telci
- JE Simmon
- JL Ríos
- JW Bennett
- L Menghini
- LR Salgueiro
- Lígia Salgueiro
- M Fragiska
- M Ito
- M Razzaghi-Abyaneh
- M Zuzarte
- M Zuzarte
- Maria Assunta Frau
- Maria J. Gonçalves
- PM Guarrera
- R Robert
- RA Calderone
- RP Adams
- SG Knees
- Silvia Porcedda
- SS Tomar
- VV Semenov
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain
- Author
- A Fabiato
- A Klein
- A Medeiros-Domingo
- A Peralvarez-Marin
- A Tammaro
- BA Adams
- BA Block
- CC Tung
- CF Perez
- DC Sheridan
- E Rios
- EF Gillard
- F Noboru
- F Protasi
- F Van Petegem
- F Van Petegem
- F Zorzato
- FJ Amador
- FJ Amador
- G Avila
- G Kugler
- H Edelhoch
- H Jungbluth
- H Tae
- H Takekura
- H Takeshima
- H Tateishi
- HS Tae
- HS Tae
- J Bohm
- J Nakai
- J Nakai
- J Nakai
- J Nakai
- JE Nettleship
- K Otsu
- L Kimlicka
- L Kimlicka
- L Kimlicka
- M Endo
- M Mahalingam
- M Samso
- M Samso
- P Emsley
- P Leong
- P Sharma
- PA Lobo
- PA Lobo
- PD Adams
- R Robinson
- R Wang
- SG Gonsalves
- SG Priori
- SJ Ludtke
- SJ Ludtke
- T Tanabe
- T Tanabe
- TC Terwilliger
- W Kabsch
- W Wriggers
- X Zhong
- Y Cui
- Y Hakamata
- Y Tang
- Z Liu
- Z Yuchi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Functional modulation of voltage-dependent sodium channel expression by wild type and mutated C121W-β1 subunit
- Author
- A Escayg
- A Radonić
- AL Goldin
- AL Goldin
- ALJ George
- AV Vega
- BW Kimes
- C Egri
- C Quan
- CF Ratcliffe
- CM Armstrong
- Cristiana Picco
- D Baroni
- Debora Baroni
- DJ Messner
- DP McEwen
- DS Ragsdale
- FH Yu
- FH Yu
- G Cota
- GA Patiño
- GSB Andavan
- H Watanabe
- J Hescheler
- J Srinivasan
- J Tan
- JC Mulley
- JD Malhotra
- JD Malhotra
- JH Zar
- JM Dubinsky
- K Kazarinova-Noyes
- KA McCormick
- KA McCormick
- KR Sipido
- L Ferrera
- L Meadows
- LL Isom
- LL Isom
- LL Isom
- LL Isom
- LS Meadows
- MH Meisler
- MR Hanlon
- N Qin
- O Hamill
- O Moran
- O Moran
- O Moran
- OH Lowry
- Oscar Moran
- P Tammaro
- R Barbieri
- R Wallace
- R Xu
- Raffaella Barbieri
- RH Wallace
- RP Hartshorne
- S Bacchetti
- S Rozen
- SE Heron
- SG Kaufmann
- SJ Watkins
- T Horikoshi
- T Tseng
- TH Davis
- TK Aman
- VC Wimmer
- W Ulbricht
- WA Catterall
- WJ Brackenbury
- Y Lu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Novel regulators of RyR Ca2+ release channels: insight into molecular changes in genetically-linked myopathies
- Author
- A Buj-Bello
- A Ferreiro
- A Futatsugi
- A Mankodi
- A Nucci
- A Shtifman
- A Tammaro
- A-MB Brillantes
- A. F. Dulhunty
- AA Anderson
- AF Dulhunty
- AF Dulhunty
- AR Marks
- AV Philips
- AV Postma
- B Xiao
- C Strang
- CA Sewry
- CP Moore
- D Balshaw
- D Green
- D Jiang
- D Sandona
- D Terentyev
- DH Kim
- DH MacLennan
- DL Minor
- DR Laver
- E Gouadon
- EM Gallant
- EM Gallant
- EM Gallant
- F Ango
- F Protasi
- F Zorzato
- G Avila
- G Avila
- G Avila
- G Meissner
- GB Gurrola
- GD Lamb
- GD Lamb
- GG Du
- GG Rodney
- GP Ahern
- GP Ahern
- H Jiang
- H Lahat
- HA Fozzard
- I Gyorke
- I Marty
- J Tong
- JC Tu
- JH Westhoff
- JM Gulbis
- JR Mickelson
- K Jurkat-Rott
- K Otsu
- K Paul-Pletzer
- L Gao
- L Machuca-Tzili
- L Zhang
- M Brini
- M Brini
- M Fill
- M Richter
- M Salanova
- M Samso
- M Yano
- MB Bhat
- MM Soloviev
- N Ikemoto
- N Monnier
- N Sergeant
- N Zerangue
- N. A. Beard
- NA Beard
- NA Beard
- NA Beard
- NH Shomer
- P. Pouliquin
- PJ Laitinen
- PJ Laitinen
- PJ Lynch
- R El-Hayek
- R Grunwald
- R Stewart
- RG Weiss
- RS Savkur
- RT Dirksen
- RT Dirksen
- S Ducreux
- S Ducreux
- S Guis
- S Kobayashi
- S Treves
- S Viatchenko-Karpinski
- SG Priori
- SY Hwang
- T Jayaraman
- T Kimura
- T Oda
- T Ohta
- T Yamamoto
- T Yamamoto
- T. Kimura
- TD Houle
- W Cheng
- W Feng
- XH Wehrens
- YM Kobayashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Outcomes from elective colorectal cancer surgery during the SARS‐CoV‐2 pandemic
- Author
- 6\u11f\ufcc\ufc H
- 6fner D
- 6hlberger L
- \u106oza I
- \uc2ngelo M
- \uc4lg\ue5 A
- \uc7elebi F
- \uc7olak E
- Aawsaj Y
- Abad Gurumeta A
- Abad\u2010Motos A
- Abate E
- Abbott D
- Abdalla M
- Abdeldayem H
- Abdelkader Salama I
- Abdelkarim M
- Abdur\u2010Rahman L
- Abel MK
- Aboelkassem Ibrahim A
- Abou Chaar MK
- Abou Chaar Mohamad K.
- Abreu da Silva A
- Abubakar A
- Acebes Garc\ueda F
- Achalandabaso Boira M
- Acher A
- Acrich E
- Adamina M
- Adamina Michel
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adiamah A
- Afonso J
- Agapov M
- Agarwal Arnav
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agresta F
- Aguado H
- Aguilar Gonzalez M
- Aguilera Lorena Maria
- Ahmed Z
- Ahmeidat A
- Ahn JH
- Aiken T
- Aim\ue9 A
- Akalin M
- Akaydin E
- Akhtar MA
- Akhter Rahman MM
- Akin E
- Al Abdallah M
- Al Awwad S
- Al Habes H
- Al Maadany FS
- AL Sayed M
- Al\u2010Habsi R
- Al\u2010Khayal K
- Al\u2010Masri M
- Al\u2010Mohammad A
- Al\u2010Najjar H
- Alaa S
- AlAamer O
- Aladeojebi A
- Alakaloko Felix
- Alam F
- Alameer Ehab
- Alawneh F
- Albertsmeier M
- Albertsmeiers Markus
- Alcaide Matas F
- Alderson Derek
- Aldokali N
- Aleksi\u107 L
- Alemanno G
- Alfieri S
- Alghamdi M
- Alhamed A
- Alharthi M
- Alhassan N
- Ali Adil AK
- Ali M
- Ali S
- Aliyeva Z
- Aljiffry M
- Alkadeeki G
- Almeida AC
- Almeida JI
- Almeida\u2010Reis R
- Almgla N
- Alnumani T
- Alobeed O
- Alonso de la Fuente N
- Alonso Poza A
- Alonso\u2010Lamberti L
- Alqannas M
- Alselaim N
- Alser Osaid
- Alshaar Muhammad
- Alshahrani M
- Alshammari S
- Alsharif F
- Alshryda Sattar
- Altintoprak F
- Alurralde C
- Alvarez E
- Alyami M
- Alzamanan M
- Amaral MJ
- Amin Sahid N
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade R
- Angelou D
- Annamalai S
- Annessi V
- Antic A
- Antonakis P
- Antonopoulou MI
- Anula R
- Aprile A
- Aremu M
- Arican C
- Arigoni M
- Arikan AE
- Arkadopoulos N
- Armao T
- Armatura G
- Arminio A
- Arnaud Alexis P
- Arrowsmith L
- Arulanantham A
- Asaad P
- Ashcroft J
- Ashmore C
- Ashoush F
- Askari A
- Asqalan A
- Athanasakis E
- Athanasiou A
- Atherton R
- Attia D
- Avci EK
- Aversano A
- Ayasra F
- Ayasra Faris
- Ayasra Y
- Aydin C
- Ayorinde J
- Aytac E
- Ayub B
- Ayubi A
- Ayyaz M
- Azam M
- Azamat \u130F
- Azevedo C
- Azevedo Jos\ue9
- Azevedo P
- Ba\u10di\u107 G
- Ba\ueda C
- Babar MS
- Baca B
- Badra R
- Baena Sanfeliu E
- Bagraith K
- Baiao JM
- Baig M
- Bail\uf3n M
- Baili E
- Bajomo O
- Baker A
- Baker O
- Bakmaz B
- Balabel M
- Balasubramaniam D
- Baldari L
- Baldi C
- Baldini E
- Bali R
- Balik E
- Ballabio M
- Ballouhey Q
- Baloyiannis I
- Bandara GBKD
- Bandovas JP
- Bankhead\u2010Kendall Brittany K
- Banky B
- Baptista VH
- Barisic G
- Barker D
- Barlow Emma
- Baron RD
- Barrat B
- Barrett J
- Barrios O
- Barry C
- Bartalucci B
- Bartolini I
- Bartolome MA Hernandez
- Basendowah M
- Bashir Y
- Bass GA
- Bates H
- Batistotti P
- Baxevanidou K
- Beamish A
- Beatson K
- Becker R
- Beech N
- Bekheit M
- Belia F
- Bellacci A
- Belli A
- Bello J
- Bellora P
- Belluco C
- Beltr\ue1n de Heredia J
- Belvedere A
- Benavides Buleje JA
- Benkabbou A
- Benson Ruth A
- Benson Ruth A
- Bergamini C
- Bergeat D
- Bernante P
- Bernasconi M
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- Bertolani E
- Beyer K
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- Bezede C
- Bhalla A
- Bhangu A
- Bhangu Aneel
- Bhangu Aneel
- Bhangu Aneel
- Bhangu Aneel
- Bhasin S
- Bhat GA
- Bhat MA
- Bhatti MI
- Bianchini M
- Bianco F
- Bianco F
- Bigelow B
- Bilgin IA
- Bin Nasser A
- Bin Traiki T
- Biondi A
- Bisagni P
- Bisset C
- Blackwell L
- Blanco\u2010Colino R
- Blanco\u2010Colino Ruth
- Blas Laina JL
- Blazquez Martin A
- Bodla AS
- Boeck M
- Boeker C
- Bonci E
- Bond\u2010Smith G
- Bondurri A
- Bong C
- Boni L
- Bonnet S
- Borges F
- Borges N
- Borghi F
- Bork U
- Borroni G
- Bouchagier K
- Bouche PA
- Bouliaris K
- Boulton AJ
- Boutall A
- Boutros M
- Boutros M
- Bowman S
- Boyce R
- Boyd\u2010Carson H
- Bozkurt E
- Bozkurt MA
- Brachini G
- Bradulskis S
- Brar Amanpreet
- Bravo Infante R
- Breen Kerry A
- Bretherton Chris
- Brewer H
- Brito da Silva F
- Brixton G
- Brocklehurst M
- Brown B
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- Brunt A
- Bruscino A
- Bu\u11fra D
- Bueno Ca\uf1ones AD
- Buerba GA
- Burahee A
- Burgan D
- Burke J
- Burke Joshua
- Buta M
- Butt UI
- Bywater Edward
- Cagigal Ortega EP
- Cagigas Fernandez C
- Cai\uf1a Ruiz R
- Caiado A
- Cakmak G
- Calabr\uf2 M
- Calvo Espino P
- Camacho C
- Caminsky NG
- Campagnaro T
- Campbell W
- Canas\u2010Martinez A
- Cano A
- Cano\u2010Valderrama O
- Canonico G
- Canotilho R
- Cantalejo diaz M
- Capelli P
- Capezzuoli L
- Capitan\u2010Morales L
- Capolupo GT
- Caram EL
- Carbone F
- Carcoforo P
- Cardoso N
- Cardoso P
- Carrano FM
- Carrasco Prats M
- Caruana Edward J
- Carvello MM
- Casati M
- Casiraghi T
- Cassinotti E
- Castro Ruiz C
- Cato LD
- Cayetano Paniagua L
- cberr\ufcck L
- Cecire J
- Ceranic M
- Cervellera M
- Cervera I
- Chakrabortee Sohini
- Chan E
- Chan E
- Chand M
- Chand Manish
- Charalabopoulos A
- Chase T
- Chatzikomnitsa P
- Chaudhry Daoud
- Chavarrias N
- Chebaro A
- Chen S
- Chern H
- Chessa A
- Cheung LK
- Chevallay M
- Chia Z
- Chiappini A
- Chiarugi M
- Chiozza M
- Chitul A
- Cholewa H
- Choolani Bhojwani E
- Choudhry A
- Chowdhury A
- Chowdri NA
- Choynowski M
- Christensen Peter
- Christidis P
- Christoforidis D
- Chrysos E
- Chumbinho B
- Chung E
- Cianflocca D
- Cicerchia PM
- Cintas Catena J
- Ciofic E
- Cirillo B
- Cirocchi N
- Claro M
- Clifford R
- Coccolini F
- Cocozza E
- Coffey JC
- Colao Garc\ueda L
- Collera P
- Colletti G
- Colombari RC
- Colombo F
- Confalonieri M
- Connelly TM
- Conti L
- Conti L
- Contis I
- Corbellini C
- Corless K
- Correa Bonito A
- Correia de S\ue1 T
- Correia AM
- Corrigan M
- Cort\ue9s Guiral D
- Corte Real J
- Cosimelli M
- Costa Santos D
- Costa M
- Costa MJMA
- Costanzi A
- Costeira B
- Costigan F
- Cotoia A
- Cotte E
- Coughlin P
- Cox Daniel
- Cozza V
- Creavin B
- Crichton A
- Cristian D
- Cros B
- Crugnale AS
- Cuadrado\u2010Garc\ueda A
- Cukier Moises
- Cullivan O
- Cuming T
- Cunha C
- Cunha MF
- Cunha Miguel F
- Cunha R
- Cunningham RM
- Curl\u2010Roper T
- Cvetkovic A
- D\u2019Aloisio G
- D\u2019Ugo D
- D\u2019Ugo S
- D\u2019Urso A
- D\uedaz P\ue9rez D
- D\uedaz Pe\uf1a P
- D\uedez\u2010Valladares L
- da N\uf3voa Gomes Miguel Sampaio
- Dainius E
- Daliya P
- Daly A
- Danias N
- Daniels IR
- Davidson Giana H
- Davies E
- Davies RJ
- Dawson Brett E
- Day A
- De Andr\ue9s Asenjo B
- De Andres Olabarria U
- De Lacy FB
- De Manzoni Garberini A
- De Miguel Ardevines MDC
- De Nardi P
- De Palma G.D.
- De Simone V
- De Sousa X
- De Toma G
- De Troia A
- De Vincenti R
- Del Campo Mart\uedn M
- Del valle E
- Delgado B\ufardalo L
- Delimpalta C
- Dellaportas D
- Delrio P
- Demir H
- Demirli At\u131c\u131 S
- Demyttenaere S
- Denet C
- Depalma N
- Derksen T
- Desai Anant
- Desio M
- Deus AC
- Devezas V
- Devine M
- Di Bella A
- Di Candido F
- Di Franco G
- Di Giuseppe M
- Di Lauro K
- Di Maria Grimaldi S
- Di Martino C
- Di Martino M
- Di Marzo F
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Di\ue9guez B
- Diamantis A
- Diaz Del Gobbo R
- Diez Alonso M
- Dijan E
- Dikicier E
- Dincer HA
- Dione Parreno\u2010Sacdalanm Marie
- Divya GS
- Dixon J
- Dom\uednguez I
- Domingos JC
- Donati D
- Doyle A
- Drake Thomas M
- Duchalais E
- Dudi\u2010Venkata NN
- Duff S
- Dunne N
- Duque\u2010Mall\ue9n V
- Dur\ue1n Ballesteros M
- Dwidar O
- Dziakova J
- Eardley N
- Earley H
- Eastmond A
- Ebbeh\uf8j AL
- Economopoulou P
- Edward Fitzgerald J
- Edwards John G
- EF Abbott Tom
- Efthimiou M
- Egan R
- Egoroff N
- El Ahmadi B
- El Amrani M
- El Bouazizi Y
- Elawad A
- Elazzazy E
- Eldaly AS
- Elhadi Muhammed
- Elkadi H
- Elliott JA
- Ellojli I
- Elsey E
- Emerson H
- Emile Sameh
- Emiroglu M
- Emmanuel K
- Emslie K
- Erg\ufcn S
- Erol T
- Escartin J
- Escol\ue0 D
- Eskander M
- Eskander P
- Eskinazi D
- Espin\u2010Basany E
- Esposito G
- Essam E
- Estaire G\uf3mez M
- Esteban Agust\ued E
- Etchill E
- Evans C
- Evans J
- Evans Jonathan P
- Evans Jonathan P
- Evans Jonathan P
- Eweda M
- Ezanno A
- Fabbri N
- Fabre I
- Fahey BA
- Fahmawee T
- Fares Bucci A
- Farik Shebani
- Farnesi F
- Farooka MW
- Farre Font R
- Fathi NQ
- Faulkner G
- Faustino A
- Fayed Y
- Federico P
- Feo CF
- Feo CV
- Fern\ue1ndez Camu\uf1as \uc1
- Fern\ue1ndez Pablos FJ
- Fern\ue1ndez M
- Fernandes U
- Fernandes V
- Ferrari M
- Ferrario L
- Ferraz I
- Ferreira Pinto AP
- Ferreira C
- FF Simoes Joana
- FF Simoes Joana
- FF Simoes Joana
- Figueiredo de Barros I
- Findlay L
- Finnegan L
- Fiore M
- Fiore Marco
- Fiori E
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- Sayyed Raza
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- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Aim
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic.
Method
This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data.
Results
From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58–14.06), postoperative SARS-CoV-2 (16.90, 7.86–36.38), male sex (2.46, 1.01–5.93), age >70 years (2.87, 1.32–6.20) and advanced cancer stage (3.43, 1.16–10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%).
Conclusion
Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks
Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.
- Author
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- Titu S
- Tiwari A
- Todorovic M
- Toia F
- Tojal A
- Tolani MA
- Tonini V
- Toogood G
- Tooulias A
- Topczewski TE
- Torales J
- Tormey S
- Torne A
- Torne R
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- Torres Arcos C
- Torres A
- Torretta S
- Townend D
- Townend P
- Townend P
- Townend P
- Townson A
- Trabulsi N
- Travaglio E
- Tribillon E
- Trivic A
- Troncoso Pereira P
- Tropeano FP
- Trout IM
- Trout IM
- Truant S
- Trujillo Diaz J
- Tsai L
- Tsaousis V
- Tsarkov P
- Tsiamalou I
- Tsiaoussis J
- Tsibulak I
- Tsirlis T
- Tsolakidis D
- Tsoulfas G
- Tsoulfas G
- Tucci R
- Tudela M
- Tudisco R
- Tufo A
- Tugmen C
- Tulina I
- Tuncer K
- Turkington R
- Turnage K
- Turnbull A
- Turrado-Rodriguez V
- Turri G
- Tustin H
- Tutoveanu G
- Tuveri M
- Tweedle E
- Tzedakis S
- Tzerbinis H
- Tzovaras G
- Ueberrueck L
- Ugarte-Sierra B
- Uludag SS
- Umair M
- Umar M
- Underwood C
- Uno M
- Uras C
- Uras C
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- Urbieta A
- Usai A
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- Usseglio J
- Utkan NZ
- Uyanik MS
- Uzunoglu FG
- Vaccarella G
- Vahtsevanos K
- Valbuena Jabares V
- Valdes-Hernandez J
- Valente da Costa A
- Valero Soriano M
- Valero R
- Vallance A
- Vallance A
- Valle Rubio A
- Valtzoglou V
- Valverde S
- Van den Eynde J
- Van den Eynde R
- van der Plas W
- Van Duijvendijk P
- Van Heinsbergen M
- Van Houdt W
- van Ramshorst GH
- Van Wyngaard T
- Vanounou T
- Varazzani A
- Vargas L
- Varley I
- Varma M
- Vasljevic J
- Vassiliu P
- Vatansever D
- Vatish J
- Vatish M
- Vaz Pereira R
- Vaz OP
- Vaz S
- Vazquez Fernandez A
- Veiga D
- Velagapudi S
- Velchuru V
- Velickovic D
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- Venetis G
- Venkatesan SG
- Venn M
- Venn ML
- Venskutonis D
- Vera Mansilla C
- Verberne C
- Vergari R
- Vernon L
- Vervoort D
- Vescio G
- Vezakis A
- Vidakovic S
- Videira JF
- Vidya R
- Vidya R
- Vidya R
- Vieira Caroco T
- Vieira Paiva Lopes AC
- Vieira A
- Vieira B
- Vieira B
- Vieira P
- Vignali A
- Vigorita V
- Vijayan D
- Vilatoba M
- Vilendecic Z
- Villalabeitia Ateca I
- Vimalachandran D
- Vimalachandran D
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- Viswambaram P
- Viswanath Y
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- Vollkommer T
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- Warburton H
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- Warren O
- Warren OJ
- Waseem S
- Wasim T
- Watson D
- Watson LJ
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- Weaver H
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- Wedderburn D
- Weitz J
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- Wensley F
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- Westwood E
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- Whelan P
- Whisker L
- Whitehall E
- Whitmore H
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- Wilkin RJW
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- Williams MA
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- Wilson M
- Wimberger P
- Wimmer A
- Winnand P
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- Winter S
- Winter SC
- Wolfer S
- Wong MPK
- Wong S
- Wong WJ
- Woodham A
- Woodun H
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- Xenaki S
- Xu MJ
- Xyda SE
- Xynos E
- Yahaya AS
- Yanez C
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- Yesantharao P
- Yesilyurt D
- Yetkin G
- Yiallourou A
- Yildirim A
- Yildiz A
- Ying Y
- Yip V
- Yordanov S
- Young R
- Yousof EA
- Youssef A
- Youssef M
- Yuksel E
- Yunus MMF
- Yurttas C
- Zacharoulis D
- Zafar SN
- Zafar SN
- Zakai D
- Zakaria AD
- Zakaria R
- Zakaria Z
- Zambelli MF
- Zambon M
- Zamora L
- Zamvar V
- Zani S
- Zanotti S
- Zanus G
- Zapardiel I
- Zarabini AG
- Zatecky J
- Zegarac M
- Zelic M
- Zeller N
- Zengin AK
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zivanovic M
- Zivkovic M
- Zizzo M
- Zografos C
- Zonta S
- Zorrilla Ortuzar J
- Zourntou S
- Zouzoulas D
- Zubaidi A
- Zullo A
- Publication venue
- Br J Surg
- Publication date
- 11/11/2020
- Field of study
BACKGROUND: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. METHODS: This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. RESULTS: Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. CONCLUSION: Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas