Circadian Variations of Ischemic Burden Among Patients with Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Introduction Le rythmes circadiens influencent différents paramètres de la physiologie et de la physiopathologie cardiovasculaire. Récemment, une relation entre la taille d'un infarctus et l'heure du jour à laquelle il se produit a été suggérée dans des modèles expérimentaux d'infarctus du myocarde. Le but de cette étude a été de déterminer si les rythmes circadiens pouvaient influencer la gravité d'un infarctus en terme de taille et de mortalité chez les patients hospitalisés pour un infarctus du myocarde avec sus-décalage du segment ST (STEMI) ayant bénéficié d'une intervention coronarienne percutanée primaire (ICPP). Méthode Chez 353 patients consécutifs admis avec un STEMI et traités par ICPP, l'heure à la survenue des symptômes, le pic de créatine kinase (reflet de la taille d'un infarctus) et le suivi à 30 jours ont été collectés. Les patients ont été répartis en 4 groupes en fonction de l'heure de survenue de leurs symptômes (00 :00 - 05h59, 06:00 - 11 59 12 00-17h59 et 18h00-23h59). Résultats Aucune différence statistiquement significative n'a été retrouvée entre les différents groupes en ce qui concerne les caractéristiques des patients ou de leur prise en charge. Après analyse multivariée, nous avons mis en évidence une différence statistiquement significative entre les pics de créatine kinase chez les patients avec survenue des symptômes entre 00 :00 et 05:59, qui étaient plus élevés que les pics de créatine kinase chez les patients avec survenue des symptômes à tout autre moment de la journée (augmentation moyenne de 38,4%, ρ <0.05). A 30 jours, la mortalité des patients avec survenue des symptômes entre 00 :00 et 05:59 était également significativement plus élevé que celle des patients avec survenue à tout autre moment de la journée (p <0.05). Conclusion Notre étude démontre une corrélation indépendante entre la taille d'un infarctus STEMI traité par ICPP et le moment de la journée où les symptômes apparaissent. Ces résultats suggèrent que ce moment devrait être un paramètre important à prendre en compte pour évaluer le pronostic des patients

Meromorphy and topology of localized solutions in the Thomas–MHD model

The one-dimensional MHD system first introduced by J.H. Thomas [Phys. Fluids 11, 1245 (1968)] as a model of the dynamo effect is thoroughly studied in the limit of large magnetic Prandtl number. The focus is on two types of localized solutions involving shocks (antishocks) and hollow (bump) waves. Numerical simulations suggest phenomenological rules concerning their generation, stability and basin of attraction. Their topology, amplitude and thickness are compared favourably with those of the meromorphic travelling waves, which are obtained exactly, and respectively those of asymptotic descriptions involving rational or degenerate elliptic functions. The meromorphy bars the existence of certain configurations, while others are explained by assuming imaginary residues. These explanations are tested using the numerical amplitude and phase of the Fourier transforms as probes of the analyticity properties. Theoretically, the proof of the partial integrability backs up the role ascribed to meromorphy. Practically, predictions are derived for MHD plasmas

Probing the role of Nd3+ ions in the weak multiferroic character of NdMn2O5 by optical spectroscopies

Raman and infrared spectroscopies are used as local probes to study the dynamics of the Nd-O bonds in the weakly multiferroic NdMn2O5 system. The temperature dependence of selected Raman excitations reveals the splitting of the Nd-O bonds in NdMn2O5. The Nd3+ ion crystal field (CF) excitations in NdMn2O5 single crystals are studied by infrared transmission as a function of temperature, in the 1800-8000 cm-1 range, and under an applied magnetic field up to 11 T. The frequencies of all 4Ij crystal-field levels of Nd3+ are determined. We find that the degeneracy of the ground-state Kramers doublet is lifted ({\Delta}0 ~7.5 cm-1) due to the Nd3+-Mn3+ interaction in the ferroelectric phase, below TC ~ 28 K. The Nd3+ magnetic moment mNd(T) and its contribution to the magnetic susceptibility and the specific heat are evaluated from {\Delta}0(T) indicating that the Nd3+ ions are involved in the magnetic and the ferroelectric ordering observed below ~ 28 K. The Zeeman splitting of the excited crystal field levels of the Nd3+ ions at low temperature is also analyzed.Comment: This paper is accepted for publication as a Regular Article in Physical Review

Discrimination of the light CP-odd scalars between in the NMSSM and in the SLHM

The presence of the light CP-odd scalar boson predicted in the next-to-minimal supersymmetric model (NMSSM) and the simplest little Higgs model (SLHM) dramatically changes the phenomenology of the Higgs sector. We suggest a practical strategy to discriminate the underlying model of the CP-odd scalar boson produced in the decay of the standard model-like Higgs boson. We define the decay rate of "the non $b$-tagged jet pair" with which we compute the ratio of decay rates into lepton and jets. They show much different behaviors between the NMSSM and the SLHM.Comment: 5 pages, 2 figures (5 figure files

Brans-Dicke gravity and the capture of stars by black holes: some asymptotic results

In the context of star capture by a black hole, a new noticeable difference between Brans-Dicke theory and general relativity gravitational radiation is pointed out. This feature stems from the non-stationarity of the black hole state, barring Hawking's theorem.Comment: 4 pages. Submitted to Classical and Quantum Gravit

Investigation of powered nacelles on a high aspect ratio NASA supercritical wing, phase 2

A modified wing with the long core separate flow nacelle and several E(3) nacelles was utilized. The effects of nacelle and pylon cant angles and nacelle longitudinal and vertical location were investigated over a Mach number range from 0.70 to 0.83. The results at the cruise condition 0.82 Mach number and 0.55 lift coefficient are presented