7 research outputs found
Π€ΠΠΠΠΠΠ’ΠΠΠΠΠΠ§ΠΠ‘ΠΠΠ Π―ΠΠ Π ΠΠΠΠ ΠΠΠΠΠ’Π« ΠΠΠ¨ΠΠ§ΠΠΠΠ
The authors Β discuss the Β theory Β of human Β superorganism and its microbiota (microbiome), whose mutualistic Β interactions Β is realized within the Β microbiota β gut β brain axis that includes endocrine, immune and neurohumoral pathways. The newest concepts Β of microbiome enterotypes and core microbiota Β are Β presented, which are Β important Β for understanding of the Β role of symbiotic Β microorganisms Β in human Β vital activities, for explanation of pathophysiology of many Β chronic Β human Β diseases Β (beyond Β gastrointestinal disorders), as well as for the Β search of effective therapeutic targets. As highly promising are considered Β the functional approaches to studies Β of microbiota Β that Β allowed to formulate the concept Β of phylometabolic (phylofunctional) core. This is a series of evolutionally stable microorganisms Β responsible Β for majority of the Β main microbiome Β functions, such as fermentation Β of polysaccharides Β (glycans), production of short-chain Β fatty acids (butyrate, propionate, acetate), hydrogen Β utilization, production of lactate, metabolism of aminoacids, bile acids, choline, production Β of vitamins and Β some Β biologically active substances β anti-inflammatory, anti-microbial, immunostimulatory. The authors are first to describe the main functional groups Β of microorganisms Β of Β gut microbiota phylometabolic core, providing key metabolic functions, as well as the leading characteristics of the Β phylometabolic core as such. The perspectives Β of modification Β of composition Β and functions Β of phylometabolic microbiota Β core are discussed based on metabiotics Β as a virtually new class of therapeutic agents. A hypothesis has been proposed that Β the Β ratios Β between main Β components of the key gut microbiota may reflect fundamental Β processed Β related Β to a mutualistic interactions between microbiota and human body, as well as they may serve as effective biological markers of dysbiotic states Β determining the Β development of Β various Β pathologic Β conditions. Β For Β example, the Β ratio between Bacteroides spp. and Β butyrate producing Β bacteria Β that Β indirectly indicates Β total numbers Β of microbial genes Β can be used both for assessment of chronic inflammation of various localization (starting Β from inflammatory Β bowel disease to fat tissue inflammation related to metabolic syndrome), and for control of treatment efficacy.ΠΠ²ΡΠΎΡΡ ΠΎΠ±ΡΡΠΆΠ΄Π°ΡΡ ΡΠ΅ΠΎΡΠΈΡ ΡΠ²Π΅ΡΡ
ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ Π΅Π³ΠΎ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ (ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠΌΠ°), ΠΌΡΡΡΠ°Π»ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΊΠΎΡΠΎΡΡΠΌΠΈ ΡΠ΅Π°Π»ΠΈΠ·ΡΡΡΡΡ Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
ΠΎΡΠΈ Β«ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΠ° β ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊ β ΠΌΠΎΠ·Π³Β», Π²ΠΊΠ»ΡΡΠ°ΡΡΠ΅ΠΉ Π² ΡΠ΅Π±Ρ ΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΡΠ΅, ΠΈΠΌΠΌΡΠ½Π½ΡΠ΅ Β ΠΈ Π½Π΅ΠΉΡΠΎΠ³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΡΠ΅ ΠΏΡΡΠΈ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ Π½ΠΎΠ²Π΅ΠΉΡΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΈ ΡΠ½ΡΠ΅ΡΠΎΡΠΈΠΏΠΎΠ² Β ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠΌΠ° Β ΠΈ ΠΊΠ»ΡΡΠ΅Π²ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° (ΡΠ΄ΡΠ° ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ), Π²Π°ΠΆΠ½ΡΠ΅ Π΄Π»Ρ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΡ ΡΠΎΠ»ΠΈ ΡΠΈΠΌΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π² ΠΆΠΈΠ·Π½Π΅Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° Β ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΎΠ±ΡΡΡΠ½Π΅Π½ΠΈΡ Β ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΌΠ½ΠΎΠ³ΠΈΡ
Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Β ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° (Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ Π³Π°ΡΡΡΠΎΡΠ½ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
), Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠΎΠΈΡΠΊΠ° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠΈΡΠ΅Π½Π΅ΠΉ. ΠΠΎΠΊΠ°Π·Π°Π½Π° ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ-ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ²ΡΠΈΡ
Π²ΡΠ΄Π²ΠΈΠ½ΡΡΡ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΡ ΡΠΈΠ»ΠΎΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ (ΡΠΈΠ»ΠΎΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ) Β ΡΠ΄ΡΠ°, ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡΠ΅Π³ΠΎ ΡΠΎΠ±ΠΎΠΉ Π½Π°Π±ΠΎΡ ΡΠ²ΠΎΠ»ΡΡΠΈΠΎΠ½Π½ΠΎ ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
Π²ΠΈΠ΄ΠΎΠ² ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ², ΠΎΡΠ²Π΅ΡΠ°ΡΡΠΈΡ
Π·Π° Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ Β ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ, ΡΠ°ΠΊΠΈΡ
ΠΊΠ°ΠΊ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΡ Β ΠΏΠΎΠ»ΠΈΡΠ°Ρ
Π°ΡΠΈΠ΄ΠΎΠ² Β (Π³Π»ΠΈΠΊΠ°Π½ΠΎΠ²), Β ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΡ ΠΊΠΎΡΠΎΡΠΊΠΎΡΠ΅ΠΏΠΎΡΠ΅ΡΠ½ΡΡ
ΠΆΠΈΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ (Π±ΡΡΠΈΡΠ°Ρ, ΠΏΡΠΎΠΏΠΈΠΎΠ½Π°Ρ, Π°ΡΠ΅ΡΠ°Ρ), ΡΡΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ Β Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Π°, ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΡ Π»Π°ΠΊΡΠ°ΡΠ°, ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ, ΠΆΠ΅Π»ΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ, Ρ
ΠΎΠ»ΠΈΠ½Π°, ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΡ Β Π²ΠΈΡΠ°ΠΌΠΈΠ½ΠΎΠ² ΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
Β Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Β Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ β ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
, Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΡΡ
, ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΈΠΌΡΠ»ΠΈΡΡΡΡΠΈΡ
. ΠΠ²ΡΠΎΡΠ°ΠΌΠΈ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ Π³ΡΡΠΏΠΏΡ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠΈΠ»ΠΎΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΄ΡΠ° ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ°, ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡΠΈΠ΅ ΠΊΠ»ΡΡΠ΅Π²ΡΠ΅ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Β ΡΡΠ½ΠΊΡΠΈΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ Π²Π΅Π΄ΡΡΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΡΠ°ΠΌΠΎΠ³ΠΎ ΡΠΈΠ»ΠΎΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Β ΡΠ΄ΡΠ°. Β ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ Β ΡΠΎΡΡΠ°Π²Π° Β ΠΈ Β ΡΡΠ½ΠΊΡΠΈΠΉ ΡΠΈΠ»ΠΎΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΄ΡΠ° ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΈΠ°Π»ΡΠ½ΠΎ Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π³Π΅Π½ΡΠΎΠ² β ΠΌΠ΅ΡΠ°Π±ΠΈΠΎΡΠΈΠΊΠΎΠ². ΠΡΠ΄Π²ΠΈΠ½ΡΡΠΎ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅, ΡΡΠΎ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°ΠΌΠΈ Β ΠΊΠ»ΡΡΠ΅Π²ΠΎΠΉ Β ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ Β ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° Β ΠΎΡΡΠ°ΠΆΠ°ΡΡ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ Β ΠΏΡΠΎΡΠ΅ΡΡΡ, Β ΡΠ²ΡΠ·Π°Π½Π½ΡΠ΅ Ρ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ ΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° Β ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΈ Β ΠΌΠΎΠ³ΡΡ ΡΠ»ΡΠΆΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠ°ΠΌΠΈ Π΄ΠΈΡΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡΠΈΡ
Β ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Β ΡΠΎΠΉ ΠΈΠ»ΠΈ ΠΈΠ½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΠ°ΠΏΡΠΈΠΌΠ΅Ρ, ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ Β ΠΌΠ΅ΠΆΠ΄Ρ Π±Π°ΠΊΡΠ΅ΡΠΎΠΈΠ΄Π°ΠΌΠΈ ΠΈ Π±ΡΡΠΈΡΠ°Ρ-ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡΠΈΠΌΠΈ Β Π±Π°ΠΊΡΠ΅ΡΠΈΡΠΌΠΈ, ΠΊΠΎΡΠ²Π΅Π½Π½ΠΎ ΡΠΊΠ°Π·ΡΠ²Π°ΡΡΠ΅Π΅ Π½Π° ΠΎΠ±ΡΠ΅Π΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΌΠΈΠΊΡΠΎΠ±Π½ΡΡ
Π³Π΅Π½ΠΎΠ², ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΎ ΠΊΠ°ΠΊ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ Β Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ Β (ΠΎΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° Π΄ΠΎ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Β Π² ΠΆΠΈΡΠΎΠ²ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ, ΡΠ²ΡΠ·Π°Π½Π½ΡΡ
Ρ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ), ΡΠ°ΠΊ ΠΈ Π΄Π»Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠΌΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ
Π ΠΎΠ»Ρ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π½Π΅Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ ΠΆΠΈΡΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ
The review deals with the role of aromatic amino acids and their microbial metabolites in the development and progression of non-alcoholic fatty liver disease (NAFLD). Pathological changes typical for NAFLD, as well as abnormal composition and/or functional activity of gut microbiota, results in abnormal aromatic amino acid metabolism. The authors discuss the potential of these amino acids and their bacterial metabolites to produce both negative and positive impact on the main steps of NAFLD pathophysiology, such as lipogenesis and inflammation, as well as on the liver functions through regulation of the intestinal barrier and microbiota-gut-liver axis signaling. The review gives detailed description of the mechanism of biological activity of tryptophan and its derivatives (indole, tryptamine, indole-lactic, indole-propyonic, indole-acetic acids, and indole-3-aldehyde) through the activation of aryl hydrocarbon receptor (AhR), preventing the development of liver steatosis. Bacteria-produced phenyl-alanine metabolites could promote liver steatosis (phenyl acetic and phenyl lactic acids) or, on the contrary, could reduce liver inflammation and increase insulin sensitivity (phenyl propionic acid). Tyramine, para-cumarate, 4-hydroxyphenylacetic acids, being by-products of bacterial catabolism of tyrosine, can prevent NAFLD, whereas para-cresol and phenol accelerate the progression of NAFLD by damaging the barrier properties of intestinal epithelium. Abnormalities in bacterial catabolism of tyrosine, leading to its excess, stimulate fatty acid synthesis and promote lipid infiltration of the liver. The authors emphasize aΒ close interplay between bacterial metabolism of aromatic amino acids by gut microbiota and the functioning of the human body. They hypothesize that microbial metabolites of aromatic amino acids may represent not only therapeutic targets or non-invasive biomarkers, but also serve as bioactive agents for NAFLD treatment and prevention.ΠΠ±Π·ΠΎΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½ ΡΠΎΠ»ΠΈ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ ΠΈΒ ΠΈΡ
Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
Π²Β ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΈΒ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π½Π΅Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ ΠΆΠΈΡΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ (ΠΠΠΠΠ). ΠΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΠ΅ ΠΏΡΠΈ ΠΠΠΠΠ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π²Β ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅, Π°Β ΡΠ°ΠΊΠΆΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΡΡΠ°Π²Π° ΠΈ/ΠΈΠ»ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡ ΠΊΒ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ. ΠΠ±ΡΡΠΆΠ΄Π°Π΅ΡΡΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΡΡΠΈΡ
Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ ΠΈΒ ΠΈΡ
Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ ΠΊΠ°ΠΊ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ΅, ΡΠ°ΠΊ ΠΈΒ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° Π³Π»Π°Π²Π½ΡΠ΅ Π·Π²Π΅Π½ΡΡ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΠΠΠΠΒ β Π»ΠΈΠΏΠΎΠ³Π΅Π½Π΅Π· ΠΈΒ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅, Π°Β ΡΠ°ΠΊΠΆΠ΅ Π½Π° ΡΡΠ½ΠΊΡΠΈΡ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΡΠ΅ΡΠ΅Π· ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠ³ΠΎ Π±Π°ΡΡΠ΅ΡΠ° ΠΈΒ ΡΠΈΠ³Π½Π°Π»ΠΎΠ² ΠΎΡΠΈ Β«ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΠ°Β β ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΒ β ΠΏΠ΅ΡΠ΅Π½ΡΒ». ΠΠΎΠ΄ΡΠΎΠ±Π½ΠΎ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΠΈΠΏΡΠΎΡΠ°Π½Π° ΠΈΒ Π΅Π³ΠΎ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
(ΠΈΠ½Π΄ΠΎΠ», ΡΡΠΈΠΏΡΠ°ΠΌΠΈΠ½, ΠΈΠ½Π΄ΠΎΠ»ΠΌΠΎΠ»ΠΎΡΠ½Π°Ρ, ΠΈΠ½Π΄ΠΎΠ»ΠΏΡΠΎΠΏΠΈΠΎΠ½ΠΎΠ²Π°Ρ, ΠΈΠ½Π΄ΠΎΠ»ΡΠΊΡΡΡΠ½Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΡ, ΠΈΠ½Π΄ΠΎΠ»-3-Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄) Π·Π° ΡΡΠ΅Ρ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π°ΡΠΈΠ»ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° AhR, ΡΡΠΎ ΠΏΡΠ΅Π΄ΠΎΡΠ²ΡΠ°ΡΠ°Π΅Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΡΡΠ΅Π°ΡΠΎΠ·Π° ΠΏΠ΅ΡΠ΅Π½ΠΈ. ΠΠ°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΏΡΠΎΠ΄ΡΠΊΡΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° ΡΠ΅Π½ΠΈΠ»Π°Π»Π°Π½ΠΈΠ½Π° ΠΌΠΎΠ³ΡΡ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΡΠ΅Π°ΡΠΎΠ·Π° ΠΏΠ΅ΡΠ΅Π½ΠΈ (ΡΠ΅Π½ΠΈΠ»ΡΠΊΡΡΡΠ½Π°Ρ ΠΈΒ ΡΠ΅Π½ΠΈΠ»ΠΌΠΎΠ»ΠΎΡΠ½Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΡ) Π»ΠΈΠ±ΠΎ, Π½Π°ΠΏΡΠΎΡΠΈΠ², ΡΠ½ΠΈΠΆΠ°ΡΡ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅ Π²Β ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈΒ ΠΏΠΎΠ²ΡΡΠ°ΡΡ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΊΒ ΠΈΠ½ΡΡΠ»ΠΈΠ½Ρ (ΡΠ΅Π½ΠΈΠ»ΠΏΡΠΎΠΏΠΈΠΎΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ°). Π’ΠΈΡΠ°ΠΌΠΈΠ½, ΠΏΠ°ΡΠ°-ΠΊΡΠΌΠ°ΡΠ°Ρ, 4-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΡΠ΅Π½ΠΈΠ»ΡΠΊΡΡΡΠ½Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ°Β β ΠΏΡΠΎΠ΄ΡΠΊΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° ΡΠΈΡΠΎΠ·ΠΈΠ½Π°Β β ΠΌΠΎΠ³ΡΡ ΠΏΡΠ΅Π΄ΠΎΡΠ²ΡΠ°ΡΠ°ΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΠΠΠΠ, ΡΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ ΠΏΠ°ΡΠ°-ΠΊΡΠ΅Π·ΠΎΠ» ΠΈΒ ΡΠ΅Π½ΠΎΠ» ΡΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΡΡ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΠΠΠΠ ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π±Π°ΡΡΠ΅ΡΠ½ΡΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ. ΠΠ°ΡΡΡΠ΅Π½ΠΈΠ΅ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° ΡΠΈΡΠΎΠ·ΠΈΠ½Π°, ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡΠ΅Π΅ ΠΊΒ Π΅Π³ΠΎ ΠΈΠ·Π±ΡΡΠΊΡ, ΡΡΠΈΠΌΡΠ»ΠΈΡΡΠ΅Ρ ΡΠΈΠ½ΡΠ΅Π· ΠΆΠΈΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ ΠΈΒ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ ΠΎΡΠ»ΠΎΠΆΠ΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² Π²Β ΠΏΠ΅ΡΠ΅Π½ΠΈ. ΠΠ²ΡΠΎΡΡ ΠΏΠΎΠ΄ΡΠ΅ΡΠΊΠΈΠ²Π°ΡΡ ΡΠ΅ΡΠ½ΠΎΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΠ΅ΠΆΠ΄Ρ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠΌ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠΎΠΌ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ, ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ΅ΠΌΡΠΌ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΠΎΠΉ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ°, ΠΈΒ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΡΡΠΊΠ°Π·ΡΠ²Π°Π΅ΡΡΡ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ ΠΎΒ ΡΠΎΠΌ, ΡΡΠΎ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ ΠΌΠΎΠ³ΡΡ Π²ΡΡΡΡΠΏΠ°ΡΡ Π²Β ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠΈΡΠ΅Π½Π΅ΠΉ ΠΈΠ»ΠΈ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΡ
Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ², Π½ΠΎ ΠΈΒ Π±ΠΈΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ
Π°Π³Π΅Π½ΡΠΎΠ² Π΄Π»Ρ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΈΒ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΠΠΠΠ
ΠΠΎΠ»Π΅Π·Π½Ρ ΠΡΠΎΠ½Π° Ρ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΊΠ°ΠΊ ΠΏΡΠΈΠΌΠ΅Ρ ΡΠ΅Π΄ΠΊΠΎΠ³ΠΎ ΡΠ΅Π½ΠΎΡΠΈΠΏΠ° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ: ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅
Crohn's disease (CD), along with ulcerative colitis, is one of the predominant nosological forms of inflammatory bowel diseases. In CD, any part of the gastrointestinal tract can be affected; however, the process is commonly associated with terminal ileum or colon involvement. CD cases with isolated or mixed involvement of upper gastrointestinal tract (esophagus, stomach, and duodenum) are rare and least studied types of the disease. In isolated stomach involvement, the complaints are non-specific and include epigastric pain, gastric dyspepsia, early satiety, decreased appetite, and nausea. Isolated CD of upper gastrointestinal tract can be diagnosed after comprehensive work-up and always requires a high diagnostic level, including clinical, endoscopic and morphological one. We present a clinical case of CD with isolated stomach involvement in a 62-year-old woman. The diagnosis was confirmed by the histopathological findings of an epithelioid cell granuloma in the gastric antrum. Treatment with systemic corticosteroids reduced the disease clinical activity and improved the histological characteristics of the gastric biopsy sampled obtained by endoscopy. In this clinical case, there were specific macroscopic gastric lesions found at endoscopy in CD patients with upper gastrointestinal tract involvement, which is characterized by thickened longitudinal folding and linear grooves. This type of lesion has been described in the literature as βbamboo joint-like appearanceβ.Conclusion: Comprehensive assessment of clinical manifestations, endoscopic and histopathological specific features is crucial for the timely diagnosis and treatment of inflammatory bowel diseases.ΠΠΎΠ»Π΅Π·Π½Ρ ΠΡΠΎΠ½Π° (ΠΠ) Π½Π°ΡΡΠ΄Ρ Ρ ΡΠ·Π²Π΅Π½Π½ΡΠΌ ΠΊΠΎΠ»ΠΈΡΠΎΠΌ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ ΠΎΠ΄Π½Ρ ΠΈΠ· ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΡ
Π½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΠΌ Π² ΡΡΡΡΠΊΡΡΡΠ΅ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ°. ΠΡΠΈ ΠΠ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΏΠΎΡΠ°ΠΆΠ΅Π½Π° Π»ΡΠ±Π°Ρ ΡΠ°ΡΡΡ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎ-ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΠ° (ΠΠΠ’), Π½ΠΎ ΠΎΠ±ΡΡΠ½ΠΎ ΠΏΡΠΎΡΠ΅ΡΡ ΡΠ²ΡΠ·Π°Π½ Ρ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ΄Π΅Π»Π° ΠΏΠΎΠ΄Π²Π·Π΄ΠΎΡΠ½ΠΎΠΉ ΠΈΠ»ΠΈ ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ. Π‘Π»ΡΡΠ°ΠΈ ΠΠ Ρ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΈΠ»ΠΈ ΡΠΎΡΠ΅ΡΠ°Π½Π½ΡΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π²Π΅ΡΡ
Π½ΠΈΡ
ΠΎΡΠ΄Π΅Π»ΠΎΠ² ΠΠΠ’ (ΠΏΠΈΡΠ΅Π²ΠΎΠ΄Π°, ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΈ Π΄Π²Π΅Π½Π°Π΄ΡΠ°ΡΠΈΠΏΠ΅ΡΡΡΠ½ΠΎΠΉ ΠΊΠΈΡΠΊΠΈ) β ΡΠ΅Π΄ΠΊΠΎ Π²ΡΡΡΠ΅ΡΠ°Π΅ΠΌΡΠ΅ ΠΈ Π½Π°ΠΈΠΌΠ΅Π½Π΅Π΅ ΠΈΠ·ΡΡΠ΅Π½Π½ΡΠ΅ Π²Π°ΡΠΈΠ°Π½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΡΠΈ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΈ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΆΠ°Π»ΠΎΠ±Ρ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½Ρ ΠΈ Π²ΠΊΠ»ΡΡΠ°ΡΡ Π±ΠΎΠ»ΠΈ Π² ΡΠΏΠΈΠ³Π°ΡΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ, ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΡΡ Π΄ΠΈΡΠΏΠ΅ΠΏΡΠΈΡ, ΡΡΠ²ΡΡΠ²ΠΎ ΡΠ°Π½Π½Π΅Π³ΠΎ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ, ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π°ΠΏΠΏΠ΅ΡΠΈΡΠ°, ΡΠΎΡΠ½ΠΎΡΡ. ΠΠΈΠ°Π³Π½ΠΎΠ· ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΠ Π²Π΅ΡΡ
Π½ΠΈΡ
ΠΎΡΠ΄Π΅Π»ΠΎΠ² ΠΠΠ’ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ ΠΏΡΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠΌ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ, ΡΡΠΎ Π²ΡΠ΅Π³Π΄Π° ΡΡΠ΅Π±ΡΠ΅Ρ Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ (ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ, ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠΉ, ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ). Π ΡΡΠ°ΡΡΠ΅ Π΄Π°Π½ΠΎ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΠ Ρ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° Ρ 62-Π»Π΅ΡΠ½Π΅ΠΉ ΠΆΠ΅Π½ΡΠΈΠ½Ρ. ΠΠΈΠ°Π³Π½ΠΎΠ· Π±ΡΠ» ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ ΡΠΏΠΈΡΠ΅Π»ΠΈΠΎΠΈΠ΄Π½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π³ΡΠ°Π½ΡΠ»Π΅ΠΌΡ Π² Π°Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΎΡΠ΄Π΅Π»Π΅ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΏΡΠΈ ΠΏΠ°ΡΠΎΠ³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ. ΠΠ° ΡΠΎΠ½Π΅ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΠΌΠΈ Π³Π»ΡΠΊΠΎΠΊΠΎΡΡΠΈΠΊΠΎΡΡΠ΅ΡΠΎΠΈΠ΄Π°ΠΌΠΈ Π΄ΠΎΡΡΠΈΠ³Π½ΡΡΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈ ΡΠ»ΡΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ Π±ΠΈΠΎΠΏΡΠ°ΡΠΎΠ² ΠΈΠ· ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΏΡΠΈ ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΠΈ. Π Π½Π°ΡΠ΅ΠΌ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠΈ Π±ΡΠ»ΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΌΠ°ΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°, Π½Π°Π±Π»ΡΠ΄Π°Π΅ΠΌΠΎΠ΅ ΠΏΡΠΈ ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠ Π²Π΅ΡΡ
Π½ΠΈΡ
ΠΎΡΠ΄Π΅Π»ΠΎΠ² ΠΠΠ’, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠ΅Π΅ΡΡ ΡΡΠΎΠ»ΡΠ΅Π½Π½ΡΠΌΠΈ ΠΏΡΠΎΠ΄ΠΎΠ»ΡΠ½ΡΠΌΠΈ ΡΠΊΠ»Π°Π΄ΠΊΠ°ΠΌΠΈ ΠΈ Π»ΠΈΠ½Π΅ΠΉΠ½ΡΠΌΠΈ Π±ΠΎΡΠΎΠ·Π΄Π°ΠΌΠΈ, ΠΎΠΏΠΈΡΠ°Π½Π½ΠΎΠ΅ ΡΠ°Π½Π΅Π΅ Π² Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ΅ ΠΊΠ°ΠΊ Β«ΡΠΎΡΠ»Π΅Π½Π΅Π½ΠΈΡ ΡΡΠ²ΠΎΠ»Π° Π±Π°ΠΌΠ±ΡΠΊΠΎΠ²ΠΎΠ³ΠΎ Π΄Π΅ΡΠ΅Π²Π°Β» (Π°Π½Π³Π». bamboo-joint-like appearance).ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½Π°Ρ ΠΎΡΠ΅Π½ΠΊΠ° ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ, ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π³ΠΈΡΡΠΎΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΈΠΌΠ΅Π΅Ρ ΡΠ΅ΡΠ°ΡΡΠ΅Π΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π΄Π»Ρ ΡΠ²ΠΎΠ΅Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ°
Π€ΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΉ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ° ΠΎΠ±ΡΠ°ΡΠ½ΠΎΠ³ΠΎ Π·Π°Ρ Π²Π°ΡΠ° ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½Π° Π³Π΅Π½Π° SLC6A4 ΠΏΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ Π²Π°ΡΠΈΠ°Π½ΡΠ°Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΡΠ°Π·Π΄ΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ°
Rationale: Irritable bowel syndrome (IBS) is a multifactorial disease, the genetic aspect of which is being actively studied.Aim: To investigate functional polymorphism of the serotonin reuptake transporter (SERT) SLC6A4 gene of various clinical variants of IBS.Materials and methods: We performed a cross-sectional single center study in 79 Caucasian patients with IBS (according to the Rome criteria IV). The patients were divided into two groups: group 1, IBS with diarrhea (IBS-D, n = 45) and group 2, IBS with constipation (IBS-C, n = 34). The control group included 59 Caucasian patients with gastrointestinal disorders without IBS. Polymorphism 5-HTTLPR of the SLC6A4 gene was assessed in all subjects. In group 1 patients, blood serotonin levels were measured and psychological tests were performed, including Spielberger's State / Trait Anxiety Inventory, quality of life by SF36 and GSRS, Asthenia scale, VAS scores for pain intensity.Results: Thirty-five of 45 (77.8%) patients with IBS-D carried the mutant S allele, which was significantly more frequent than in the IBS-C group (p = 0.002) and in the control group (p = 0.005). There were no statistically significant differences (p = 0.54) in the frequency of detection of the homozygous LL genotype (normal allele) and the heteroand homozygous mutant alleles (SL and SS) genotype between the IBS-C and control patients. In the IBS-D group, a gender difference for the mutant SS allele of 5-HTTLPR was found, with significantly higher frequency in female patients (p = 0.0147). No significant gender differences in the genotype distribution between the patients with IBS-C and the control group were found. There were also no differences in blood serotonin levels in the IBS patients with various 5-HTTLPR types (p = 0.086); they were all in the reference range. However, there was a trend towards lower serotonin levels in the LL genotype carriers compared to those with the SS/SL polymorphisms. The Gastroenterological inventory GSRS demonstrated significantly higher total score for the constipation syndrome in the patients with homozygous LL 5-HTTLPR polymorphism, compared to that in the patients with the SS/SL genotype (p = 0.013).Conclusion: The results may be related to lower expression of the SLC6A4 gene in the carriers of the mutant allele in the 5-HTTLPR promoter and subsequent decreased rate of serotonin uptake, with resulting stimulation of the gastrointestinal tract. The SERT polymorphism of the SLC6A4 gene is worth further investigation as a potential candidate gene in the IBS pathophysiology.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. Π‘ΠΈΠ½Π΄ΡΠΎΠΌ ΡΠ°Π·Π΄ΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° (Π‘Π Π) ΠΎΡΠ½ΠΎΡΠΈΡΡΡ ΠΊ ΠΌΠ½ΠΎΠ³ΠΎΡΠ°ΠΊΡΠΎΡΠ½ΡΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌ, Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°ΡΠΏΠ΅ΠΊΡ ΠΊΠΎΡΠΎΡΡΡ
Π½Π°Ρ
ΠΎΠ΄ΠΈΡΡΡ Π² ΡΠΎΠΊΡΡΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ.Π¦Π΅Π»Ρ β ΠΈΠ·ΡΡΠΈΡΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΉ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ° ΠΎΠ±ΡΠ°ΡΠ½ΠΎΠ³ΠΎ Π·Π°Ρ
Π²Π°ΡΠ° ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½Π° Π³Π΅Π½Π° SLC6A4 ΠΏΡΠΈ ΡΠ°Π·Π½ΡΡ
ΡΠΎΡΠΌΠ°Ρ
Π‘Π Π.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΏΠΎΠΏΠ΅ΡΠ΅ΡΠ½ΠΎΠ΅ (ΠΎΠ΄Π½ΠΎΠΌΠΎΠΌΠ΅Π½ΡΠ½ΠΎΠ΅) ΠΎΠ΄Π½ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΡΠ½ΠΎΠ²Π½ΡΡ Π³ΡΡΠΏΠΏΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 79 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π΅Π²ΡΠΎΠΏΠ΅ΠΎΠΈΠ΄Π½ΠΎΠΉ ΡΠ°ΡΡ Ρ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Π‘Π Π (ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ Π ΠΈΠΌΡΠΊΠΈΠΌΠΈ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌΠΈ IV ΠΏΠ΅ΡΠ΅ΡΠΌΠΎΡΡΠ°), ΠΊΠΎΡΠΎΡΡΡ
ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ»ΠΈ Π½Π° 2 ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΡ: Π‘Π Π Ρ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ΠΌ Π΄ΠΈΠ°ΡΠ΅ΠΈ (Π‘Π Π-Π, n = 45) ΠΈ Π‘Π Π Ρ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ΠΌ Π·Π°ΠΏΠΎΡΠΎΠ² (Π‘Π Π-Π, n = 34). Π ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ Π³ΡΡΠΏΠΏΡ Π²ΠΎΡΠ»ΠΈ 59 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π΅Π²ΡΠΎΠΏΠ΅ΠΎΠΈΠ΄Π½ΠΎΠΉ ΡΠ°ΡΡ Π³Π°ΡΡΡΠΎΡΠ½ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΈΠ»Ρ Π±Π΅Π· Π‘Π Π. ΠΡΠ΅ΠΌ Π²ΠΊΠ»ΡΡΠ΅Π½Π½ΡΠΌ Π² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· Ρ ΡΠ΅Π»ΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° 5-HTTLPR Π³Π΅Π½Π° SLC6A4. Π ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½Π° Π² ΠΊΡΠΎΠ²ΠΈ, ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Ρ ΠΎΡΠ΅Π½ΠΊΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΈ Π»ΠΈΡΠ½ΠΎΡΡΠ½ΠΎΠΉ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΎΠΏΡΠΎΡΠ½ΠΈΠΊΠ° Π‘ΠΏΠΈΠ»Π±Π΅ΡΠ³Π΅ΡΠ° β Π₯Π°Π½ΠΈΠ½Π°, ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΆΠΈΠ·Π½ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΎΠΏΡΠΎΡΠ½ΠΈΠΊΠΎΠ² SF-36 ΠΈ GSRS, Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ Π°ΡΡΠ΅Π½ΠΈΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΊΠ°Π»Ρ Π°ΡΡΠ΅Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ, ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡ Π±ΠΎΠ»ΠΈ ΠΏΠΎ Π²ΠΈΠ·ΡΠ°Π»ΡΠ½ΠΎΠΉ Π°Π½Π°Π»ΠΎΠ³ΠΎΠ²ΠΎΠΉ ΡΠΊΠ°Π»Π΅.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π‘Π Π-Π ΡΠ°ΡΡΠΎΡΠ° Π½ΠΎΡΠΈΡΠ΅Π»ΡΡΡΠ²Π° ΠΌΡΡΠ°Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π»Π»Π΅Π»Ρ S ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 77,8% (35 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΈΠ· 45), ΡΡΠΎ ΠΎΠΊΠ°Π·Π°Π»ΠΎΡΡ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Π² Π³ΡΡΠΏΠΏΠ΅ Π‘Π Π-Π (Ρ = 0,002) ΠΈ Π² ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ (Ρ = 0,005). ΠΠ΅ΠΆΠ΄Ρ Π³ΡΡΠΏΠΏΠΎΠΉ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π‘Π Π-Π ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΌ Π½Π΅ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΎ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΡ
ΡΠ°Π·Π»ΠΈΡΠΈΠΉ (Ρ = 0,54) Π² ΡΠ°ΡΡΠΎΡΠ΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΠΎΠ³ΠΎ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° ΠΏΠΎ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΌΡ Π°Π»Π»Π΅Π»Ρ (LL) ΠΈ Π³Π΅ΡΠ΅ΡΠΎΠΈ Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΠΎΠ³ΠΎ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° Ρ ΠΌΡΡΠ°Π½ΡΠ½ΡΠΌ Π°Π»Π»Π΅Π»Π΅ΠΌ (SL ΠΈ SS). Π Π³ΡΡΠΏΠΏΠ΅ Π‘Π Π-Π Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π³Π΅Π½Π΄Π΅ΡΠ½ΠΎΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΠ΅: Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΡΠΉ Π³Π΅Π½ΠΎΡΠΈΠΏ ΠΏΠΎ ΠΌΡΡΠ°Π½ΡΠ½ΠΎΠΌΡ Π°Π»Π»Π΅Π»Ρ (SS) 5-HTTLPR ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎ ΡΠ°ΡΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΡΡ Ρ ΠΆΠ΅Π½ΡΠΈΠ½ (p = 0,0147); Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² c Π‘Π Π-Π ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΡ
Π³Π΅Π½Π΄Π΅ΡΠ½ΡΡ
ΡΠ°Π·Π»ΠΈΡΠΈΠΉ Π² ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° Π½Π΅ Π±ΡΠ»ΠΎ. Π£ΡΠΎΠ²Π΅Π½Ρ ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½Π° Π² ΠΊΡΠΎΠ²ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π‘Π Π Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° 5-HTTLPR Π½Π΅ ΡΠ°Π·Π»ΠΈΡΠ°Π»ΡΡ (p = 0,086) ΠΈ Π±ΡΠ» Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
ΡΠ΅ΡΠ΅ΡΠ΅Π½ΡΠ½ΡΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ, ΠΎΠ΄Π½Π°ΠΊΠΎ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΠΎΡΠΌΠ΅ΡΠΈΡΡ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½Π° Ρ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ LL ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π½ΠΎΡΠΈΡΠ΅Π»ΡΠΌΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² SS/SL. ΠΠ½Π°Π»ΠΈΠ· Π³Π°ΡΡΡΠΎΡΠ½ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠΏΡΠΎΡΠ½ΠΈΠΊΠ° GSRS ΠΏΠΎΠΊΠ°Π·Π°Π» ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠ΅ (p = 0,013) ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΌΠΌΠ°ΡΠ½ΠΎΠ³ΠΎ Π±Π°Π»Π»Π° ΠΊΠΎΠ½ΡΡΠΈΠΏΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΡΠΌ LL ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠΌ 5-HTTLPR ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠΌ SS/SL.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΡΠ²Π»Π΅Π½Π½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Ρ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΠΎΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΉ Π³Π΅Π½Π° SLC6A4 Ρ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ ΠΌΡΡΠ°Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π»Π»Π΅Π»Ρ Π² ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ΅ 5-HTTLPR ΠΈ ΠΊΠ°ΠΊ ΡΠ΅Π·ΡΠ»ΡΡΠ°Ρ β Π·Π°ΠΌΠ΅Π΄Π»Π΅Π½Π½ΠΎΠΉ ΡΠΊΠΎΡΠΎΡΡΡΡ ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½ΠΈΡ ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½Π°, ΠΊΠΎΡΠΎΡΡΠΉ ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ ΡΡΠΈΠΌΡΠ»ΠΈΡΡΡΡΠ΅Π΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎ-ΠΊΠΈΡΠ΅ΡΠ½ΡΠΉ ΡΡΠ°ΠΊΡ. ΠΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ° ΠΎΠ±ΡΠ°ΡΠ½ΠΎΠ³ΠΎ Π·Π°Ρ
Π²Π°ΡΠ° ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½Π° Π³Π΅Π½Π° SLC6A4 Π·Π°ΡΠ»ΡΠΆΠΈΠ²Π°Π΅Ρ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π³ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΊΠ°ΠΊ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠΉ Π³Π΅Π½-ΠΊΠ°Π½Π΄ΠΈΠ΄Π°Ρ Π² ΠΏΠ°ΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ Π‘Π Π
Organizing and the Search for Excellence: Making Sense of the Times in Theory and Practice
This paper seeks to draw out commonalities between the organizational/practitioners' and academic agenda and to explore the idea that academe may not only reflect the times but also help to create them. In so doing, it examines the extent to which In Search of Excellence, a significant and timely exemplar of the organizational agenda, in effect operationalized The Social Psychology of Organizing. If, it concludes, sensemaking is retrospective, then how can it help us to think about current issues that require action and shape our conversations and sensemaking about time future? To this end, much of academic management treats much of management practice as beyond the pale and, for that reason, what matters in this paper is not just a consideration of how to break out of Hambrick's closed loop, but also how others can be encouraged to break in. We see this as part of an ongoing conversation that matters.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68948/2/10.1177_135050849961006.pd