ASSOCIAÇÃO DE SULFATO DE VINCRISTINA E PROPIONIBACTERIUM ACNES NO TRATAMENTO DE PAPILOMATOSE ORAL CANINA – RELATO DE CASO

The oral papillomatosis is a benign epithelial neoplasm of viral etiology that affects mainly young and immunosuppressed animals, characterized by the development of proliferative masses called papillomas. The therapy of this disease is controversial and there isn’t a highly effective treatment protocol yet. This study aims to report the use of a therapeutic protocol involving vincristine sulfate to immunostimulatory the basis of Propionibacterium acnes and liposaccharides of Escherichia coli in the treatment of oral papillomatosis in a dog. The treatment protocol consisted of weekly administration of vincristine intravenously starting at a dose of 0,025mg/kg; 0.035 mg/kg during the second week; and then 0.05mg/kg. P. acnes has administered at a dose of 1 ml intramuscularly according to the manufacturer's indications (1 ml/10 kg) every 15 days. From the third week, there was the beginning of the involution of papillomas that were gradually receding until complete resolution of the disease in three months. In this case, the using therapy proved effective, since it has provided a cure of the disease. Thus, this therapeutic protocol may be an alternative for cases refractory to usual therapy with Thuya occidentalis