Organization of medical care in adult population with non-production eye injuries.

Aim: justify the need for institutional arrangements for the provision of medical care to adults with non-productive eye injuries. Material and Methods: analytical, medical, statistical, and comparative analysis. Results. The problem of eye injuries is unresolved today and has not only medical, but also a great social importance. The study calls the structure revealed that the majority of the adult population is unevenly within 24 hours of the first day sought treatment. So, the peak of appeals noted in the first half of a day. Every fourth victim turned to a medical institution for the first two hours after the injury. Young people under the age of 18 years sought medical help almost half of the cases within two hours after injury (40.6%). In 7.4% of cases, the treatment of ocular injury was performed in a hospital. 99.3% of patients with eye injuries recovered. The outcome of treatment was significantly depended on the nature of the injury (p<0.0001). Disability transferred 7.7% of those with penetrating eye injury. As a result, the treatment of the pathology of the right eye has fallen by almost half, and left — one-third. Nevertheless disability transferred 7.7% of those with penetrating eye injury. Of all the injuries it was 0.2%. Conclusion: Thus, the type of treatment is not affected in the production of significantly depended on the nature of the injury on the duration of ocular trauma was significantly influenced by the age of the injured and the diagnosis (p<0.0001). All of this suggests the need for a differentiated approach to the treatment of eye injuries, taking into account gender differences and nosology

Dynamics of dental check-ups among the population

The aim of the article: to assess the dynamics of the population coverage of preventive inspections dentists. Material and methods: analytical, statistical, and direct observation. Results. Increase in the number of patients receiving artificial limbs, for example, in the North Caucasus Federal District (+21.8% from 2008 to 2009) And Far East (-30.1 % over the same period). Given that in the North Caucasus Federal District smallest number of patients received pros-theses, such a growth indicator may be due to the volume of supply in the region, taking into account the needs of the population. The sharp decline in the availability of prosthetic patients Far East against the background of dissonance between sanitized and in need of rehabilitation patients with sufficient personnel potential evidence of regional problems in dental care. Even more interesting is the distribution of the proportion of patients who received free dentures. In the North Caucasus Federal District, along with an increase in the total number of patients who received artificial limbs, sharply reduced the proportion of patients who received them free of charge (-64.9% from 2008 to 2009). In a number of countries have not produced any free prosthetics. Conclusion. Reduced the number of patients who received pros-theses, especially for free. The most unfavorable situation is observed in the North Caucasus Federal District (-64.9%), mainly due to the Chechen Republic and the Republic of Dagestan, where the figure is zero. The current situation in the field of dental care, requires a differentiated approach and to adequately address problems from a regional perspective

The analysis of security with dentists in contemporary Russia

Aim: to carry out the analysis of security with dentists in the country in new conditions of reforming. Materials and methods. In work the complex of methods of collecting and the analysis of materials of research is used: bibliographic, analytical, documentary (fragment of data from medical documentation), epidemiological, mathematical and statistical, current supervision. Results. The used integrated approach to tasks allowed to assess a situation on security with the orthopedic stomatologic help and its demand in a section of subjects of the country. The carried-out analysis showed that in general across Russia and in a number of its districts, coverage by routine inspections of the population has the resistant tendency to decrease which is especially expressed in the Volga Federal District (-15,8%). It led to reduction of number of the patients needing sanitation and received sanitation (it is maximum — in Ural federal district (-16,9%). According to official statistics the smallest number of the patients who received the orthopedic stomatologic help — inhabitants of North Caucasus federal district, maximum — Central Federal District. Conclusion. Thus, the analysis of a condition of stomatologic help in the country from 2006 to 2012 let us establish the highest attendance of experts in Volga (108,2% in 2006, 101,3% in 2012) and Central (100,3%-2006, 102,1 %-2012) federal districts, growth of attendance in North Caucasian (for 66,2%) and Far East (for 22%) federal districts. Coverage by routine inspections of the population by stomatologists had the resistant tendency to decrease which is especially expressed in the Volga Federal District (-15%). Decrease in possibility of identification of the patients needing in sanitation and number of the patients who received it was most expressed in Ural federal district: — 16,9%.</p

Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

Parkinson’s disease is a neurodegenerative movement disorder that currently has no disease-modifying treatment, partly owing to inefficiencies in drug target identification and validation. We use Mendelian randomization to investigate over 3,000 genes that encode druggable proteins and predict their efficacy as drug targets for Parkinson’s disease. We use expression and protein quantitative trait loci to mimic exposure to medications, and we examine the causal effect on Parkinson’s disease risk (in two large cohorts), age at onset and progression. We propose 23 drug-targeting mechanisms for Parkinson’s disease, including four possible drug repurposing opportunities and two drugs which may increase Parkinson’s disease risk. Of these, we put forward six drug targets with the strongest Mendelian randomization evidence. There is remarkably little overlap between our drug targets to reduce Parkinson’s disease risk versus progression, suggesting different molecular mechanisms. Drugs with genetic support are considerably more likely to succeed in clinical trials, and we provide compelling genetic evidence and an analysis pipeline to prioritise Parkinson’s disease drug development