22 research outputs found
In vitro effects of sulfadiazine and its metabolites alone and in combination with pyrimethamine on Toxoplasma gondii.
Get PDFSulfadiazine and the metabolites N4-acetyl-sulfadiazine, 4-OH-sulfadiazine, 5-OH-sulfadiazine, 5-OH-glucuronide-sulfadiazine, and 5-OH-sulfate-sulfadiazine were tested separately and in combination with pyrimethamine for the inhibitory activity on Toxoplasma gondii growth in vitro. Except for N4-acetyl-sulfadiazine, all sulfa compounds possessed anti-Toxoplasma activity. The addition of 0.05 micrograms of pyrimethamine per ml, a concentration which in itself is not inhibitory, potentiated the microbial activity of sulfadiazine and its metabolites 100 fold
Population pharmacokinetics of pyrimethamine and sulfadoxine in children with congenital toxoplasmosis
No full textInfluence of Antimicrobial Agents on Replication and Stage Conversion of Toxoplasma gondii
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Limited value of PCR for detection of Toxoplasma gondii in blood from human immunodeficiency virus-infected patients
No full textIn vitro antagonistic and indifferent activity of combination of 3-deoxyanthocyanidins against Toxoplasma gondii
No full textAssessment of laboratory methods used in the diagnosis of congenital toxoplasmosis after maternal treatment with spiramycin in pregnancy
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