Fermi surfaces and anomalous transport in quasicrystals

Fermi surfaces of several quasicrystalline approximants are calculated by means of ab-initio methods which enable direct comparison with dHvA experiments. A criterion for anomalous metallic transport is proposed and power-law temperature dependence of electronic conductivity is deduced from scaling analysis of the Kubo formula.Comment: 8 pages, 7 figures. to appear in Phys. Rev.

Charmless Final State Interaction in B-> pi pi decays

We estimate effects of the final state interactions in B -> pi pi decays coming from rescattering of pi pi via exchange of rho, sigma, f_0 mesons. Then we include the rho rho rescattering via exchange of pi, omega, a_1 mesons and finally we consider contributions of the a_1 pi rescattering via exchange of rho. The absorptive parts of amplitudes for these processes are determined. In the case of pi^+ pi^- decay mode, due to model uncertainties, the calculated contribution is |M_A| =< 1.7 x 10^-8 GeV. This produces a small relative strong phase for the tree and color-suppressed B -> pi pi amplitudes consistent with the result of a recent phenomenological analysis based on the BaBar and Belle results for the B -> pi pi branching ratios and CP asymmetries.Comment: 10 pages, 2 figure

A Phase-Space Approach to Collisionless Stellar Systems Using a Particle Method

A particle method for reproducing the phase space of collisionless stellar systems is described. The key idea originates in Liouville's theorem which states that the distribution function (DF) at time t can be derived from tracing necessary orbits back to t=0. To make this procedure feasible, a self-consistent field (SCF) method for solving Poisson's equation is adopted to compute the orbits of arbitrary stars. As an example, for the violent relaxation of a uniform-density sphere, the phase-space evolution which the current method generates is compared to that obtained with a phase-space method for integrating the collisionless Boltzmann equation, on the assumption of spherical symmetry. Then, excellent agreement is found between the two methods if an optimal basis set for the SCF technique is chosen. Since this reproduction method requires only the functional form of initial DFs but needs no assumptions about symmetry of the system, the success in reproducing the phase-space evolution implies that there would be no need of directly solving the collisionless Boltzmann equation in order to access phase space even for systems without any special symmetries. The effects of basis sets used in SCF simulations on the reproduced phase space are also discussed.Comment: 16 pages w/4 embedded PS figures. Uses aaspp4.sty (AASLaTeX v4.0). To be published in ApJ, Oct. 1, 1997. This preprint is also available at http://www.sue.shiga-u.ac.jp/WWW/prof/hozumi/papers.htm

Adenoviral p53 gene therapy for lung cancer

To determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit