A CASE OF SUCCESSFUL TREATMENT OF SYNCHRONOUS MULTIPLE PRIMARY CANCER OF THE OESOPHAGUS AND LEFT KIDNEY

The  article  describes   a  clinical  case  of  successful treatment  of  the   patient  with synchronous multiple  primary  esophageal cancer  and  cancer  of  the  left  kidney.  Singlestage extended 3-field lymph node Lewis operation and left nephrectomy were performed in  Thoracic  and  Abdominal  Surgery  Department of  the  Volgograd   Regional  oncologic dispensary clinic. The article stresses the  possibility of a single-stage combined surgery  of the esophagus and kidney

СЛУЧАЙ УСПЕШНОГО ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ ПЕРВИЧНО-МНОЖЕСТВЕННОГО СИНХРОННОГО РАКА ПИЩЕВОДА И ЛЕВОЙ ПОЧКИ

The  article  describes   a  clinical  case  of  successful treatment  of  the   patient  with synchronous multiple  primary  esophageal cancer  and  cancer  of  the  left  kidney.  Singlestage extended 3-field lymph node Lewis operation and left nephrectomy were performed in  Thoracic  and  Abdominal  Surgery  Department of  the  Volgograd   Regional  oncologic dispensary clinic. The article stresses the  possibility of a single-stage combined surgery  of the esophagus and kidney.В статье  описывается клинический случай  успешного  хирургического лечения больного первично-множественным синхронным раком  пищевода и левой  почки. В условиях  торакоабдоминального отделения ГУЗ ВОКОД №1 выполнено одномоментное оперативное вмешательство в объеме расширенной 3F операции Льюиса  и нефрэктомии слева. Показана возможность одномоментного сочетанного оперативного вмешательства на пищеводе и почке

SURGICAL PALLIATIVE AND SYMPTOMATIC TREATMENT OF REGIONAL CANCER OF THE CARDIOESOPHAGEAL JUNCTION

The article deals with the issues regarding the optimization of surgical treatment strategies in regional and metastatic cancer of the cardioesophageal junction which result in elimination of gastric fistulas. Shortand long-term effects of 238 surgeries between 1990 and 2010 have been studied. The benefits of surgical and endoscopic esophageal stenting over gastrostomy have been reported. The indication for and esophageal stent placement procedures have been defined. The article concludes that cytoreductive transpleural resection surgeries were not associated with increased post-operative mortality. However,  they resulted in prolongation of patient`s lives and creating proper conditions for delivering adjuvant chemotherapy

ХИРУРГИЧЕСКОЕ ПАЛЛИАТИВНОЕ И СИМПТОМАТИЧЕСКОЕ ЛЕЧЕНИЕ РАСПРОСТРАНЕННЫХ ОПУХОЛЕЙ КАРДИОЭЗОФАГЕАЛЬНОГО ПЕРЕХОДА

The article deals with the issues regarding the optimization of surgical treatment strategies in regional and metastatic cancer of the cardioesophageal junction which result in elimination of gastric fistulas. Shortand long-term effects of 238 surgeries between 1990 and 2010 have been studied. The benefits of surgical and endoscopic esophageal stenting over gastrostomy have been reported. The indication for and esophageal stent placement procedures have been defined. The article concludes that cytoreductive transpleural resection surgeries were not associated with increased post-operative mortality. However,  they resulted in prolongation of patient`s lives and creating proper conditions for delivering adjuvant chemotherapy.В статье рассмотрены вопросы  оптимизации хирургического лечения  местнораспространенного и метастатического рака кардиоэзофагеального перехода, избавляющего больных  от носительства гастростом.  Изучены непосредственные и отдаленные исходы 238 операций, выполненных в период с 1990 по 2010 годы. Отмечены преимущества  оперативных и эндоскопических вариантов пищеводного стентирования перед гастростомиями. Определены показания и условия выполнения различных вариантов  стентирования. Выполнение  циторедуктивных трансплевральных резекций не сопровождалось эскалацией послеоперационной летальности, увеличивало продолжительность жизни пациентов и создавало условия для адьювантной химиотерапии

Diversity of ESI-MS Based Phosphatidylcholine Profiles in Basidiomycetes

Phosphatidylcholines (PC) are the main membrane lipid constituents comprising more than 50% of total glycerophospholipids. They coordinate a number of cell functions, particularly cell growth, homeostasis, secretion, recognition and communication. In basidial fungi PC are synthesized via the Kennedy pathway as well as through methylation of phosphatidylethanolamines (PE) and then undergo remodeling in Lands cycle that replaces fatty acids in PC molecules. The molecular profile of PC is determined by the genetic features that are characteristic for every species and depend on the environment. Here we present the results of ESI-MS based analyses of PC profiles of 38 species of basidiomycetes belonging to Agaricales (12), Polyporales (17), Russulales (5), Gleophyllales (2), Cantharellales (1), Auriculariales (1), Phallales (1). Although the variety of PC molecular species of basidiomycetes is rather diverse (20–38 molecular species in every profile), only 1–3 main molecular species represent 70–90% of total PC content. The most abundant of them are C36:4 and C36:3, followed by C34:1, C34:2, C36:5, C36:2. In the majority of basidiomycetes, C36:4 reaches up to 50–70% of total PC molecular species. Based on the results of hierarchical cluster analysis four main types of PC profiles which characterized the studied fungi independently from their taxonomic position, ecology, trophic status, and hyphal differentiation have been revealed. Comparative analyses of studied fungi using PCA method have shown that species of Polyporales differ from those of Agaricales by higher variability of PC profiles