Hypercoiling and hydrophobically associating polymers Interfacial synthesis, surface properties and pharmaceutical applications

SIGLEAvailable from British Library Document Supply Centre-DSC:DXN012425 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Hypercoiling & hydrophobically associating polymers Interfacial synthesis, surface properties & pharmaceutical applications

SIGLEAvailable from British Library Document Supply Centre-DSC:DXN012547 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin

Mycobacteria have a unique cell wall consisting of mycolic acids, very long chain lipids that provide protection and allow the bacteria to persist within human macrophages. Inhibition of cell wall biosynthesis is fatal for the organism and a starting point for the discovery and development of novel antibiotics. We determined the crystal structures of KasA, a key enzyme involved in the biosynthesis of long chain fatty acids, in its apo form and bound to the natural product inhibitor thiolactomycin. Detailed insights into the interaction of the inhibitor with KasA and the identification of a polyethylene glycol molecule that mimics a fatty acid substrate of approximately 40 carbon atoms length, represent the first atomic view of a mycobacterial enzyme involved in the synthesis of long chain fatty acids and provide a robust platform for the development of novel thiolactomycin analogs with high affinity for Kas

Transient IR study of Blue Light Sensing Proteins

In this work we present the identification of redox intermediates of flavin and tryptophan after photoexcitation in glucose oxidase, Y21W AppA mutant and lAppA by the means of TRIR spectroscopy