61 research outputs found
Assessment of serum neopterin as an inflammatory and cardiovascular marker in type 1 and 2 diabetes complicated by diabetic foot syndrome: a comparative study
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Introduction. Neopterin is a byproduct of nerve transÂmitter coenzyme that is synthesized and released by macrophages and T-lymphocytes. It is a useful inflamÂmatory marker of diabetes progression, as its levels increase with the progression of the disease from prediabetes to type 2 diabetes (T2D). This study aimed to compare serum neopterin levels between type-1 and type-2 diabetes patients with diabetic foot syndrome (DFS), and assess the relation between serum neopterin levels and cardiometabolic risk factors.
Materials and methods. This observational cross-secÂtional study was carried out in the Centre of Diabetes Mellitus in Erbil, Iraq from 1st January to 31st December 2016. A total of 30 healthy subjects and 140 patients with DFS [70 patients with type 1 diabetes (T1D) and 70 patients with T2D] were enrolled in the study. The main outcome measurements included anthropometric measurements, blood pressure, fasting serum glucose, glycated haemoglobin, lipid profile, neopterin and high sensitivity C-reactive protein (hs-CRP).
Results. Serum neopterin levels of T2D patients were significantly (p < 0.001) higher than the corresponding levels of T1D patients (18.6 ± 2.1 nmol/L vs. 12.6 ± 1.3 nmol/L). The changes in the serum neopterin levels were related to cardiometabolic risk factors. In T1D, a significant positive correlation between serum levels of neopterin and diastolic blood pressure were obÂserved, while in T2D the significant positive correlation was found between fasting serum triglyceride levels and neopterin levels. Serum levels of neopterin were insignificantly correlated with hs-CRP in T1D and T2D.
Conclusions. In patients with DFS, serum neopterin levÂels are significantly higher in those with T2D compared with T1D patients. Neopterin levels are not related to the grading of DFS, but are invariably related to cardioÂmetabolic risk factors. (Clin Diabetol 2018; 7, 2: 91–96
Ocena stężenia neopteryny w surowicy jako wskaźnika zapalenia i czynnika ryzyka kardiometabolicznego u chorych na cukrzycę typu 1 i typu 2 powikłaną zespołem stopy cukrzycowej — badanie porównawcze
Introduction. Neopterin is a byproduct of nerve transÂmitter coenzyme that is synthesized and released by macrophages and T-lymphocytes. It is a useful inflamÂmatory marker of diabetes progression, as its levels increase with the progression of the disease from prediabetes to type 2 diabetes (T2D). This study aimed to compare serum neopterin levels between type-1 and type-2 diabetes patients with diabetic foot syndrome (DFS), and assess the relation between serum neopterin levels and cardiometabolic risk factors. Materials and methods. This observational cross-secÂtional study was carried out in the Centre of Diabetes Mellitus in Erbil, Iraq from 1st January to 31st December 2015. A total of 30 healthy subjects and 140 patients with DFS [70 patients with type 1 diabetes (T1D) and 70 patients with T2D] were enrolled in the study. The main outcome measurements included anthropometric measurements, blood pressure, fasting serum glucose, glycated haemoglobin, lipid profile, neopterin and high sensitivity C-reactive protein (hs-CRP). Results. Serum neopterin levels of T2D patients were significantly (p < 0.001) higher than the correspondÂing levels of T1D patients (18.6 ± 2.1 mg/L vs. 12.6 ± 1.3 mg/L). The changes in the serum neopterin levels were related to cardiometabolic risk factors. In T1D, a significant positive correlation between serum levels of neopterin and diastolic blood pressure were obÂserved, while in T2D the significant positive correlation was found between fasting serum triglyceride levels and neopterin levels. Serum levels of neopterin were insignificantly correlated with hs-CRP in T1D and T2D. Conclusions. In patients with DFS, serum neopterin levÂels are significantly higher in those with T2D compared with T1D patients. Neopterin levels are not related to the grading of DFS, but are invariably related to carÂdiometabolic risk factors.Â
WstÄ™p. Neopteryna jest produktem ubocznym reakcji koenzymu przekaźnika nerwowego syntetyzowanym i wydzielanym przez makrofagi i limfocyty T. Jest ona użytecznym wskaźnikiem zapalnym zaawansowania cukrzycy, ponieważ jej stężenia zwiÄ™kszajÄ… siÄ™ w wraz z progresjÄ… choroby od stanu przedcukrzycowego do jawnej cukrzycy typu 2 (T2D). Badanie przeprowadzoÂno w celu porównania stężeÅ„ neopteryny w surowicy u chorych z zespoÅ‚em stopy cukrzycowej (DFS) bÄ™dÄ…cym powikÅ‚aniem cukrzycy typu 1 lub typu 2. Dodatkowo zaÂmierzano ocenić zależność miÄ™dzy stężeniami neopteryny w surowicy a czynnikami ryzyka kardiometabolicznego.
MateriaÅ‚ i metody. Badanie o charakterze obserwacyjÂnym przeprowadzono w oÅ›rodku diabetologicznym w mieÅ›cie Erbil w Iraku od 1 stycznia do 31 grudnia 2016 roku. Do badania wÅ‚Ä…czono 30 zdrowych osób oraz 140 chorych na cukrzycÄ™ z DFS — 70 z cukrzycÄ… typu 1 (T1D) i 70 z T2D. Do głównych parametrów ocenianych w badaniu należaÅ‚y: pomiary antropometryczne, ciÅ›nienie tÄ™tnicze, glikemia na czczo, hemoglobina glikowana, profil lipidowy, stężenie neopteryny i stężenie biaÅ‚ka C-reaktywnego oznaczanego metodÄ… wysokoczuÅ‚Ä… (hs-CRP).
Wyniki. Stężenie neopteryny w surowicy byÅ‚o istotnie wyższe (p < 0,001) u chorych na T2D niż u chorych na T1D (18,6 ± 2,1 nmol/l vs. 12,6 ± 1,3 nmol/l). Zmiany wartoÅ›ci stężeÅ„ neopteryny w surowicy wiÄ…zaÅ‚y siÄ™ z wystÄ™powaniem czynników ryzyka kardiometaboliczÂnego. U chorych na T1D zaobserwowano istotnÄ… dodatÂniÄ… korelacjÄ™ miÄ™dzy stężeniem neopteryny w surowicy a ciÅ›nieniem rozkurczowym, natomiast u chorych na T2D wykazano istotnÄ… dodatniÄ… korelacjÄ™ miÄ™dzy stę¿eniem neopteryny a stężeniem triglicerydów na czczo. Zarówno u chorych na T1D, jak i u osób z T2D stężenie neopteryny w surowicy wiÄ…zaÅ‚o siÄ™ z hs-CRP.
Wnioski. U grupie chorych z DFS stężenie neopteryny w surowicy byÅ‚o istotnie wyższe u osób z T2D niż u pacjentów z T1D. Nie stwierdzono zależnoÅ›ci miÄ™dzy stężeniem neopteryny a stopniem ciężkoÅ›ci DFS, wykazano natomiast zwiÄ…zek z czynnikami kardiomeÂtabolicznymi
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Population Structure of Pythium irregulare, P. ultimum, and P. sylvaticum in Forest Nursery Soils of Oregon and Washington
Pythium species are important soilborne pathogens occurring in the forest nursery industry of the Pacific Northwest. However, little is known about their genetic diversity or population structure and it is suspected that isolates are moved among forest nurseries on seedling stock and shared field equipment. In order to address these concerns, a total of 115 isolates of three Pythium species (P. irregulare, P. sylvaticum, and P. ultimum) were examined at three forest nurseries using simple sequence repeat (SSR) and amplified fragment length polymorphism (AFLP) markers. Analyses revealed distinct patterns of intraspecific variation for the three species. P. sylvaticum exhibited the most diversity, followed by P. irregulare, while substantial clonality was found in P. ultimum. For both P. irregulare and P. sylvaticum, but not P. ultimum, there was evidence for significant variation among nurseries. However, all three species also exhibited at least two distinct lineages not associated with the nursery of origin. Finally, evidence was found that certain lineages and clonal genotypes, including fungicide-resistant isolates, are shared among nurseries, indicating that pathogen movement has occurred
TPH2 Gene Polymorphisms and Major Depression – A Meta-Analysis
BACKGROUND: Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in the synthetic pathway for brain serotonin and is considered key factor for maintaining normal serotonin transmission in the central neuron system (CNS). Gene-disease association studies have reported a relationship between TPH2 and major depressive disorder (MDD) in different populations, however subsequent studies have produced contradictory results. OBJECTIVES: We performed a systematic overview and a meta-analysis with all available data up-to-date. METHODS: We scrutinized PubMed, Embase, HuGNet and China National Knowledge Infrastructure (CNKI ) and last update was held on October 2011. We also searched the manuscripts and the supplementary documents of the published genome-wide association studies in the field. Effect sizes of independent loci that have been studied in more than 3 articles were synthesized using fixed and random effects models. RESULTS: We found 27 eligible articles that studied a total of 74 single nucleotide polymorphisms (SNPs). Finally, 12 independent loci were included in the meta-analysis. The synthesis of the data shown that two SNPs (rs4570625 and rs17110747) were associated with MDD using fixed effects models. SNP rs4570625 had low heterogeneity and remained significant using the more conservative random effects calculations with a summary OR = 0.83 (95% CI: 0.73-0.96). CONCLUSION: The current study identified a SNP (rs4570625) with strong epidemiological credibility; however more studies are required to provide robust evidence for other weak associations
Individualism and stock price crash risk
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WeilandPopulationStructurePythium.pdf
Pythium species are important soilborne pathogens occurring in the forest nursery industry of the Pacific Northwest. However, little is known about their genetic diversity or population structure and it is suspected that isolates are moved among forest nurseries on seedling stock and shared field equipment. In order to address these concerns, a total of 115 isolates of three Pythium species (P. irregulare, P. sylvaticum, and P. ultimum) were examined at three forest nurseries using simple sequence repeat (SSR) and amplified fragment length polymorphism (AFLP) markers. Analyses revealed distinct patterns of intraspecific variation for the three species. P. sylvaticum exhibited the most diversity, followed by P. irregulare, while substantial clonality was found in P. ultimum. For both P. irregulare and P. sylvaticum, but not P. ultimum, there was evidence for significant variation among nurseries. However, all three species also exhibited at least two distinct lineages not associated with the nursery of origin. Finally, evidence was found that certain lineages and clonal genotypes, including fungicide-resistant isolates, are shared among nurseries, indicating that pathogen movement has occurred
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