25 research outputs found
Topography of axonal injury as defined by amyloid precursor protein and the sector scoring method in mild and severe closed head injury
Published in Volume: 12 Issue 4: January 29, 2009Abstract not availablePeter C. Blumbergs, Grace Scott, Jim Mana Vis, Helen Wainwright, Donald A. Simpson, A. Jack Mclea
Diffuse axonal injury in head trauma.
Diffuse axonal injury (DAI) as defined by detailed microscopic examination was found in 34 of 80 consecutive cases of head trauma surviving for a sufficient length of time to be clinically assessed by the Royal Adelaide Hospital Neurosurgery Unit. The findings indicate that there is a spectrum of axonal injury and that one third of cases of DAI recovered sufficiently to talk between the initial head injury producing coma and subsequent death. The macroscopic "marker" lesions in the corpus callosum and dorsolateral quadrants of the brainstem were present in only 15/34 of the cases and represented the most severe end of the spectrum of DAI