Some issues concerning Large-Eddy Simulation of inertial particle dispersion in turbulent bounded flows

The problem of an accurate Eulerian-Lagrangian modeling of inertial particle dispersion in Large Eddy Simulation (LES) of turbulent wall-bounded flows is addressed. We run Direct Numerical Simulation (DNS) for turbulent channel flow at shear Reynolds numbers equal to 150 and 300 and corresponding a-priori and a-posteriori LES on differently coarse grids. We then tracked swarms of different inertia particles and we examined the influence of filtering and of Sub-Grid Scale (SGS) modeling for the fluid phase on particle velocity and concentration statistics. We also focused on how particle preferential segregation is predicted by LES. Results show that even ``well-resolved'' LES is unable to reproduce the physics as demonstrated by DNS, both for particle accumulation at the wall and for particle preferential segregation. Inaccurate prediction is observed for the entire range of particles considered in this study, even when the particle response time is much larger than the flow timescales not resolved in LES. Both a-priori and a-posteriori tests indicate that recovering the level of fluid and particle velocity fluctuations is not enough to have accurate prediction of near-wall accumulation and local segregation. This may suggest that reintroducing the correct amount of higher-order moments of the velocity fluctuations is also a key point for SGS closure models for the particle equation. Another important issue is the presence of possible flow Reynolds number effects on particle dispersion. Our results show that, in small Reynolds number turbulence and in the case of heavy particles, the shear fluid velocity is a suitable scaling parameter to quantify these effects

Statistical properties of an ideal subgrid-scale correction for Lagrangian particle tracking in turbulent channel flow

One issue associated with the use of Large-Eddy Simulation (LES) to investigate the dispersion of small inertial particles in turbulent flows is the accuracy with which particle statistics and concentration can be reproduced. The motion of particles in LES fields may differ significantly from that observed in experiments or direct numerical simulation (DNS) because the force acting on the particles is not accurately estimated, due to the availability of the only filtered fluid velocity, and because errors accumulate in time leading to a progressive divergence of the trajectories. This may lead to different degrees of inaccuracy in the prediction of statistics and concentration. We identify herein an ideal subgrid correction of the a-priori LES fluid velocity seen by the particles in turbulent channel flow. This correction is computed by imposing that the trajectories of individual particles moving in filtered DNS fields exactly coincide with the particle trajectories in a DNS. In this way the errors introduced by filtering into the particle motion equations can be singled out and analyzed separately from those due to the progressive divergence of the trajectories. The subgrid correction term, and therefore the filtering error, is characterized in the present paper in terms of statistical moments. The effects of the particle inertia and of the filter type and width on the properties of the correction term are investigated.Comment: 15 pages,24 figures. Submitted to Journal of Physics: Conference Serie

Coincident onset of multiple sclerosis and herpes simplex virus 1 encephalitis. a case report

Background: Along with vitamin D, smoking, body mass index and others, Epstein Barr virus, other herpesviruses and human endogenous retroviruses represent plausible environmental risk factors for multiple sclerosis. However, it is difficult to obtain direct proof of their involvement in the etiology of this condition. Case presentation: In order to contribute further evidence of the importance of these viruses, and speculate about disease-relevant interactions between these agents and a predisposed genetic background of the host, we describe the temporal association between multiple sclerosis onset and Herpes simplex 1-encephalitis in a female patient. Conclusions: This case illustrates a possible relationship between HSV-1 encephalitis and multiple sclerosis. Bearing in mind that association does not imply causation, some speculations about the etiology and pathophysiology of the two diseases can be made. The hypothesis of a genetic background predisposing to HSV-1 encephalitis and to immune-mediated demyelination is supported by the coincidence of the two conditions in this patient, along with data from animal models and genetic studies

Unsteady flow regimes in arrow-shaped micro-mixers with different tilting angles

Two arrow-shaped micro-mixers, obtained from the classical T-shaped geometry by tilting downward the inlet channels, are considered herein. The two configurations, having different tilting angle values, have been chosen since they show significantly different flow topologies and mixing performances at low Reynolds numbers. In the present paper, we use both experimental flow visualizations and direct numerical simulations to shed light on the mixing behavior of the two configurations for larger Reynolds numbers, for which the mixers present unsteady periodic flows, although in laminar flow conditions. The tilting angle influences the flow dynamics also in the unsteady regimes and has a significant impact on mixing. The configuration characterized by the lower tilting angle, i.e., α = 10°, ensures a better global mixing performance than the one with the larger angle, i.e., α = 20°

Mixing sensitivity to the inclination of the lateral walls in a T-mixer

One of the simplest geometries for micro-mixers has a T-shape, i.e., the two inlets join perpendicularly the mixing channel. The cross-sections of the channels are usually square/rectangular, as straight walls facilitate experimental and modeling analysis. On the contrary, this work investigates through Computational Fluid Dynamics the effect of a cross-section with lateral walls inclined of an angle α as such an inclination may stem from different microfabrication techniques. Considering water as operating fluid, the same mixing performance as square/rectangular cross-sections is obtained for inclinations α≤3°; this indicates the maximum admissible error on the perpendicularity of the walls in the manufacturing process. Above this value, the presence of inclined walls delays the onset of the engulfment regime at higher Reynolds numbers, and for α≥23°the mixing is hampered dramatically, as the flow is unable to break the mirror symmetry and enter in the engulfment regime. At low Reynolds numbers, the mixing is moderately improved for α≥10°, because the vortex regime presents a lower degree of symmetry than that of T-mixers with straight walls

Autoimmune complications in chronic lymphocytic leukemia in the era of targeted drugs

Autoimmune phenomena are frequently observed in patients with chronic lymphocytic leukemia (CLL) and are mainly attributable to underlying dysfunctions of the immune system. Autoimmune cytopenias (AIC) affect 4–7% of patients with CLL and mainly consist of autoimmune hemolytic anemia and immune thrombocytopenia. Although less common, non-hematological autoimmune manifestations have also been reported. Treatment of CLL associated AIC should be primarily directed against the autoimmune phenomenon, and CLL specific therapy should be reserved to refractory cases or patients with additional signs of disease progression. New targeted drugs (ibrutinib, idelalisib and venetoclax) recently entered the therapeutic armamentarium of CLL, showing excellent results in terms of efficacy and became an alternative option to standard chemoimmunotherapy for the management of CLL associated AIC. However, the possible role of these drugs in inducing or exacerbating autoimmune phenomena still needs to be elucidated. In this article, we review currently available data concerning autoimmune phenomena in patients with CLL, particularly focusing on patients treated with ibrutinib, idelalisib, or venetoclax, and we discuss the possible role of these agents in the management of AIC

On the performance of a cointegration-based approach for novelty detection in realistic fatigue crack growth scenarios

Confounding influences, such as operational and environmental variations, represent a limitation to the implementation of Structural Health Monitoring (SHM) systems in real structures, potentially leading to damage misclassifications. In this framework, this study considers cointegration as a state of the art method for data normalisation in fatigue crack propagation scenarios, where monitoring is performed by a distributed network of strain sensors. Specifically, the work is aimed at demonstrating the effectiveness of cointegration on real engineering data in a new context, where the damage is continuously growing. Cointegration is applied at first in a controlled scenario consisting of a numerical strain simulation by means of a finite element model, modified in order to take realistic temperature fluctuations and sensor noise into account. Afterwards, detrending and anomaly detection performances are verified in two different experimental programmes on realistic aeronautical structures subjected to fatigue crack growth, including a full-scale fatigue test on a helicopter tail boom. Strain measurements are taken from a network of Fibre Bragg Grating (FBG) sensors, known to be extremely sensitive to temperature variations, hence delivering challenging scenarios for cointegration testing. Results are shown to be in good agreement with the experimental evidence, with the cointegration algorithm capable of detecting the onset of damage propagation within a 4 mm increment from a baseline condition

Chamber basis of the Orlik-Solomon algebra and Aomoto complex

We introduce a basis of the Orlik-Solomon algebra labeled by chambers, so called chamber basis. We consider structure constants of the Orlik-Solomon algebra with respect to the chamber basis and prove that these structure constants recover D. Cohen's minimal complex from the Aomoto complex.Comment: 16 page