Pion Generalized Parton Distributions within a fully covariant constituent quark model

We extend the investigation of the Generalized Parton Distribution for a charged pion within a fully covariant constituent quark model, in two respects: (i) calculating the tensor distribution and (ii) adding the treatment of the evolution, needed for achieving a meaningful comparison with both the experimental parton distribution and the lattice evaluation of the so-called generalized form factors. Distinct features of our phenomenological covariant quark model are: (i) a 4D Ansatz for the pion Bethe-Salpeter amplitude, to be used in the Mandelstam formula for matrix elements of the relevant current operators, and (ii) only two parameters, namely a quark mass assumed to hold $m_q=~220$ MeV and a free parameter fixed through the value of the pion decay constant. The possibility of increasing the dynamical content of our covariant constituent quark model is briefly discussed in the context of the Nakanishi integral representation of the Bethe-Salpeter amplitude.Comment: Pages 20, figure 11 and table 8. Minor changes. To be published in EPJ

Transcriptomics and metabolomics integration reveals redox-dependent metabolic rewiring in breast cancer cells

Rewiring glucose metabolism toward aerobic glycolysis provides cancer cells with a rapid generation of pyruvate, ATP, and NADH, while pyruvate oxidation to lactate guarantees refueling of oxidized NAD+ to sustain glycolysis. CtPB2, an NADH-dependent transcriptional co-regulator, has been proposed to work as an NADH sensor, linking metabolism to epigenetic transcriptional reprogramming. By integrating metabolomics and transcriptomics in a triple-negative human breast cancer cell line, we show that genetic and pharmacological down-regulation of CtBP2 strongly reduces cell proliferation by modulating the redox balance, nucleotide synthesis, ROS generation, and scavenging. Our data highlight the critical role of NADH in controlling the oncogene-dependent crosstalk between metabolism and the epigenetically mediated transcriptional program that sustains energetic and anabolic demands in cancer cells

[Strain-gauge plethysmography with venous occlusion: update].

Una review metodologica circa la platismografia ad occlusione venosa, una metodiche che consente la misurazione del flusso arterioso segmentale e del deflusso venoso. Tale metodica sar\ue0 ampiamente utilizzata dal prof. Casiglia in un un gran numero di studi sperimentali

[Simultaneous non-invasive evaluation of regional hemodynamic parameters in essential arterial hypertension].

Ampia reviiew metodologica circa la misurazione contemporanea di parametri emodinamici periferici, poi ampiamente usati dal prof. Casiglia in numerose pubblicazioni sperimentali

DIAGNOSIS OF HIGH-GRADE STENOSIS OF INNOMINATE-ARTERY

Abstract Although pathology of the innominate artery (IA) is not frequent, it causes relevant impairment of extracranial circulation and sometimes cerebrovascular events. Definite differentiation of high-grade stenosis from occlusion of the IA has not been obtained until now with continuous-wave (C.W.) Doppler and duplex system ultrasound, and thus the direct evaluation of IA is not reliable by noninvasive methods. In this study the authors suggest an indirect method of evaluation of IA pathology based on the study of carotid, subclavian, and vertebral arteries (VA) with echo-Doppler-color-flow (EDCF) (with linear--phase array probes of 7.5 and 5 MHz). In the last two years they studied 6 patients with IA pathology (2 with occlusion (occ), 1 with stenosis of 80% and 3 with subocclusive stenosis > 90%). In both patients with occ, right VA flow was inverted, and also the right common carotid (CC) was involved (occ in 1 case and inverted flow in the other); in the 3 subocclusive stenoses a lowered systolic flow in the CC was recorded (48 vs 85 cm/sec, 41 vs 77, and 23 vs 109). In the 80% stenosis, besides the inverted flow in VA, only a reduced diastolic flow in CC was also recorded (19 vs 33 cm/sec measured in the left side). All patients with high grade stenosis were successfully confirmed by an angiographic study, including the different degree of stenosis. Five of the 6 patients underwent surgical correction with a restored flow in the previously involved artery. Only 1 patient with occlusion is waiting for surgical correction.(ABSTRACT TRUNCATED AT 250 WORDS