Reaction of APUD-System Cells of Experimental Biomodels to Subcutaneous Immunization by <i>Yersinia pestis</i> EV Vaccine Strain

It was stated that the reaction of APUD-system cells reflects immunologic and adaptive-compensatory processes in the organisms of guinea-pigs subcutaneously inoculated by Y. pestis EV vaccine strain. Shown was the dynamics of changing of activity and quantity of apudocytes in immunocompetent organs in different periods of immunogenesis after anti-plague vaccination of biomodels. Implementation of quantitative assessment of content and function of apudocytes in lymphoid organs and adrenals during vaccination process allows characterizing the adaptive-compensatory reactions in biomodel organism and makes it possible to comparatively analyze reactogenicity and safety of vaccines developed against this infection on the stages of their preclinical trials

Characteristic of Сells' Reaction of APUD-System of Guinea Pigs as Marker of Adaptive-Compensatory Processes under Aerogenic Immunization against Plague

Carried out was morphometric analysis of cells' reaction of APUD system (neuroendocrinal cells) of guinea pigs immunized with live plague vaccine by aerogenic method. The results of investigations were compared with characteristics of the state of biomodel's internal organs. Elucidated was that the changes of morphofunctional state of neuroendocrinal cells in lungs and organs of immunity were of phase character suggesting the involvement of APUD system elements in the inhalant method of antigenic material intake. Assessment of APUD-system cell's reaction enables to estimate indirectly the nature of adaptive and compensatory processes in biomodel in the course of anti-plague vaccination