10 research outputs found
Inventário das espécies de Lepturinae, Parandrinae e Prioninae (Insecta, Coleoptera, Cerambycidae) do Parque Nacional do Itatiaia, RJ, Brasil
Características do adulto, genitália e formas imaturas de Gonipterus gibberus Boisduval e G. scutellatus Gyllenhal (Coleoptera, Curculionidae)
Capacitance-voltage characterization of pulsed plasma polymerized allylamine dielectrics for flexible polymeric field effect transistors
New Data on the Taxonomy of the Weevil Subgenus Caucasoplinthus, Genus Plinthus (Coleoptera, Curculionidae)
Revisão do gênero neotropical Coelosis Hope (Coleoptera, Scarabaeidae, Dynastinae) Revision of the neotropical genus Coelosis Hope (Coleoptera, Scarabaeidae, Dynastinae)
<abstract language="eng">The genus Coelosis with two subgenera, Coelosis s.str. [type species: Scarabaeus sylvanus Fabricius, 1775] and Eucoelosis subgen.n. [type species: Scarabaeus biloba Linnaeus, 1767], is revised and redescribed. Other four species: C. (C.) inermis Sternberg, 1908, C. (C.) bourgini (Dechambre, 1976), C. (Eucoelosis) hippocrates Blanchard, 1846, and C. (E.) bicornis (Leske, 1779) were recognized and redescribed. Coelosis (E.) denticornis Arrow, 1937 was not studied, and the original description is transcribed herein. New characters considered relevant for comparative studies and for species identification are presented. The subgenus Millotsis Bourgin, 1944 [type species: Coelosis inermis Sternberg, 1908] is considered a junior subjective synonym of Coelosis s.str.. A phenetic analysis is presented
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Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease
Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide analyses of participants in the HUNT Study in Norway (n = 69,479) to search for protein-altering variants with beneficial impact on quantitative blood traits related to cardiovascular disease, but without detrimental impact on liver function. We identify 76 (11 previously unreported) presumed causal protein-altering variants associated with one or more CVD- or liver-related blood traits. Nine of the variants are predicted to result in loss-of-function of the protein. This includes ZNF529:p.K405X, which is associated with decreased low-density-lipoprotein (LDL) cholesterol (P = 1.3 × 10−8) without being associated with liver enzymes or non-fasting blood glucose. Silencing of ZNF529 in human hepatoma cells results in upregulation of LDL receptor and increased LDL uptake in the cells. This suggests that inhibition of ZNF529 or its gene product should be prioritized as a novel candidate drug target for treating dyslipidemia and associated CVD. © 2020, The Author(s).Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]