656 research outputs found
Boundary layer models for calving marine outlet glaciers
We consider the flow of marine-terminating outlet glaciers that are laterally
confined in a channel of prescribed width. In that case, the drag exerted by
the channel side walls on a floating ice shelf can reduce extensional stress
at the grounding line. If ice flux through the grounding line increases with
both ice thickness and extensional stress, then a longer shelf can reduce
ice flux by decreasing extensional stress. Consequently, calving has an
effect on flux through the grounding line by regulating the length of the
shelf. In the absence of a shelf, it plays a similar role by controlling the
above-flotation height of the calving cliff. Using two calving laws, one due
to Nick et al. (2010) based on a model for
crevasse propagation due to hydrofracture and the other simply asserting
that calving occurs where the glacier ice becomes afloat, we pose and analyse
a flowline model for a marine-terminating glacier by two methods: direct
numerical solution and matched asymptotic expansions. The latter leads to a
boundary layer formulation that predicts flux through the grounding line as a
function of depth to bedrock, channel width, basal drag coefficient, and a
calving parameter. By contrast with unbuttressed marine ice sheets, we find
that flux can decrease with increasing depth to bedrock at the grounding
line, reversing the usual stability criterion for steady grounding line
location. Stable steady states can then have grounding lines located on
retrograde slopes. We show how this anomalous behaviour relates to the
strength of lateral versus basal drag on the grounded portion of the glacier
and to the specifics of the calving law used
Substance Misuse Education for Physicians: Why Older People are Important.
This perspective article focuses on the need for training and education for undergraduate medical students on substance-related disorders, and describes initiatives undertaken in the United Kingdom (UK), Netherlands, United States (US), and Norway to develop the skills, knowledge, and attitudes needed by future doctors to treat patients adequately. In addition, we stress that in postgraduate training, further steps should be taken to develop Addiction Medicine as a specialized and transverse medical domain. Alcohol use disorder is a growing public health problem in the geriatric population, and one that is likely to continue to increase as the baby boomer generation ages. Prescription drug misuse is a major concern, and nicotine misuse remains problematic in a substantial minority. Thus, Addiction Medicine training should address the problems for this specific population. In recent years, several countries have started an Addiction Medicine specialty. Although addiction psychiatry has been a subspecialty in the UK and US for more than 20 years, in most countries it has been a more recent development. Additional courses on addiction should be integrated into the curriculum at both undergraduate and postgraduate levels, as well as form part of the continuous training of other medical specialists. It is recommended that further research and mapping of what is currently taught in medical programs be undertaken, so as to enhance medical education in addiction and improve treatment services
Healthcare Resource Utilization Among Patients in England with Systemic Sclerosis-Associated Interstitial Lung Disease: A Retrospective Database Analysis
Introduction
Systemic sclerosis-associated interstitial lung disease (SSc-ILD) places a substantial burden on patients and healthcare systems. The objectives of this study were to describe clinical characteristics and assess healthcare resource utilization and costs of patients with SSc-ILD in England, compared with patients with non-pulmonary organ involvement related to SSc (SSc-OOI).
Methods
This population-based retrospective study used data from the Clinical Practice Research Datalink linked to Hospital Episode Statistics. Data were extracted from medical records dated January 1, 2005 to March 31, 2016. Patients with SSc were identified and placed in subgroups based on organ involvement: SSc-ILD, SSc-OOI, and both (SSc-ILD-OOI). Patients with SSc-ILD-OOI were included in both the SSc-ILD and SSc-OOI subgroups. All-cause healthcare costs, excluding medication costs, were calculated to 2016 British pounds sterling (£).
Results
This study included 675 patients with SSc: 174 (26%) had neither ILD nor other organ involvement (OOI); 127 (19%) had SSc-ILD; 477 (71%) had SSc-OOI; 103 (15%) had SSc-ILD-OOI. Age-weighted median [interquartile range (IQR)] annual healthcare costs per patient were: £1496 (£664–£2817) in SSc only; £6375 (£3451–£15,041) in SSc-ILD; £4084 (£1454–£10,105) in SSc-OOI; £6632 (£4023–£17,009) in SSc-ILD-OOI. In multivariate analysis, older age at diagnosis, diagnosis of anemia, and number of comorbid diseases were associated with higher yearly healthcare costs.
Conclusion
The annual healthcare cost for patients with SSc-ILD is substantial, and higher than that of patients with SSc-OOI or SSc only. These results quantify the economic burden of SSc-ILD in a real-world setting, and highlight the need for treatment of this disease
Dynamically and Statistically Downscaled Seasonal Temperature and Precipitation Hindcast Ensembles for the Southeastern USA
We present results from a 15-year 10-member warm season (March–September) hindcast ensemble of maximum and minimum surface air temperatures and precipitation in southeast USA. The hindcasts are derived from the Florida State University/Center for Ocean-Atmospheric Prediction Studies Global Spectral Model (FSU/COAPS GSM) and downscaled using both the FSU/COAPS Nested Regional Spectral Model (NRSM) and a statistical downscaling method based on stochastic weather generator techniques. We additionally consider statistical bias correction of the dynamical model output. Basic descriptive statistics indicate that the bias-corrected and statistically downscaled data reduce the FSU/COAPS GSM bias considerably in terms of basic climatology. Statistics describing the daily precipitation process are improved by both downscaling techniques relative to the bias-corrected GSM. Improvement in monthly and seasonal hindcasts relative to FSU/COAPS GSM is spatially and temporally varying. Precipitation hindcasts are generally less skillful than those for temperature, although useful precipitation predictability exists at many locations. Hindcast improvements due to downscaling are greatest over peninsular Florida. The smallest root mean square errors (RMSE) for temperature hindcasts are found in the southern part of the study region during the spring months of March, April and May (MAM) for maximum surface air temperature, and in the summer, June, July and August (JJA), for minimum surface air temperature. Overall, there is no indication that either downscaling method has a direct advantage over the other
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Development of a common data model for scientific simulations
The problem of sharing data among scientific simulation models is a difficult and persistent one. Computational scientists employ an enormous variety of discrete approximations in modeling physical processes on computers. Problems occur when models based on different representations are required to exchange data with one another, or with some other software package. Within the DOE`s Accelerated Strategic Computing Initiative (ASCI), a cross-disciplinary group called the Data Models and Formats (DMF) group, has been working to develop a common data model. The current model is comprised of several layers of increasing semantic complexity. One of these layers is an abstract model based on set theory and topology called the fiber bundle kernel (FBK). This layer provides the flexibility needed to describe a wide range of mesh-approximated functions as well as other entities. This paper briefly describes the ASCI common data model, its mathematical basis, and ASCI prototype development. These prototypes include an object-oriented data management library developed at Los Alamos called the Common Data Model Library or CDMlib, the Vector Bundle API from the Lawrence Livermore Laboratory, and the DMF API from Sandia National Laboratory
Cubic Curves, Finite Geometry and Cryptography
Some geometry on non-singular cubic curves, mainly over finite fields, is
surveyed. Such a curve has 9,3,1 or 0 points of inflexion, and cubic curves are
classified accordingly. The group structure and the possible numbers of
rational points are also surveyed. A possible strengthening of the security of
elliptic curve cryptography is proposed using a `shared secret' related to the
group law. Cubic curves are also used in a new way to construct sets of points
having various combinatorial and geometric properties that are of particular
interest in finite Desarguesian planes.Comment: This is a version of our article to appear in Acta Applicandae
Mathematicae. In this version, we have corrected a sentence in the third
paragraph. The final publication is available at springerlink.com at
http://www.springerlink.com/content/xh85647871215644
On the shortness of vectors to be found by the Ideal-SVP quantum algorithm
The hardness of finding short vectors in ideals of cyclotomic number fields (hereafter, Ideal-SVP) can serve as a worst-case assumption for numerous efficient cryptosystems, via the average-case problems Ring-SIS and Ring-LWE. For a while, it could be assumed the Ideal-SVP problem was as hard a
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