On the Adaptive Security of MACs and PRFs

We consider the security of two of the most commonly used cryptographic primitives—message authentication codes (MACs) and pseudorandom functions (PRFs)—in a multi-user setting with adaptive corruption. Whereas is it well known that any secure MAC or PRF is also multi-user secure under adaptive corruption, the trivial reduction induces a security loss that is linear in the number of users. Our main result shows that black-box reductions from “standard” assumptions cannot be used to provide a tight, or even a linear-preserving, security reduction for adaptive multi-user secure deterministic stateless MACs and thus also PRFs. In other words, a security loss that grows with the number of users is necessary for any such black-box reduction

Role of neuroinflammation in neurodegeneration: new insights

Previously, the contribution of peripheral infection to cognitive decline was largely overlooked however, the past 15 years have established a key role for infectious pathogens in the progression of age-related neurodegeneration. It is now accepted that the immune privilege of the brain is not absolute, and that cells of the central nervous system are sensitive to both the inflammatory events occurring in the periphery and to the infiltration of peripheral immune cells. This is particularly relevant for the progression of Alzheimer’s disease, in which it has been demonstrated that patients are more vulnerable to infection-related cognitive changes. This can occur from typical infectious challenges such as respiratory tract infections, although a number of specific viral, bacterial, and fungal pathogens have also been associated with the development of the disease. To date, it is not clear whether these microorganisms are directly related to Alzheimer’s disease progression or if they are opportune pathogens that easily colonize those with dementia and exacerbate the ongoing inflammation observed in these individuals. This review will discuss the impact of each of these challenges, and examine the changes known to occur with age in the peripheral immune system, which may contribute to the age-related vulnerability to infection-induced cognitive decline