Combined treatment with amphotericin-B and granulocyte transfusion from G-CSF-stimulated donors in an aplastic patient with invasive aspergillosis undergoing bone marrow transplantation.

Granulocyte transfusions from G-CSF stimulated donors were added to standard anti-infective treatment in preparation for and during allogeneic bone marrow transplantation in a young man affected by very severe acute aplastic anemia and invasive aspergillosis. Nine concentrates with a mean neutrophil content of 18.7x109/L (2.6x 108/kg patient b.w.) were transfused before and after marrow infusion. An impressive clinical improvement was noticed after each granulocyte transfusion, although this was not always paralleled by a neutrophil increase in the peripheral blood. Engraftment (N>0.5x109/L and PIt >25x109/L) was verified at +16 and +40 days, respectively. The patient is currently in complete hematological and microbiological remission 14 months after transplantation. Granulocyte apheresis from G-CSF stimulated donors provides a high number of activated neutrophils. At the dose given (300 μg/day) donor tolerance to G-CSF was excellent. This new approach is indicated when life-threatening infections develop in patients exposed to prolonged severe neutropenia

Does quality really matter? Variables that drive postmodern consumer choices

Purpose – The purpose of this paper is to provide insights into the factors that affect consumer choices for both policymakers and food companies. Design/methodology/approach – Four hundred questionnaires were administered in the city of Florence (Tuscany, Italy). Data analysis was carried out according to a two-step procedure in a multivariate statistical framework: in the first stage, a multiple correspondence analysis was performed; in the second step, the single-link (nearest neighbour) cluster analysis allowed three homogeneous groups of consumers to be identified on the basis of their specific socio-demographic characteristics. Findings – Three consumer clusters were obtained: the first, “critical but non-philanthropic consumers”, who may have pathologies that require a particular diet; the second, “marginally critical consumers”, for whom freshness, the label and the assortment count for much; the third, “agnostic consumers”, who choose a product according to its origin and the price/quality relationship, while ethical aspects, health claims or information on the use are not considered as important. Social implications – From the results it may be deduced that although recent regulations will lead to greater transparency, in many respects consumers may not be able to grasp aspects of higher quality from the label among competing products. Originality/value – The results seem to run contrary to the trends identified in other studies with regard to critical and socially responsible production attributes. Except in cases where consumers are sensitised by the presence of food-related diseases encountered within their own family, they may not be able to grasp higher-quality aspects from the label among competing products. From the results it is evident that both educational and generational issues come into play with regard to food choices, closely linked to the media from which information is obtained

Factors Affecting Food Label Complexity: Does the New EU Regulation Satisfy Consumer Issues? An Exploratory Study

There is still a substantial information asymmetry between producers and consumers. Despite the recent EU regulation on labeling to enhance consumer food safety and the existence of a number of certifications on sustainable food products, there remain blind spots in the widely debated consumer information issue. Our study, conducted on primary data processed with a probit model, was aimed at identifying the factors that may affect consumer response in relation to difficulties in interpreting the labels of processed food products. Starting from theoretical models, several factors held responsible for defining the consumer’s knowledge were used as explanatory variables. Our results show that despite changes in the new legislation, there remains the problem of the consumer’s lack of knowledge concerning environmental labeling and product certification