635 research outputs found
Identifying entrepreneurial potential? An investigation of the identifiers and features of entrepreneurship
Abstract. The paper reports a study of entrepreneurship potential amongst students at one university using a quantitative instrument to measure three of the most commonly cited predictors: access to entrepreneurial role models; urgency of entrepreneurial intent; and desire for economic autonomy. The paper reports also on qualitative interviews with those identified as most and least likely to become entrepreneurs by the measure. Results suggest that the measure is effective and that there is variation between those most and least likely to become entrepreneurs and commonalities amongst those most likely to become entrepreneurs. Of the three predictors 'desire for economic autonomy' is most influential, but the generation of this 'desire' involves various internal and external influences. Findings are of interest to educators insofar as they might identify the stage of entrepreneurial development of students and develop appropriate pedagogic responses. It has implications also for policy aimed at encouraging entrepreneurship, and entrepreneurship support
Development of the OPgunâą for bombardment of animal tissues
A simple and inexpensive particle-bombardment device, the OPgunâą, was constructed for the
delivery of DNA into animal tissues. This device is based on the particle-inflow gun first described
for plant-cell transfection. The delivery of tungsten particles into the epidermis of the mouse ear,
without the use of vacuum and without causing damage to the tissue, was demonstrated. The system
was also shown to be capable of inducing antibodies to a foreign gene in mice.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi.
Adobe Acrobat X Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format
Phosphorus Biogeochemistry Across a Precipitation Gradient in Grasslands of Central North America
Soil P transformations and distribution studies under water limited conditions that characterize many grasslands may provide further insight into the importance of abiotic and biotic P controls within grassdominated ecosystems. We assessed transformations between P pools across four sites spanning the shortgrass steppe, mixed grass prairie, and tallgrass prairie along a 400-mm precipitation gradient across the central Great Plains. Pedon total elemental and constituent mass balance analyses reflected a pattern of increased chemical weathering from the more arid shortgrass steppe to the more mesic tallgrass prairie. Soil surface A horizon P accumulation was likely related to increased biocycling and biological mining. Soluble P, a small fraction of total P in surface A horizons, was greatest at the mixed grass sites. The distribution of secondary soil P fractions across the gradient suggested decreasing Ca-bound P and increasing amounts of occluded P with increasing precipitation. Surface A horizons contained evidence of Ca-bound P in the absence of CaCO3, while in subsurface horizons the Ca-bound P was associated with increasing CaCO3 content. Calcium-bound P, which dominates in water-limited systems, forms under different sets of soil chemical conditions in different climatic regimes, demonstrating the importance of carbonate regulation of P in semi-arid ecosystems
Mental health challenges associated with adaptation and acculturation among international students studying in Scotland
Research has yet to explore the understandings and experiences of mental health, disclosure and help-seeking drawing upon international students' perspectives within the Scottish context. A series of studies were carried out using a multi-method approach including in-depth qualitative interviews with international students studying in Scotland and cross-sectional online surveys comparing domestic and international students in terms of mental health literacy, disclosure and help seeking behaviour. Qualitative data analysed using a thematic approach revealed that adaptation and acculturation difficulties, negative beliefs, stigma and fear of judgement adversely impacted on international students' mental health. Descriptive and inferential statistical analysis of the survey data showed that mental health literacy was positively associated with psychological adaptation, and lower stigma was positively associated with help seeking intention among international students. Supporting international students involves addressing the challenges and barriers in overcoming adaptation and acculturation difficulties that may inhibit disclosure and help seeking for mental health problems
Standard regression-based methods for measuring recovery after sport-related concussion
Clinical decision making about an athlete's return to competition after concussion is hampered by a lack of systematic methods to measure recovery. We applied standard regression-based methods to statistically measure individual rates of impairment at several time points after concussion in college football players. Postconcussive symptoms, cognitive functioning, and balance were assessed in 94 players with concussion (based on American Academy of Neurology Criteria) and 56 noninjured controls during preseason baseline testing, and immediately, 3 hr, and 1, 2, 3, 5, and 7 days postinjury. Ninety-five percent of injured players exhibited acute concussion symptoms and impairment on cognitive or balance testing immediately after injury, which diminished to 4% who reported elevated symptoms on postinjury day 7. In addition, a small but clinically significant percentage of players who reported being symptom free by day 2 continued to be classified as impaired on the basis of objective balance and cognitive testing. These data suggest that neuropsychological testing may be of incremental utility to subjective symptom checklists in identifying the residual effects of sport-related concussion. The implementation of neuropsychological testing to detect subtle cognitive impairment is most useful once postconcussive symptoms have resolved. This management model is also supported by practical and other methodological considerations
K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial
Chronic infectious diseases, such as Helicobacter pylori infection, can promote cancer in a large part through induction of chronic inflammation. Oncogenic K-ras mutation in epithelial cells activates inflammatory pathways, which could compensate for a lack of infectious stimulus. Gastric histopathology and putative progenitor markers [doublecortin and calcium/calmodulin-dependent protein kinase-like 1 (Dcamkl1) and keratin 19 (K19)] in K19-K-ras-V12 (K19-kras) transgenic mice were assessed at 3, 6, 12, and 18 months of age, in comparison with Helicobacter felisâinfected wild-type littermates. Inflammation was evaluated by reverse transcriptionâPCR of proinflammatory cytokines, and K19-kras mice were transplanted with green fluorescent protein (GFP)âlabeled bone marrow. Both H. felis infection and K-ras mutation induced upregulation of proinflammatory cytokines, expansion of Dcamkl1+ cells, and progression to oxyntic atrophy, metaplasia, hyperplasia, and high-grade dysplasia. K19-kras transgenic mice uniquely displayed mucous metaplasia as early as 3 months and progressed to high-grade dysplasia and invasive intramucosal carcinoma by 20 months. In bone marrowâtransplanted K19-kras mice that progressed to dysplasia, a large proportion of stromal cells were GFP+ and bone marrowâderived, but only rare GFP+ epithelial cells were observed. GFP+ bone marrowâderived cells included leukocytes and CD45â stromal cells that expressed vimentin or α smooth muscle actin and were often found surrounding clusters of Dcamkl1+ cells at the base of gastric glands. In conclusion, the expression of mutant K-ras in K19+ gastric epithelial cells can induce chronic inflammation and promote the development of dysplasia.National Institutes of Health (U.S.) (Grant NIH 5R01 CA120979-02)National Institutes of Health (U.S.) (Grant R01 DK060694)National Institutes of Health (U.S.) (Grant U01 CA143056)National Institutes of Health (U.S.) (Grant P30 DK050306)Uehara Memorial Foundatio
Black Hole Spin via Continuum Fitting and the Role of Spin in Powering Transient Jets
The spins of ten stellar black holes have been measured using the
continuum-fitting method. These black holes are located in two distinct classes
of X-ray binary systems, one that is persistently X-ray bright and another that
is transient. Both the persistent and transient black holes remain for long
periods in a state where their spectra are dominated by a thermal accretion
disk component. The spin of a black hole of known mass and distance can be
measured by fitting this thermal continuum spectrum to the thin-disk model of
Novikov and Thorne; the key fit parameter is the radius of the inner edge of
the black hole's accretion disk. Strong observational and theoretical evidence
links the inner-disk radius to the radius of the innermost stable circular
orbit, which is trivially related to the dimensionless spin parameter a_* of
the black hole (|a_*| < 1). The ten spins that have so far been measured by
this continuum-fitting method range widely from a_* \approx 0 to a_* > 0.95.
The robustness of the method is demonstrated by the dozens or hundreds of
independent and consistent measurements of spin that have been obtained for
several black holes, and through careful consideration of many sources of
systematic error. Among the results discussed is a dichotomy between the
transient and persistent black holes; the latter have higher spins and larger
masses. Also discussed is recently discovered evidence in the transient sources
for a correlation between the power of ballistic jets and black hole spin.Comment: 30 pages. Accepted for publication in Space Science Reviews. Also to
appear in hard cover in the Space Sciences Series of ISSI "The Physics of
Accretion onto Black Holes" (Springer Publisher). Changes to Sections 5.2,
6.1 and 7.4. Section 7.4 responds to Russell et al. 2013 (MNRAS, 431, 405)
who find no evidence for a correlation between the power of ballistic jets
and black hole spi
Incidence, clinical course, and predictors of prolonged recovery time following sport-related concussion in high school and college athletes
Sport-related concussion (SRC) is typically followed by clinical recovery within days, but reports of prolonged symptoms are common. We investigated the incidence of prolonged recovery in a large cohort (n = 18,531) of athlete seasons over a 10-year period. A total of 570 athletes with concussion (3.1%) and 166 controls who underwent pre-injury baseline assessments of symptoms, neurocognitive functioning and balance were re-assessed immediately, 3 hr, and 1, 2, 3, 5, 7, and 45 or 90 days after concussion. Concussed athletes were stratified into typical (within 7 days) or prolonged (> 7 days) recovery groups based on symptom recovery time. Ten percent of athletes (n = 57) had a prolonged symptom recovery, which was also associated with lengthier recovery on neurocognitive testing (p <.001). At 45-90 days post-injury, the prolonged recovery group reported elevated symptoms, without deficits on cognitive or balance testing. Prolonged recovery was associated with unconsciousness [odds ratio (OR), 4.15; 95% confidence interval (CI) 2.12-8.15], posttraumatic amnesia (OR, 1.81; 95% CI, 1.00-3.28), and more severe acute symptoms (p <.0001). These results suggest that a small percentage of athletes may experience symptoms and functional impairments beyond the typical window of recovery after SRC, and that prolonged recovery is associated with acute indicators of more severe injury
The Hamiltonian formulation of General Relativity: myths and reality
A conventional wisdom often perpetuated in the literature states that: (i) a
3+1 decomposition of space-time into space and time is synonymous with the
canonical treatment and this decomposition is essential for any Hamiltonian
formulation of General Relativity (GR); (ii) the canonical treatment
unavoidably breaks the symmetry between space and time in GR and the resulting
algebra of constraints is not the algebra of four-dimensional diffeomorphism;
(iii) according to some authors this algebra allows one to derive only spatial
diffeomorphism or, according to others, a specific field-dependent and
non-covariant four-dimensional diffeomorphism; (iv) the analyses of Dirac
[Proc. Roy. Soc. A 246 (1958) 333] and of ADM [Arnowitt, Deser and Misner, in
"Gravitation: An Introduction to Current Research" (1962) 227] of the canonical
structure of GR are equivalent. We provide some general reasons why these
statements should be questioned. Points (i-iii) have been shown to be incorrect
in [Kiriushcheva et al., Phys. Lett. A 372 (2008) 5101] and now we thoroughly
re-examine all steps of the Dirac Hamiltonian formulation of GR. We show that
points (i-iii) above cannot be attributed to the Dirac Hamiltonian formulation
of GR. We also demonstrate that ADM and Dirac formulations are related by a
transformation of phase-space variables from the metric to lapse
and shift functions and the three-metric , which is not canonical. This
proves that point (iv) is incorrect. Points (i-iii) are mere consequences of
using a non-canonical change of variables and are not an intrinsic property of
either the Hamilton-Dirac approach to constrained systems or Einstein's theory
itself.Comment: References are added and updated, Introduction is extended,
Subsection 3.5 is added, 83 pages; corresponds to the published versio
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