Diabète de type I et de type II : de la génétique à la clinique

This paper describes a local update scheme for the algorithm of Sugiyama and Misue (IEEE Trans. on Systems, Man, and Cybernetics 21 (1991) 876--892) for drawing views of compound graphs. A view is an abstract representation of a compound graph; it is generated by contracting subgraphs into meta nodes. Starting with an initial view, the underlying compound graph is explored by repeatedly expanding or contracting meta nodes. The novelty is a totally local update scheme of the algorithm of Sugiyama and Misue. It is more e#cient than redrawing the graph entirely, because the expensive steps of the algorithm, e. g., level assignment or crossing minimization, are restricted to the modified part of the compound graph. Also, the locality of the updates preserves the user's mental map: nodes not a#ected by the expand or contract operation keep their levels and their relative order; expanded edges take the same course as the corresponding contracted edge

Deterministic local layouts through high-dimensional layout stitching

In this paper we present a layout technique for dynamic views of large static graphs. It aims to minimize changes between two consecutive frames and most importantly, it is deterministic. First, a set of small layout patches is pre-computed. Then, depending on the users view focus, a subset of these patches is selected and connected to generate the final layout. In contrast to the state-of-the-art approach that operates in the 2D screen space only, we perform this process in highdimensional space before projecting the results into the 2D plane. This gives additional degrees of freedom and consequently a smoother transition process between two consecutive frames. Whenever the user visits an area of the graph for a second time, the layout will still look the same. This enables the user to recognize areas that have already been explored and thus preserve the mental map

Concentrações de creatino quinase, aspartato aminotransferase e desidrogenase lática em potros do nascimento até os seis meses de idade Concentration of creatine kinase, aspartate aminotransferase and lactate dehydrogenase in foals from birth up to sixth month

Dez potros da raça Puro Sangue de Corrida (PSC), de ambos os sexos, foram avaliados quanto à concentração das enzimas séricas creatino quinase (CK), aspartato aminotransferase (AST) e deshidrogenase lática (DHL). Foram colhidas amostras sangüíneas diariamente do 1º ao 7ºdia de vida e depois aos 15, 30, 60, 90, 120, 150 e 180 dias de idade. A concentração da CK mostrou um decréscimo significativo (p< 0,0003) do1º ao 7º dia de idade, e variação também significativa (p< 0,0044) entre o 15º dia de vida até os seis meses. A AST apresentou elevação significativa (p< 0,0001) até os 102 dias de idade, sofrendo posterior declínio até o 6º mês. A DHL apresentou decréscimo significativo (p< 0,0002) nas suas concentrações entre os 15 e 120 dias de idade, com posterior elevação até o 6º mês. Aos seis meses de idade as concentrações séricas de CK, AST e DHL, estão próximas as de eqüinos adultos.<br>Ten Thoroughbred foals, male and female, had the seric concentration of creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) determined. Blood samples were collected every day from days 1 to 7 and on days 15, 30, 60, 90, 120, 150 and 180 of age. CK activity decreased significantly (p< 0.0003) in the first week and showed significant variation between day 15 and 6 months of age. AST showed a significant (p< 0.0001) increase in its values until 102 days of age, decreasing subsequently until 6 months of age. LDH values decreased significantly (p< 0.0002) between days 15 and 120, increasing subsequently until 6 months of age. At 6 months of age CK, AST and LDH activities were close to those of adult horses