19 research outputs found
A community-based geological reconstruction of Antarctic Ice Sheet deglaciation since the Last Glacial Maximum
A robust understanding of Antarctic Ice Sheet deglacial history since the Last Glacial Maximum is important in order to constrain ice sheet and glacial-isostatic adjustment models, and to explore the forcing mechanisms responsible for ice sheet retreat. Such understanding can be derived from a broad range of geological and glaciological datasets and recent decades have seen an upsurge in such data gathering around the continent and Sub-Antarctic islands. Here, we report a new synthesis of those datasets, based on an accompanying series of reviews of the geological data, organised by sector. We present a series of timeslice maps for 20ka, 15ka, 10ka and 5ka, including grounding line position and ice sheet thickness changes, along with a clear assessment of levels of confidence. The reconstruction shows that the Antarctic Ice sheet did not everywhere reach the continental shelf edge at its maximum, that initial retreat was asynchronous, and that the spatial pattern of deglaciation was highly variable, particularly on the inner shelf. The deglacial reconstruction is consistent with a moderate overall excess ice volume and with a relatively small Antarctic contribution to meltwater pulse 1a. We discuss key areas of uncertainty both around the continent and by time interval, and we highlight potential priorit. © 2014 The Authors
Expression of Carbohydrate Antigens in the Goat Uterus During Early Pregnancy and on Steroid-Treated Polarized Uterine Epithelial Cells In Vitro1
Some remarks on classical and bayesian reliability estimation of binomial and poisson distributions
Sedimentary facies of a glacially influenced continental succession in the Pennsylvanian Jericho Formation, Galilee Basin, Australia
Recent work on the Late Palaeozoic Ice Age in eastern Australia has shown the Joe Joe Group in the eastern Galilee Basin, Queensland, to be of critical importance as it is one of few records of Pennsylvanian glacial activity outside South America. This paper presents detailed sedimentological data, from which the Late Palaeozoic environment of the region is reconstructed and which, consequently, allows for robust comment on the broader Gondwanan glaciation. The Jericho Formation, in the lower Joe Joe Group, was deposited in an active extensional basin in lacustrine to fluvial environments, during the mid-Namurian to early Stephanian. The region experienced a cool climate during this time, and polythermal mountain or valley-type glaciers periodically advanced into the area from highlands to the north-east. The Jericho Formation preserves a suite of proglacial to terminal glacial facies that is characterized by massive and stratified diamictites deposited from debris flows, massive and horizontally laminated conglomerates and sandstones deposited from hyperconcentrated density flows, laminated siltstones with outsized clasts and interlaminated siltstone/ conglomerate deposited through ice-rafting into lakes, and sedimentary dykes and breccias deposited through overpressurization of groundwater beneath permafrost. Non-glacial facies are dominated by fluvial sandstones and lacustrine/overbank siltstones. The glacigenic rocks of the Jericho Formation are confined to discrete packages, recording three separate glacial advances during the latest Namurian to late Westphalian. This arrangement is consistent with the temporal distribution of glacigenic rocks from around the remainder of Australia and Gondwana, which supports the theory that glacial deposits occurred in discrete intervals. The Joe Joe Group is a key succession in the world in this context as, at this time, eastern Australia provides the only unequivocal evidence of a Namurian/Westphalian glaciation outside South America. The continuous record of sedimentation through the Pennsylvanian and Early Permian is indicative of significant warming between glacial intervals, which is difficult to reconcile with the development of long-lived, cold-based ice sheets across the supercontinent. © 2007 The Authors. Journal compilatio
Differentiation of a colon cancer cell line on a reconstituted basement membrane in vitro
Basement membrane, a thin extracellular matrix, functions as a tissue stabilizer that promotes tissue integrity and differentiated phenotype. We studied a human colon cancer cell line, SNU 61, to evaluate its ability to differentiate on basement membrane. Cells were cultured on plastic, reconstituted basement membrane (Matrigel) or polyhydroxyethyl methacrylate (poly HEMA) for 72 h and evaluated by light and electron microscopy. On Matrigel, the cells showed gland formation with highly polarized cells containing basal nuclei and well developed brush border microvilli on the luminal surface. Apoptosis was noted mainly at the luminal side. On electron microscopic examination, numerous long microvilli, abundant cytoplasmic organelles and intercellular junctions were noted in the Matrigel-cultured cells. Intermediate cytoskeletons were scattered in the cytoplasm and existed on the axes of microvilli. Junctional complexes and desmosomes were frequently formed along intercellular spaces. The cells cultured on poly HEMA, on the other hand, were poorly differentiated and contained a few glandular structures with small lumens. Brush border microvilli, characteristic of enterocytic differentiation, were few in number and were developed on the basal surface. Intermediate filaments and microtubules were fewer than in the Matrigel-cultured cells. Carcinoembryonic antigen was expressed on the luminal surface of the Matrigel-cultured cells and in the cytoplasm of the poly HEMA cultured cells. CD44 stained the basolateral surface in the Matrigel-cultured cells, but the basal side was not stained in the poly HEMA cultured cells. These results are consistent with the different localization of microvilli in the Matrigel and in the poly HEMA cultured cells. Our observations suggest that human colon cancer cells on basement membrane can undergo glandular differentiation and that extracellular matrix is an important factor in morphogenesis