Women entrepreneurs : jumping the corporate ship or gaining new wings.

Paper originally presented at the 30th International Conference of the Institute for Small Business and Entrepreneurship, 7-9 November 2007, Glasgow,UK. Awarded Best Paper ‘Women’s Enterprise and Family Enterprise Development’ track, ISBE Conference 2007 (£500). Advances field through empirical investigation of push-pull dichotomy in career transition literature for women leaving corporate employment for entrepreneurship. Argues women’s motivations for entrepreneurship remain unsatisfied until businesses evolved and they gained personal and professional development

Nanoparticles for Applications in Cellular Imaging

In the following review we discuss several types of nanoparticles (such as TiO2, quantum dots, and gold nanoparticles) and their impact on the ability to image biological components in fixed cells. The review also discusses factors influencing nanoparticle imaging and uptake in live cells in vitro. Due to their unique size-dependent properties nanoparticles offer numerous advantages over traditional dyes and proteins. For example, the photostability, narrow emission peak, and ability to rationally modify both the size and surface chemistry of Quantum Dots allow for simultaneous analyses of multiple targets within the same cell. On the other hand, the surface characteristics of nanometer sized TiO2allow efficient conjugation to nucleic acids which enables their retention in specific subcellular compartments. We discuss cellular uptake mechanisms for the internalization of nanoparticles and studies showing the influence of nanoparticle size and charge and the cell type targeted on nanoparticle uptake. The predominant nanoparticle uptake mechanisms include clathrin-dependent mechanisms, macropinocytosis, and phagocytosis

Assessment of chronic post-surgical pain after knee replacement : development of a core outcome set

Background Approximately 20% of patients experience chronic post-surgical pain (CPSP) after total knee replacement (TKR). There is scope to improve assessment of CPSP after TKR, and this study aimed to develop a core outcome set. Methods Eighty patients and 43 clinicians were recruited into a three-round modified Delphi study. In Round 1, participants were presented with 56 pain features identified from a systematic review, structured interviews with patients and focus groups with clinicians. Participants assigned importance ratings, using a 1–9 scale, to individual pain features; those features rated as most important were retained in subsequent rounds. Consensus that a pain feature should be included in the core outcome set was defined as the feature having a rating of 7–9 by ≥70% of both panels (patients and clinicians) and 1–3 by ≤15% of both panels or rated as 7–9 by ≥90% of one panel. Results Round 1 was completed by 71 patients and 39 clinicians, and Round 3 by 62 patients and 33 clinicians. The final consensus was that 33 pain features were important. These were grouped into an 8-item core outcome set comprising: pain intensity, pain interference with daily living, pain and physical functioning, temporal aspects of pain, pain description, emotional aspects of pain, use of pain medication, and improvement and satisfaction with pain relief. Conclusions This core outcome set serves to guide assessment of CPSP after TKR. Consistency in assessment can promote standardized reporting and facilitate comparability between studies that address a common but understudied type of CPSP

Code size minimization and retargetable assembly for custom EPIC and VLIW instruction formats

SIGLEAvailable from British Library Document Supply Centre-DSC:4335.26205(2000-141) / BLDSC - British Library Document Supply CentreGBUnited Kingdo