A Model of TeV Scale Physics for Neutrino Mass, Dark Matter and Baryon Asymmetry and its Phenomenology

We discuss some details for the model proposed in Ref. \cite{aks-prl}, in which neutrino oscillation, dark matter, and baryon asymmetry of the Universe can be simultaneously explained by the TeV-scale physics without introducing very high mass scales. An exact discrete $Z_2$ symmetry is introduced, under which new particle contents (a real singlet scalar field, a pair of charged singlet scalar fields and TeV-scale right-handed neutrinos) are assigned to have odd quantum number, whereas ordinary gauge fields, quarks and leptons, and two Higgs doublets are even. Tiny neutrino masses are generated at the three loop level due to the exact $Z_2$ symmetry, by which stability of the dark matter candidate is also guaranteed. The extra Higgs doublet is required not only for the tiny neutrino masses but also for successful electroweak baryogenesis. We discuss phenomenological properties of the model, and find that there are successful scenarios in which above three problems are solved simultaneously under the constraint from current experimental data. We then discuss predictions in such scenarios at ongoing and future experiments. It turns out that the model provides discriminative predictions especially in Higgs physics and dark matter physics, so that it is testable in near future.Comment: Version accepted for publication in Physical Review D, 43 pages, 23 figures. Revised Figs.13 and 14, minor errors and typos corrected, added footnote

Neutrino mass, Dark Matter and Baryon Asymmetry via TeV-Scale Physics without Fine-Tuning

We propose an extended version of the standard model, in which neutrino oscillation, dark matter, and baryon asymmetry of the Universe can be simultaneously explained by the TeV-scale physics without assuming unnatural hierarchy among the mass scales. Tiny neutrino masses are generated at the three loop level due to the exact $Z_2$ symmetry, by which stability of the dark matter candidate is guaranteed. The extra Higgs doublet is required not only for the tiny neutrino masses but also for successful electroweak baryogenesis. The model provides discriminative predictions especially in Higgs phenomenology, so that it is testable at current and future collider experiments.Comment: 4 pages including 3 figures; version with revised figure

Anti-Tumor Effect against Human Cancer Xenografts by a Fully Human Monoclonal Antibody to a Variant 8-Epitope of CD44R1 Expressed on Cancer Stem Cells

BACKGROUND: CD44 is a major cellular receptor for hyaluronic acids. The stem structure of CD44 encoded by ten normal exons can be enlarged by ten variant exons (v1-v10) by alternative splicing. We have succeeded in preparing MV5 fully human IgM and its class-switched GV5 IgG monoclonal antibody (mAb) recognizing the extracellular domain of a CD44R1 isoform that contains the inserted region coded by variant (v8, v9 and v10) exons and is expressed on the surface of various human epithelial cancer cells. METHODS AND PRINCIPAL FINDINGS: We demonstrated the growth inhibition of human cancer xenografts by a GV5 IgG mAb reshaped from an MV5 IgM. The epitope recognized by MV5 and GV5 was identified to a v8-coding region by the analysis of mAb binding to various recombinant CD44 proteins by enzyme-linked immunosorbent assay. GV5 showed preferential reactivity against various malignant human cells versus normal human cells assessed by flow cytometry and immunohistological analysis. When ME180 human uterine cervix carcinoma cells were subcutaneously inoculated to athymic mice with GV5, significant inhibition of tumor formation was observed. Furthermore, intraperitoneal injections of GV5markedly inhibited the growth of visible established tumors from HSC-3 human larynx carcinoma cells that had been subcutaneously transplanted one week before the first treatment with GV5. From in vitro experiments, antibody-dependent cellular cytotoxicity and internalization of CD44R1 seemed to be possible mechanisms for in vivo anti-tumor activity by GV5. CONCLUSIONS: CD44R1 is an excellent molecular target for mAb therapy of cancer, possibly superior to molecules targeted by existing therapeutic mAb, such as Trastuzumab and Cetuximab recognizing human epidermal growth factor receptor family

Microbial community ecosystem network model for chemical energy transport

Microorganisms thriving in low-energy ecosystems have evolved diverse strategies to sustain life, including individual-level energy conservation, optimizing energy utilization through interspecies competition, and mutually beneficial interspecies syntrophy. This study introduces a novel community-level strategy to enhance energy efficiency. We employed an oxidation-reduction (redox) reaction network model to capture the intricate metabolic interactions within microbial communities. Our findings highlight the importance of microbial functional diversity in facilitating metabolic handoffs, leading to an improved energy utilization efficiency. Moreover, the mutualistic division of labor and the resulting complexity of redox pathways actively facilitate material cycling, thereby enhancing energy exploitation. These findings provide new insights into the potential of self-organized ecological interactions to develop efficient energy utilization strategies, with significant implications for the functioning and evolution of microbial ecosystems

Analysis of Specific Personal Information Protection Assessment in the Social Security and Tax Number System of Local Governments in Japan

Part 7: Various Aspects of Computer SecurityInternational audienceA law in Japan has been established concerning the My Number system or the use of numbers for identifying specific individuals in administrative procedures in local governments. The law requires local governments to implement the specific personal implementation protection assessment for social security and tax number systems. In this paper, we analyzed the assessment reports of the specific personal information protection assessments conducted by local governments. We did the analysis in two directions: (1) adequacy of risk assessment and measures, and (2) reuse of the assessment report. Our analysis shows that there was a description of assessment on the risk assessment items, but there were many assessment reports with missing assessment on some operations