Patients With Psychoactive Substance Use Disorders Treated In A Psychiatric Emergency Unit

Study type: Prevalence study. Objective: To describe the socio demographic and clinical profile of patients with mental and behavioral disorders due to psychoactive substance (PAS) use, evaluated by the Psychiatric team of the Referenced Emergency Unit (REU) at the State University Clinical Hospital of Campinas (UNICAMP-HC). Methods and casuistic: This is a descriptive and quantitative study, which analyzed patients with mental and behavioral disorders due to PAS use, evaluated by the Psychiatric team of the REU-HC-UNICAMP during a period of 12 months, starting on May 2010. Results: There were evaluated 350 patients with PAS related disorders, representing 23.8% of those who sought psychiatric care. Most were males and younger than other patients of the emergency unit. The main reason for seeking help was psychiatric complaint other than PAS related disorders (23.1%), followed by desire to be treated oneself/being admitted to inpatient psychiatric treatment (20.8%) and intoxication (12.5%); 38.5% had a diagnosis of multiple PAS dependence and 34.8% were diagnosed with isolated alcohol dependence; 36% had psychiatric comorbidities and, when compared to other patients, they received more medications during attendance and were less directed to primary care units. Conclusion: There is a high rate of consultations of patients with PAS related problems in the psychiatric emergency unit. Data on the profile of the evaluated these patients can contribute to the improvement of care to this population.49214315

Impurity effects in quasiparticle spectrum of high-Tc superconductors

The revision is made of Green function methods that describe the dynamics of electronic quasiparticles in disordered superconducting systems with d-wave symmetry of order parameter. Various types of impurity perturbations are analyzed within the simplest T-matrix approximation. The extension of the common selfconsistent T-matrix approximation (SCTMA) to the so-called group expansions in clusters of interacting impurity centers is discussed and hence the validity criteria for SCTMA are established. A special attention is payed to the formation of impurity resonance states and localized states near the characteristic points of energy spectrum, corresponding to nodal points on the Fermi surface

The Ecotoxicity of Pyrimethanil for Aquatic Biota

Via the application of agrochemicals, farmers currently guarantee high productivity of fruit and vegetable crops. However, pest reduction using excessive amounts of such chemicals has a negative effect on aquatic organisms. The spray-drift, leaching, run-off or accidental spills occurring during or after application has become a serious and increasing problem for aquatic ecosystems. Pyrimethanil (PYR) is one of the most used fungicides. Such increase has heightened the interest in studying the potential risk and influence of PYR on the environment. In this chapter information on the PYR environmental risks for aquatic organisms was divided into three different approaches: (i) assessment of toxic effects of the pure active ingredient or the commercial formulation on primary producers, (ii) assessment of toxic effects of the pure active ingredient and PYR formulation on aquatic animals, and (iii) estimation of the role of PYR as an environmental disturber by triggering avoidance response. The available data provide evidences that PYR is potentially toxic for many aquatic species, affecting survival, reproduction, feeding, growth, and that it can disturb the environmental quality with no direct effect at the individual level by inducing organisms to migrate to less impacted areas

Nudging using the ‘dish of the day’ strategy does not work for plant-based meals in a Danish sample of adolescent and older people

© 2018 John Wiley & Sons Ltd Adequate nutrition is an important factor for health and well-being in adolescents and later years. Fruits and vegetables are part of a healthy diet as important source of nutrients, but their intakes are lower than the recommendations in European countries. This study aimed to compare the choices made by adolescents and older people between three similar dishes, one based on meat, one on fish and one on vegetables, in two different conditions: a neutral (control) situation and an intervention situation in which the vegetable-based meal was designated ‘dish of the day’. The comparisons of choices will be made within the same age group (adolescents in the control group vs. adolescents in the intervention group; older people in the control group vs. older people in the intervention group). A quasi-randomised field trial design was used with a sample of 94 adolescents (aged 10–19 years) and 97 older people (aged ≥65 years), who were randomly allocated to intervention or control groups. In the control situation participants were asked to choose between three similar meals, one meat, one fish and one the VeggiEat dish. In the intervention, the VeggiEat dish was labelled the ‘Dish of the day’. All dishes were provided free of charge, displayed side by side in the same order and served in same portions. The dish choices showed no differences between the control and intervention groups in both age groups, and no differences were found among the other variables analysed. This nudging strategy, ‘dish of the day’, seems not to work for the Danish sample of adolescents and older people. Future nudging studies with these populations are needed in order to find the best strategy to move adolescents' and older people's food habits toward a healthier pattern

RAG Recombinase as a Selective Pressure for Genome Evolution

The RAG recombinase is a domesticated transposable element co-opted in jawed vertebrates to drive the process of the so-called V(D)J recombination, which is the hallmark of the adaptive immune system to produce antigen receptors. RAG targets, namely, the Recombination Signal Sequences (RSS), are rather long and degenerated sequences, which highlights the ability of the recombinase to interact with a wide range of target sequences, including outside of antigen receptor loci. The recognition of such cryptic targets by the recombinase threatens genome integrity by promoting aberrant DNA recombination, as observed in lymphoid malignancies. Genomes evolution resulting from RAG acquisition is an ongoing discussion, in particular regarding the counter-selection of sequences resembling the RSS and the modifications of epigenetic regulation at these potential cryptic sites. Here, we describe a new bioinformatics tool to map potential RAG targets in all jawed vertebrates. We show that our REcombination Classifier (REC) outperforms the currently available tool and is suitable for full genomes scans from species other than human and mouse. Using the REC, we document a reduction in density of potential RAG targets at the transcription start sites of genes co-expressed with the rag genes and marked with high levels of the trimethylation of the lysine 4 of the histone 3 (H3K4me3), which correlates with the retention of functional RAG activity after the horizontal transfer.Instituto Gulbenkian de Ciência; Optimus alive award; Fundação para a Ciência e Tecnologia grant: (SFRH/BPD/65292/2009).info:eu-repo/semantics/publishedVersio