Geography and indigeneity I: Indigeneity, coloniality and knowledge

Why talk of indigeneity rather than of Indigenous peoples? This report examines the critical purchase on questions of inequality, subjectivity and power offered by critical geographies of indigeneity. In comparison with accounts that treat indigeneity as relational with nature and the more-than-human, the report highlights literature that examines indigeneity as relational with deeply historical, institutionalized and power-inflected ontologies. To think about settler colonialism as an ongoing effect, not a singular event, recognizes how patterns of engagement with and oppression of indigeneity pervade the colonial present and its geographies beyond the specific locales associated with Indigenous peoples. Finally, the report examines how indigeneity figures in the geography discipline’s knowledge production, and argues that worldly Indigenous ontologies are theorizing the world precisely because they are forced to apprehend, appraise and then rethink ‘universals’. NoneThis is the author accepted manuscript. The final version is available from SAGE via http://dx.doi.org/10.1177/030913251561295

Geography and indigeneity III: Co-articulation of colonialism and capitalism in indigeneity’s economies

In this final report of three, I examine Indigenous peoples’ dynamic co-constitution with contemporary political economy in its manifestations of neoliberalism, resource extractivism, reordering production and labour relations. Indigenous subjects and spaces are not reducible to the status of capitalism’s side-effects, necessitating analytical attention to the co-articulation of colonialism and capitalism in particular, variegated ways. Debates around extractivism, neoliberalism and economic want are hence recent manifestations of 500-year-old disputes over monetary and normative values, resources and livelihoods. Whether as corporations, labourers, welfare recipients, or ambassadors for culturally distinctive forms of livelihoods-exchange, Indigenous peoples occupy complex, relational positions across economic spheres. The paradox of indigeneity’s economies is that Indigenous populations have been constituted as Other to homo oeconomicus, yet their embeddedness within the economic flows, labour processes and forms of accumulation that make the modern world belie any separation. The report ends by raising questions about decolonising accounts of indigeneity’s economies.</jats:p

The political geographies of D/decolonization: Variegation and decolonial challenges of /in geography

Anglophone and North Atlantic geography is enmeshed institutionally, epistemically and racially in colonial modern privilege, highlighting the urgent task of addressing its modes of theorization, interpretation, and research. Decolonizing analysis builds from postcolonial, critical, feminist and racism critiques, and problematizes accounts of knowledge, subjectivity and power. In pursuit of decolonizing knowledge production and addressing global inequalities, this paper enjoins political geography to more systematically engage with decolonial analysis, conceptualization and theory. Political geography has much to contribute to interdisciplinary decolonial scholarship through contextualized, grounded, multiscalar and granular analysis of socio-spatial relations. The paper examines the common ground and potential tensions between Anglophone political geographies and decolonial theory (῾decoloniality’), then examines the case of Ecuador's politics of plurinationalism to illustrate a decolonizing political geographical analysis. The case highlights how the variegated political geographies of decolonization arising within and against coloniality require from political geography a decolonial turn, which would entail divesting core political geography concepts of western norms, including plural epistemologies of space and power in analysis, and recalibrating knowledge production processes

Geography and indigeneity II: Critical geographies of indigenous bodily politics

In this, the second of three reports on indigeneity in geography, the focus is on the social differentiation within embodiments, subjectivities and social positionings within and across indigenous groups. Indigeneity is a social-corporeal positioning within socially-differentiated fields of power, history and relations with land and earth. As a consequence, geography focuses on temporally- and spatially-specific processes by which embodiments and epistemic positions are produced, expressed and diversified. Also significant are the ongoing relations of power at multiple scales that entail the production of indigenous bodies as the marked outcomes of colonial-modern distributions of harm. Taken together, these analyses suggest that the embodiment of indigeneity arises from colonial-modern mediations of intersectional social hierarchies, resulting in multifaceted patterns of differentiated agency

Development of an in vitro three dimensional loading-measurement system for long bone fixation under multiple loading conditions: a technical description

The purpose of this investigation was to design and verify the capabilities of an in vitro loading-measurement system that mimics in vivo unconstrained three dimensional (3D) relative motion between long bone ends, applies uniform load components over the entire length of a test specimen, and measures 3D relative motion between test segment ends to directly determine test segment construct stiffness free of errors due to potting-fixture-test machine finite stiffness

Sovereign debt management and the globalization of finance: recasting the City of London’s ‘Big Bang’

This article focuses on the central position of sovereign debt securities in the financial system to challenge existing accounts about the 1986 ‘Big Bang’ deregulation of the City of London’s securities market. The reforms are often cast as an iconic moment of neoliberal deregulation and a key episode in the globalization of financial markets. Such accounts stress that the state played an active role in constructing the reforms and upholding the global market relations they produced, yet they remain unclear about the state’s direct interest in pursuing financial market liberalization. The article contends that domestic concerns over sovereign debt management were central to the state’s pursuit of regulatory change. The Big Bang reforms greatly expanded the size and liquidity of the market for British sovereign debt. This empowered the state, improving its capacity to conduct monetary policy and to raise finance on better terms. In doing so, the article demonstrates the necessity of examining sovereign debt management in order to specify the state’s role in the construction of financial globalization

Additive Pressures of Elevated Sea Surface Temperatures and Herbicides on Symbiont-Bearing Foraminifera

Elevated ocean temperatures and agrochemical pollution individually threaten inshore coral reefs, but these pressures are likely to occur simultaneously. Experiments were conducted to evaluate the combined effects of elevated temperature and the photosystem II (PSII) inhibiting herbicide diuron on several types of symbiotic algae (diatom, dinoflagellate or rhodophyte) of benthic foraminifera in hospite. Diuron was shown to evoke a direct effect on photosynthetic efficiency (reduced effective PSII quantum yield ΔF/F′m), while elevated temperatures (>30°C, only 2°C above current average summer temperatures) were observed to impact photosynthesis more indirectly by causing reductions in maximum PSII quantum yield (Fv/Fm), interpreted as photodamage. Additionally, elevated temperatures were shown to cause bleaching through loss of chlorophyll a in foraminifera hosting either diatoms or dinoflagellates. A significant linear correlation was found between reduced Fv/Fm and loss of chlorophyll a. In most cases, symbionts within foraminifera proved more sensitive to thermal stress in the presence of diuron (≥1 µg L−1). The mixture toxicity model of Independent Action (IA) described the combined effects of temperature and diuron on the photosystem of species hosting diatoms or dinoflagellates convincingly and in agreement with probabilistic statistics, so a response additive joint action can be assumed. We thus demonstrate that improving water quality can improve resilience of symbiotic phototrophs to projected increases in ocean temperatures. As IA described the observed combined effects from elevated temperature and diuron stress it may therefore be employed for prediction of untested mixtures and for assessing the efficacy of management measures

Insertion of Vaccinia Virus C7L Host Range Gene into NYVAC-B Genome Potentiates Immune Responses against HIV-1 Antigens

Background: The highly attenuated vaccinia virus strain NYVAC expressing HIV-1 components has been evaluated as a vaccine candidate in preclinical and clinical trials with encouraging results. We have previously described that the presence of C7L in the NYVAC genome prevents the induction of apoptosis and renders the vector capable of replication in human and murine cell lines while maintaining an attenuated phenotype in mice. Methodology/Principal Findings: In an effort to improve the immunogenicity of NYVAC, we have developed a novel poxvirus vector by inserting the VACV host-range C7L gene into the genome of NYVAC-B, a recombinant virus that expresses four HIV-1 antigens from clade B (Env, Gag, Pol and Nef) (referred as NYVAC-B-C7L). In the present study, we have compared the in vitro and in vivo behavior of NYVAC-B and NYVAC-B-C7L. In cultured cells, NYVAC-B-C7L expresses higher levels of heterologous antigen than NYVAC-B as determined by Western blot and fluorescent-activated cell sorting to score Gag expressing cells. In a DNA prime/poxvirus boost approach with BALB/c mice, both recombinants elicited robust, broad and multifunctional antigen-specific T-cell responses to the HIV-1 immunogens expressed from the vectors. However, the use of NYVAC-B-C7L as booster significantly enhanced the magnitude of the T cell responses, and induced a more balanced cellular immune response to the HIV-1 antigens in comparison to that elicited in animals boosted with NYVAC-B. Conclusions/Significance: These findings demonstrate the possibility to enhance the immunogenicity of the highl