17 research outputs found
The 2019 Explosive Eruption of Raikoke Volcanic Island, Kuriles: Pyroclastic Deposits and Their Impact on the Relief and Ecosystems
A short-lived but violent explosive eruption occurred on the small volcanic island Raikoke in June 2019 (central Kuril Islands). The culmination of the eruption lasted 3.5 h and the ash cloud rose to a height of 13 km. An analysis of a sequence of satellite images in combination with ground-based observations gave information on the pyroclastic deposits of the eruption and allowed us to estimate the associated impact on the island ecosystems. We found that this eruption had a phreatomagmatic, sub-Plinian to Plinian character
To be folded, to be unfolded or to be aggregated with important functions: application of the directed coaggregation mechanism to combat bacterial communities
One of the reasons for the mortal danger to humans is the ability of pathogenic bacteria
to form biofilms. The formation of biofilms is an evolutionarily conservative defense
mechanism against adverse conditions. The use of this protection by pathogenic bacteria
reduces the effectiveness of the main means of combating them - antibiotics, which
complicates the production of new types of drugs. There are two types of antimicrobial
agents that are not known antibiotics: nanoparticles and antimicrobial peptides. We
demonstrated that peptides synthesized based on the amino acid sequence of proteins
and capable of amyloid formation and coaggregation with the whole protein exhibit
antimicrobial activity. The ability of peptides to coaggregate with target proteins can help
combat biofilm-forming bacterial communities.
We evaluated the antimicrobial effects of ten synthesized hybrid peptides, which were
obtained based on the sequences of the S1 ribosomal protein of P. aeruginosa and S.
aureus. It is important that some peptides demonstrated high antimicrobial activity
comparable to the antibiotic gentamicin sulfate against pathogenic strains of MRSA, S.
aureus, and P. aeruginosa. These peptides showed no toxicity to eukaryotic cells. Our study
demonstrates the promise of hybrid peptides based on the amyloidogenic regions of the
S1 ribosomal protein for the development of new antimicrobials against Gram-positive
and Gram-negative bacteria resistant to traditional antibiotic.Belgrade : Institute of molecular genetics and genetic engineerin