43 research outputs found
Is the Exposome Involved in Brain Disorders through the Serotoninergic System?
Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic monoamine acting as a neurotransmitter in the central nervous system (CNS), local mediator in the gut, and vasoactive agent in the blood. It has been linked to a variety of CNS functions and is implicated in many CNS and psychiatric disorders. The high comorbidity between some neuropathies can be partially understood by the fact that these diseases share a common etiology involving the serotoninergic system. In addition to its well-known functions, serotonin has been shown to be a mitogenic factor for a wide range of normal and tumor cells, including glioma cells, in vitro. The developing CNS of fetus and newborn is particularly susceptible to the deleterious effects of neurotoxic substances in our environment, and perinatal exposure could result in the later development of diseases, a hypothesis known as the developmental origin of health and disease. Some of these substances affect the serotoninergic system and could therefore be the source of a silent pandemic of neurodevelopmental toxicity. This review presents the available data that are contributing to the appreciation of the effects of the exposome on the serotoninergic system and their potential link with brain pathologies (neurodevelopmental, neurodegenerative, neurobehavioral disorders, and glioblastoma)
Etude de l'activite proteine phosphatase endogene de la phosphatase alcaline des membranes plasmiques de foie de rat
SIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : TD 83632 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
Métabolisme énergétique et diététique adaptée au marathonien
POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF
Troubles du sommeil et migraine (physiologie et traitements)
POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF
Maladie de Parkinson (de l'annonce de la maladie à sa prise en charge quotidienne)
POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF
Médicaments potentiellement amnésiants délivrés à l'officine
POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF
Adaptation de l'homme à l'altitude (aspects physiologiques et pathologiques)
POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF
Les céphalées chroniques quotidiennes par abus médicamenteux
POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF
Les bienfaits de l'activité physique (implication des endocannabinoïdes)
POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF
Les troubles du sommeil et leurs traitements
POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF