Modern Methods for Identification and Quantitative Analysis of Undeclared Phosphodiesterase-5 Inhibitors as Pharmaceutically Active Substances in Dietary Supplements (Review)

This review is devoted to consideration of physicochemical methods for detection of pharmaceutically active substances, in particular, phosphodiesterase-5 (PDE-5) inhibitors, present in dietary supplements. The necessity of using the most informative approaches for the identification of PDE-5 inhibitors registered as drugs and their structurally modified analogs with unknown safety and efficacy in the composition of dietary supplements is emphasized. © 2022, Springer Science+Business Media, LLC, part of Springer Nature

Bioavailability and Safety of Dihydroquercetin (Review)

Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used for treating Middle East respiratory syndrome coronavirus (MERS-CoV) infection and is currently considered a potential regulator of oxidative stress as part of COVID-19 multipurpose therapy. DHQ has a high safety profile but low bioavailability that limits its use. Innovative techniques (liposomization, crystal engineering, etc.) can be used to increase its bioavailability. © 2022, Springer Science+Business Media, LLC, part of Springer Nature