Practical issues in using novel sensors in SHM of civil infrastructure: problems and solutions in implementation of GPS and fibre optic sensors

Author's manuscript of paper presented at the Fourth International Workshop on Structural Health Monitoring, September 15-17, 2003. Deposited with permission of the publisher.Published version of full conference proceedings available for purchase from the publisher via http://www.destechpub.com/index.php?fuseAction=catalogs.viewItem&catalogID=1&catalogLevelID=&catalogItemID=136Proceedings published as: Structural Health Monitoring 2003; From Diagnosis & Prognostics to Structural Health Management; Proceedings of the Fourth International Workshop on Structural Health Monitoring, September 15-17, 2003; Editor: Fu-Kuo Chang, Department of Aeronautics and Astronautics, Stanford University; ISBN13: 978-1-932078-20-6, 1-932078-20-7, September 2003.This article appeared in Structural Health Monitoring 2003—Proceedings of the 4th International Conference Workshop on Structural Health Monitoring, 2003. Lancaster, PA: DEStech Publications, Inc.Two contemporary research programs have explored the use of newer type of sensors believed, and advertised, to have potential in future implementation of SHM system for civil structures. Fibre optic sensors have the possibility to record a range of physical parameters simultaneously and at high speed through multiplexing capabilities of the fibre Bragg grating (FBG); GPS has the advantage to measure absolute displacement of slowly moving flexible structures without need for optical line of sight. FBG sensors have been tested in laboratory situations and have finally been implemented for strain measurements in an expressway viaduct construction program. Meanwhile, a twin-rover GPS system mounted on top of one of Singapore’s tallest buildings has recently provided real-time static and dynamic response data as part of an existing monitoring system designed to study structural performance during wind and earthquake loading. Some of the first results of these two programs will be presented. Both implementations have been problematic in different ways and the paper will identify some of the difficulties and the solutions adopted. The practical limitations and optimal applications can thus be identified

mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells

Evidence from yeast and mammals argues the existence of cross-talk between transcription and mRNA decay. Stabilization of transcripts upon depletion of mRNA decay factors generally leads to no changes in mRNA abundance, attributing this to decreased transcription rates. We show that knockdown of human XRN1, CNOT6 and ETF1 genes in HepG2 cells led to significant alteration in stability of specific mRNAs, alterations in half-life were inversely associated with transcription rates, mostly not resulting in changes in abundance. We demonstrate the existence of the gene expression buffering mechanism in human cells that responds to both transcript stabilization and destabilization to maintain mRNA abundance via altered transcription rates and may involve translation. We propose that this buffering may hold novel cancer therapeutic targets.</p

Polyacrylate grafted graphene oxide nanocomposites for biomedical applications

[[abstract]]Utilizing a reverse micelle process, we have grafted polyacrylate (P) on graphene oxide (GO) to realize polyacrylate grafted graphene oxide (P-GO) nanocomposites, upon whose subsequent reduction, polyacrylate grafted reduced graphene oxide (P-rGO) nanocomposites are achieved. Using techniques such as ultraviolet photoelectron spectroscopy (UPS), x-ray photoelectron spectroscopy, and x-ray absorption near edge structure (XANES) spectroscopy, in conjunction with high-resolution microscopy, Raman spectroscopy, and superconducting quantum interference device analysis, we have studied in depth the electronic, microstructural, electrical, and magnetic properties of these P-GO and P-rGO nanocomposites. While polyacrylate grafting ensures a high solubility of P-GO and P-rGO, the P-rGO nanocomposites additionally show a near doubling of the paramagnetic response (9.6 × 10−3 emu/g) as compared to the r-GO (5.6 × 10−3 emu/g) and P-GO (5.5 × 10−3 emu/g), respectively, at 2 K. The grafting of diamagnetic polyacrylate enhances the magnetic response for the P-GO and P-rGO owing to the increase in the defect states, sp3-type bonding, and enhanced magnetic coupling between the magnetic moments arising due to the presence of nitrogen functionalities. This behavior is further corroborated via the measurements of the electronic structure by XANES and UPS measurements. Thus, the possibility of manipulation of the magnetic behavior along with the abundance of surface functional groups makes both P-GO and P-rGO nanocomposites highly conducive for deriving water-soluble functionalized graphene by linking affinity molecules with polyacrylate backbone for biological and biomedical applications.[[notice]]補正完

Deep Markov Random Field for Image Modeling

Markov Random Fields (MRFs), a formulation widely used in generative image modeling, have long been plagued by the lack of expressive power. This issue is primarily due to the fact that conventional MRFs formulations tend to use simplistic factors to capture local patterns. In this paper, we move beyond such limitations, and propose a novel MRF model that uses fully-connected neurons to express the complex interactions among pixels. Through theoretical analysis, we reveal an inherent connection between this model and recurrent neural networks, and thereon derive an approximated feed-forward network that couples multiple RNNs along opposite directions. This formulation combines the expressive power of deep neural networks and the cyclic dependency structure of MRF in a unified model, bringing the modeling capability to a new level. The feed-forward approximation also allows it to be efficiently learned from data. Experimental results on a variety of low-level vision tasks show notable improvement over state-of-the-arts.Comment: Accepted at ECCV 201

Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations

Dominantly acting loss-of-function mutations in the ABCC8/KCNJ11 genes can cause mild medically responsive hyperinsulinaemic hypoglycaemia (HH). As controversy exists over whether these mutations predispose to diabetes in adulthood we investigated the prevalence of diabetes in families with dominantly inherited ATP-sensitive potassium (K-ATP) channel mutations causing HH in the proband.We studied the phenotype of 30 mutation carriers (14 children and 16 adults) from nine families with dominant ABCC8/KCNJ11 mutations. Functional consequences of six novel missense mutations were examined by reconstituting the K-ATP channel in human embryonic kidney 293 (HEK293) cells and evaluating the effect of drugs and metabolic poisoning on the channels using the Rb-86 flux assay.The mutant channels all showed a lack of Rb-86 efflux on exposure to the channel agonist diazoxide or metabolic inhibition. In the families, dominant ABCC8/KCNJ11 mutations were associated with increased birthweight (median + 1.56 SD score [SDS]). Fourteen children had HH and five adults were reported with HH or hypoglycaemic episodes (63%). Progression from hypoglycaemia to diabetes mellitus occurred in two individuals. Eight adults had a history of gestational diabetes in multiple pregnancies or were diabetic (diagnosed at a median age of 31 years). Within these families, none of the 19 adults who were not carriers of the ABCC8/KCNJ11 mutation was known to be diabetic.The phenotype associated with dominant ABCC8/KCNJ11 mutations ranges from asymptomatic macrosomia to persistent HH in childhood. In adults, it may also be an important cause of dominantly inherited early-onset diabetes mellitus

Access to Oral Health Care: Professional and Societal Considerations

Abstract: Access to health care is a complex subject with vast personal, economic, political, and societal ramifications. Issues concerning the rights and responsibilities of health care professionals-collectively and as individual members of a profession-comprise an important topic within ongoing debates concerning access to care, and constituted the overarching focus of the deliberations that form the basis of this publication. This article provides definitions of key terms; data concerning demography, oral health status, and use of dental services for children and seniors; and a contextual framework for examining broad underlying professional and societal considerations. It concludes with reflections on joint responsibilities and guiding principles that apply to dental professionals and government agencies charged with administering public benefits programs and the consequences likely to ensue if these vital stakeholders fail to respect fundamental principles of professionalism and economics

Does Work Quality Differ between the Public and Private Sectors? Evidence from Two Online Field Experiments

This is the final version. Available on open access from Oxford University Press via the DOI in this recordData Availability Statement: The data and code to reproduce the results reported in this article are available at the Open Science Foundation doi: https://osf.io/8f95q/Understanding the differences between working in the public and private sectors is core to public management research. We assess the implications of a theory of public ownership, testing an expectation that work is of higher quality when performed under public ownership status compared to a private company. We conducted two, pre-registered, field experiments with a routine data processing task and workers recruited through an online labor market. Workers were randomly allocated information about the ownership status of a nursing home as either a public organization or a private company. Work quality was measured as errors workers made in data entry and correcting pre-existing errors in work materials provided to them. The first experiment showed that fewer workers in the public, compared to the private, nursing home tended to make any data entry errors but that they did not correct more existing errors. Exploratory analyses showed a greater effect for those aware of the organization’s ownership status. To test this apparent sector attention effect, we conducted a second experiment with a 2-by-2 factorial design randomly allocating workers to a treatment making salient the public or private sector status of the organization, in addition to the initial public or private sector treatment. The results confirmed the effect of public sector status and sector attention in combination; workers who were assigned to a public sector organization rather than a private company and who were made aware of the respective sector status were more likely to perform their work tasks without any errors. We discuss the limits of the findings and their implications including that public organizations could boost the quality of work done by making their sector status more explicit to workers

Motivated proteins: a web application for studying small three-dimensional protein motifs

&lt;b&gt;BACKGROUND:&lt;/b&gt; Small loop-shaped motifs are common constituents of the three-dimensional structure of proteins. Typically they comprise between three and seven amino acid residues, and are defined by a combination of dihedral angles and hydrogen bonding partners. The most abundant of these are alphabeta-motifs, asx-motifs, asx-turns, beta-bulges, beta-bulge loops, beta-turns, nests, niches, Schellmann loops, ST-motifs, ST-staples and ST-turns.We have constructed a database of such motifs from a range of high-quality protein structures and built a web application as a visual interface to this. &lt;b&gt;DESCRIPTION:&lt;/b&gt; The web application, Motivated Proteins, provides access to these 12 motifs (with 48 sub-categories) in a database of over 400 representative proteins. Queries can be made for specific categories or sub-categories of motif, motifs in the vicinity of ligands, motifs which include part of an enzyme active site, overlapping motifs, or motifs which include a particular amino acid sequence. Individual proteins can be specified, or, where appropriate, motifs for all proteins listed. The results of queries are presented in textual form as an (X)HTML table, and may be saved as parsable plain text or XML. Motifs can be viewed and manipulated either individually or in the context of the protein in the Jmol applet structural viewer. Cartoons of the motifs imposed on a linear representation of protein secondary structure are also provided. Summary information for the motifs is available, as are histograms of amino acid distribution, and graphs of dihedral angles at individual positions in the motifs. &lt;b&gt;CONCLUSION:&lt;/b&gt; Motivated Proteins is a publicly and freely accessible web application that enables protein scientists to study small three-dimensional motifs without requiring knowledge of either Structured Query Language or the underlying database schem