Optical flow tracking velocimetry of near-field explosions

To better understand the complex dynamics and physics associated with the rapid expansion of the detonation product fireball following an explosion, it is imperative to have a full description of its associated velocity field. Typical experimental techniques rely on simple single-point measurements captured from pressure transducers or Hopkinson pressure bars. In this technical design note, we aim to improve the current state-of-the-art by introducing a means to determine full velocity fields from high-speed video using optical flow tracking velocimetry. We demonstrate the significance of this method from our results by comparing velocity fields derived from high-speed video and a validated numerical model of the same case. A wider use of this technique will allow researchers to elucidate spatial and temporal features of explosive detonations, which could not be obtained thus far using single-point measurements

A review of the relationship between eggshell colour and water vapour conductance

This review brings together the available literature that examines the effect of variations in pigmentation on the gas conductance of avian eggshells. Pheasant and Houbara bustard eggs provide some evidence that shell abnormalities can impact upon colour and conductance. By contrast, data from wild birds suggest that neither the degree of maculation or intensity of ground colour impact upon gas conductance. Those studies that purport to show variation in rates of water loss in eggs with different degrees of pigmentation may have been confounded by variation in nest humidity. This emerging field of research remains very much in its infancy

Transmission of Viruses from Restroom Use: A Quantitative Microbial Risk Assessment

Restroom use has been implicated in a number of viral outbreaks. In this study, we apply quantitative microbial risk assessment to quantify the risk of viral transmission by contaminated restroom fomites. We estimate risk from high-touch fomite surfaces (entrance/exit door, toilet seat) for three viruses of interest (SARS-CoV-2, adenovirus, norovirus) through eight exposure scenarios involving differing user behaviors, and the use of hand sanitizer following each scenario. We assessed the impacts of several sequences of fomite contacts in the restroom, reflecting the variability of human behavior, on infection risks for these viruses. Touching of the toilet seat was assumed to model adjustment of the seat (open vs. closed), a common touch point in single-user restrooms (home, small business, hospital). A Monte Carlo simulation was conducted for each exposure scenario (10,000 simulations each). Norovirus resulted in the highest probability of infection for all exposure scenarios with fomite surfaces. Post-restroom automatic-dispensing hand sanitizer use reduced the probability of infection for each virus by up to 99.75%. Handwashing within the restroom, an important risk-reduction intervention, was not found to be as effective as use of a non-touch hand sanitizer dispenser for reducing risk to near or below 1/1,000,000, a commonly used risk threshold for comparison

Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk

Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored. Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium. Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 × 10−4; OR, 1.04; 95% confidence interval (CI), 1.02–1.07] and rs77928427 (P = 1.86 × 10−4; OR, 1.04; 95% CI, 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2 ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor–binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue. Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2. Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk

Social Status and Its Relationship to Non-specific Stress at Late Iron Age Non Ban Jak, Northeast Thailand

The rise of social inequality is a key development in human history and is linked to deteriorating health. These associated health impacts are poorly understood for Iron Age (420 B.C.-A.D. 500) northeast Thailand. To clarify this issue we investigate whether social status differences influence non-specific stress at the site of Non Ban Jak (A.D. 300-800), which comprises two separate burial mounds. These mounds are thought to represent the neighborhoods of two distinct social groups at the site. Quantitative analyses were used to explore differences in grave goods among the adults of Non Ban Jak (N = 47). Long bone lengths, ages at death, and linear enamel hypoplasia (LEH) were examined to explore differences in non-specific stress on the basis of age, sex, burial mound, and mortuary phase. Results demonstrated that older adults of both sexes, males of all ages, and west mound individuals received greater grave good quantities and may therefore have been of higher social status. West mound individuals were taller and had a lower prevalence of LEH compared to those from the east mound. Although female LEH prevalence and mortality were reduced relative to males, decreasing stature over time and high neonatal mortality indicated greater female stress. Lower-status individuals may therefore have suffered increased stress relative to those of higher status. Artifactual and epigraphic evidence supports the suggestion of sex- and class-based status differences at Non Ban Jak, legitimized and perpetuated through the adoption of residential burial and new religious ideologies.This research has been funded by the Australian Research Council (DP110101997), the Royal Society of New Zealand Marsden Fund and a University of Otago Research Grant. SW was funded by a University of Otago Doctoral Scholarship, a University of Otago Department of Anatomy Departmental Award, and a University of Otago Publishing Bursary

Environmental and social change in northeast Thailand during the Iron Age

The Iron Age of Mainland Southeast Asia began in the fifth century bc and lasted for about a millennium. In coastal regions, the development of trade along the Maritime Silk Road led to the growth of port cities. In the interior, a fall in monsoon rains particularly affected the Mun River valley. This coincided with the construction of moats/reservoirs round Iron Age settlements from which water was channelled into wet rice fields, the production of iron ploughshares and sickles, population growth, burgeoning exchange and increased conflict. We explore the social impact of this agricultural revolution through applying statistical analyses to mortuary samples dating before and after the development of wet rice farming. These suggest that there was a swift formation of social elites represented by the wealth of mortuary offerings, followed by a decline. Two associated changes are identified. The first involved burying the dead in residential houses; the second considers the impact of an increasingly aquatic environment on health by examining demographic trends involving a doubling of infant mortality that concentrated on neonates. A comparison between this sequence and that seen in coastal ports suggests two interconnected instances of rapid pathways to social change responding to different social and environmental stressors

Environmental and Social Change in Northeast Thailand during the Iron Age

The Iron Age of Mainland Southeast Asia began in the fifth century bc and lasted for about a millennium. In coastal regions, the development of trade along the Maritime Silk Road led to the growth of port cities. In the interior, a fall in monsoon rains particularly affected the Mun River valley. This coincided with the construction of moats/reservoirs round Iron Age settlements from which water was channelled into wet rice fields, the production of iron ploughshares and sickles, population growth, burgeoning exchange and increased conflict. We explore the social impact of this agricultural revolution through applying statistical analyses to mortuary samples dating before and after the development of wet rice farming. These suggest that there was a swift formation of social elites represented by the wealth of mortuary offerings, followed by a decline. Two associated changes are identified. The first involved burying the dead in residential houses; the second considers the impact of an increasingly aquatic environment on health by examining demographic trends involving a doubling of infant mortality that concentrated on neonates. A comparison between this sequence and that seen in coastal ports suggests two interconnected instances of rapid pathways to social change responding to different social and environmental stressors.We wish to thank the The Fine Arts Department of Thailand and the National Research Council for their support and permission to excavate Non Ban Jak. This research was funded in 2011–14 by the Australian Research Council, in 2014 by Earthwatch and its Research Corps, in 2015 by the University of Otago and in 2016–18 by the Marsden Fund of New Zealand